VIRAL HEPATOCELLULAR CARCINOMA AND THE POTENTIAL INVOLVEMENT OF MITOCHONDRIAL DNA
DOI:
https://doi.org/10.36320/ajb/v15.i1.11720Keywords:
Mito-Nuclear, mtDNA, Liver Tum, TreatmentAbstract
Mito-Nuclear organelles are cellular organelles that regulate metabolic balance and ATP production, but they also play a crucial role in other processes, such as cell death after immunological signaling. Mitochondria set a limit on metabolites in order to create a hope object among the mitochondria. itself, however, operate as signaling molecules in response to ignoble components in terms of the prison cell While the discovery of the genetic mannequin explains susceptibility and risk, it is followed by the identification of the genetic mannequin. Despite the fact that disease has been studied for decades, no clear model has emerged as a result of it. elucidate the genetic basis as a result of advancements in polygenic/complex ailment The mitochondrial coalition of conformance with the kernel by course on metabolites generated by means of mitochondrial ability provides cells with a potential regulatory regimen above in the hope of conformity. comprising a response that changes with changing metabolic circumstances Nonetheless, the preliminary data is encouraging. impregnate as a result of tribunal after bed examinations are likely to find a clearer feature into hepatic therapies. In that review, we aspire to appear in-depth at 1 Above mitochondria, there are a variety of interactions. includes hepatitis unfavorable infection or inside result with heightened consequences due Appreciation of pathogenesis or the development of medicine
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References
D. R. Riley et al., “Bacteria-Human Somatic Cell Lateral Gene Transfer Is Enriched in Cancer Samples,” PLoS Comput. Biol., 2013. DOI: https://doi.org/10.1371/journal.pcbi.1003107
Y. Wei, C. Neuveut, P. Tiollais, and M.-A. Buendia, “Molecular biology of the hepatitis B virus and role of the X gene,” Pathol. Biol., 2010. DOI: https://doi.org/10.1016/j.patbio.2010.03.005
S. Schreiner and M. Nassal, “A role for the host DNA damage response in hepatitis B virus cccDNA formation—and beyond?,” Viruses. 2017. DOI: https://doi.org/10.3390/v9050125
B. Rousseau et al., “Overexpression and role of the ATPase and putative DNA helicase RuvB-like 2 in human hepatocellular carcinoma,” Hepatology, 2007. DOI: https://doi.org/10.1002/hep.21770
C. E. Oropeza, G. Tarnow, A. Sridhar, T. Y. Taha, R. E. Shalaby, and A. McLachlan, “The Regulation of HBV Transcription and Replication,” in Advances in Experimental Medicine and Biology, 2020. DOI: https://doi.org/10.1007/978-981-13-9151-4_3
Deye, N., Vincent, F., Michel, P., Ehrmann, S., Da Silva, D., Piagnerelli, M., … Laterre, P.-F. (2016). Changes in cardiac arrest patientsâ€TM temperature management after the 2013 “TTM†trial: Results from an international survey. Annals of Intensive et al., “Child tumors in the African environment: Difficulties in management and advocacy for health screening and care,” Pediatr. Blood Cancer, 2014. DOI: https://doi.org/10.1186/s13613-015-0104-6
B. Sun and M. Karin, “Obesity, inflammation, and liver cancer,” Journal of Hepatology. 2012. DOI: https://doi.org/10.1016/j.jhep.2011.09.020
E. J. Park et al., “Dietary and Genetic Obesity Promote Liver Inflammation and Tumorigenesis by Enhancing IL-6 and TNF Expression,” Cell, 2010 DOI: https://doi.org/10.1016/j.cell.2009.12.052
A. R. Saltiel and J. M. Olefsky, “Inflammatory mechanisms linking obesity and metabolic disease,” Journal of Clinical Investigation. 2017. DOI: https://doi.org/10.1172/JCI92035
G. Ramakrishna, A. Rastogi, N. Trehanpati, B. Sen, R. Khosla, and S. K. Sarin, “From Cirrhosis to Hepatocellular Carcinoma: New Molecular Insights on Inflammation and Cellular Senescence,” Liver Cancer, 2013. DOI: https://doi.org/10.1159/000343852
F. Marra and F. Tacke, “Roles for chemokines in liver disease,” Gastroenterology. 2014. DOI: https://doi.org/10.1053/j.gastro.2014.06.043
T. O. Keku, S. Dulal, A. Deveaux, B. Jovov, and X. Han, “The gastrointestinal microbiota and colorectal cancer,” Am. J. Physiol. - Gastrointest. Liver Physiol., 2015. DOI: https://doi.org/10.1152/ajpgi.00360.2012
T. Wang et al., “Polar body genome transfer for preventing the transmission of inherited mitochondrial diseases,” Cell, 2014. DOI: https://doi.org/10.1016/j.cell.2014.04.042
A. Caicedo, P. M. Aponte, F. Cabrera, C. Hidalgo, and M. Khoury, “Artificial Mitochondria Transfer: Current
Challenges, Advances, and Future Applications,” Stem Cells International. 2017. 15. J. A. Chuah, T. Yoshizumi, Y. Kodama, and K. Numata, “Gene introduction into the mitochondria of Arabidopsis thaliana via peptide-based carriers,” Sci. Rep., 2015.
C. D. Williamson, D. S. Wong, P. Bozidis, A. Zhang, and A. M. Colberg-Poley, “Isolation of Endoplasmic Reticulum, Mitochondria, and Mitochondria-Associated Membrane and Detergent Resistant Membrane Fractions from Transfected Cells and from Human Cytomegalovirus-Infected Primary Fibroblasts,” Curr. Protoc. Cell Biol., 2015. DOI: https://doi.org/10.1002/0471143030.cb0327s68
R. Malli et al., “Sustained Ca2+ Transfer across Mitochondria Is Essential for Mitochondrial Ca2+ Buffering, Store- operated Ca2+ Entry, and Ca2+ Store Refilling,” J. Biol. Chem., 2003. DOI: https://doi.org/10.1074/jbc.M302511200
M. Czernik, D. A. Anzalone, L. Palazzese, M. Oikawa, and P. Loi, “Somatic cell nuclear transfer: Failures, successes and the challenges ahead,” Int. J. Dev. Biol., 2019. DOI: https://doi.org/10.1387/ijdb.180324mc
K. Takeda et al., “Microinjection of serum-starved mitochondria derived from somatic cells affects parthenogenetic development of bovine and murine oocytes,” Mitochondrion, 2010. DOI: https://doi.org/10.1016/j.mito.2009.12.144
S. Chan, C. Palacios-González, and M. De Jesús Medina Arellano, “Mitochondrial Replacement Techniques, Scientific Tourism, and the Global Politics of Science,” Hastings Cent. Rep., 2017. DOI: https://doi.org/10.1002/hast.763
V. Desquiret-Dumas et al., “The mitochondrial DNA content of cumulus granulosa cells is linked to embryo quality,” Hum. Reprod., 2017. DOI: https://doi.org/10.1093/humrep/dew341
P. Bozidis, C. D. Williamson, and A. M. Colberg-Poley, “Isolation of Endoplasmic Reticulum, Mitochondria, and Mitochondria-Associated Membrane Fractions from Transfected Cells and from Human Cytomegalovirus-Infected
Primary Fibroblasts,” Curr. Protoc. Cell Biol., 2007.
K. Takeda, S. Akagi, S. Takahashi, A. Onishi, H. Hanada, and C. A. Pinkert, “Mitochondrial activity in response to serum starvation in bovine (Bos taurus) cell culture,” in Cloning and Stem Cells, 2002. DOI: https://doi.org/10.1089/15362300260339502
L. A. Hyslop et al., “Towards clinical application of pronuclear transfer to prevent mitochondrial DNA disease,” Nature, 2016. DOI: https://doi.org/10.1038/nature18303
R. Zhang, K. Nakahira, X. Guo, A. M. K. Choi, and Z. Gu, “Very Short Mitochondrial DNA Fragments and Heteroplasmy in Human Plasma,” Sci. Rep., 2016. DOI: https://doi.org/10.1038/srep36097
J. C. Chang et al., “Mitochondrial transplantation regulates antitumour activity, chemoresistance and mitochondrial dynamics in breast cancer,” J. Exp. Clin. Cancer Res., 2019. DOI: https://doi.org/10.1186/s13046-019-1028-z
B. Mallavia et al., “Mitochondrial DNA stimulates TLR9-dependent neutrophil extracellular trap formation in primary graft dysfunction,” Am. J. Respir. Cell Mol. Biol., 2020. DOI: https://doi.org/10.1165/rcmb.2019-0140OC
F. Han et al., “Donor Plasma Mitochondrial DNA Is Correlated with Posttransplant Renal Allograft Function,” Transplantation, 2019 DOI: https://doi.org/10.1097/TP.0000000000002598
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