Effect of ferulic acid on Myocardial Ischemia/Reperfusion Injury In Male Mice.

Abstract

Myocardial ischemia–reperfusion represents a clinically relevant problem associated with thrombolysis, angioplasty and coronary bypass surgery. Injury of myocardium due to ischemia–reperfusion includes cardiac contractile dysfunction, arrhythmias as well as irreversible myocytes damage.                                                              

A total of 24 Swiss albino adult male mice were randomized into 4 equal groups. Group (1) sham group; Group (2) control group; Group (3) control vehicle (DMSO) group; Group (4) Ferulic acid treated group.

Results of this study showed that levels of myocardial IL-6, were increased (p<0.001) in the control group. Histologically, all mice  in control group showed significant cardiac injury (p<0.001). Ferulic acid   significantly counteract the increase in myocardium level of IL-6 (P < 0.001). Histological analysis revealed that ferulic acid   markedly reduced (P < 0.001) the severity of cardiac injury in the mice underwent LAD ligation procedure.

Keywords: Ischemia-reperfusion (I/R) ,systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS) ,  Ferulic acid (FA), left anterior descending (LAD), Dimethylsulfoxide (DMSO).