A field study dealing with biocmetrics of some clinical variables for hepatitis C patients
DOI:
https://doi.org/10.36320/ajb/v13.i2.11757Keywords:
Hepatitis C, Interleukin-28 b, BilirubinAbstract
Hepatitis C virus is one of the most dangerous and contagious diseases, as its danger lies in the absence of obvious symptoms at the beginning of the infection. Over time, some signs may appear, such as yellowing of the skin , eyes and abdominal pain, but in advanced cases, it may lead to cirrhosis of the liver and may lead to death. The current study aims to know the extent of liver damage to infection with the virus by measuring some biochemical variables such as direct, indirect and total bilirubin, and on the other hand, measuring interleukin-28b to determine the extent of the immune response, The results showed a significant increase in direct and total bilirubin, as well as a significant increase in the concentration of Interleukin-28 b.
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Mohd Suan, Mohd Azri, et al. "Risk factors for hepatitis C infection among adult patients in Kedah state, Malaysia: A case–control study." PloS one 14.10 (2019): e0224459. DOI: https://doi.org/10.1371/journal.pone.0224459
Shiferaw, Fassil, Mekitew Letebo, and Abate Bane. "Chronic viral hepatitis: policy, regulation, and strategies for its control and elimination in Ethiopia." BMC Public Health 16.1 (2016): 1-13. DOI: https://doi.org/10.1186/s12889-016-3459-1
Kodani, Maja, et al. "Rapid and sensitive approach to simultaneous detection of genomes of hepatitis A, B, C, D and E viruses." Journal of Clinical Virology 61.2 (2014): 260-264. DOI: https://doi.org/10.1016/j.jcv.2014.06.027
Sethuraman, Nandini, Sundararaj Stanleyraj Jeremiah, and Akihide Ryo. "Interpreting diagnostic tests for SARS-CoV-2." Jama 323.22 (2020): 2249-2251. DOI: https://doi.org/10.1001/jama.2020.8259
Chen, Stephen L., and Timothy R. Morgan. "The natural history of hepatitis C virus (HCV) infection." International journal of medical sciences 3.2 (2006): 47. DOI: https://doi.org/10.7150/ijms.3.47
Silasi, Michelle, et al. "Viral infections during pregnancy." American journal of reproductive immunology 73.3 (2015): 199-213. DOI: https://doi.org/10.1111/aji.12355
Younossi, Z., and L. Henry. "Systematic review: patient‐reported outcomes in chronic hepatitis C‐the impact of liver disease and new treatment regimens." Alimentary pharmacology & therapeutics 41.6 (2015): 497-520. DOI: https://doi.org/10.1111/apt.13090
Baffy, György, Elizabeth M. Brunt, and Stephen H. Caldwell. "Hepatocellular carcinoma in non-alcoholic fatty liver disease: an emerging menace." Journal of hepatology 56.6 (2012): 1384-1391. DOI: https://doi.org/10.1016/j.jhep.2011.10.027
Vinikoor, Michael J., et al. "Association between hepatitis B co‐infection and elevated liver stiffness among HIV‐infected adults in Lusaka, Zambia." Tropical Medicine & International Health 21.11 (2016): 1435-1441. DOI: https://doi.org/10.1111/tmi.12764
Chalasani, Naga, et al. "Effects of belapectin, an inhibitor of galectin-3, in patients with nonalcoholic steatohepatitis with cirrhosis and portal hypertension." Gastroenterology 158.5 (2020): 1334-1345. DOI: https://doi.org/10.1053/j.gastro.2019.11.296
Sangisetty, Suma L., and Thomas J. Miner. "Malignant ascites: a review of prognostic factors, pathophysiology and therapeutic measures." World journal of gastrointestinal surgery 4.4 (2012): 87. DOI: https://doi.org/10.4240/wjgs.v4.i4.87
Beuthien, Wilke, Hans-Ullrich Mellinghoff, and Johannes Von Kempis. "Vasculitic complications of interferon-α treatment for chronic hepatitis C virus infection: case report and review of the literature." Clinical rheumatology 24.5 (2005): 507-515. DOI: https://doi.org/10.1007/s10067-005-1093-x
Roller, Louis, and Jenny Gowan. "Disease state management: Hepatitis and hepatitis C." AJP: The Australian Journal of Pharmacy 97.1151 (2016): 66-75.
Walsh, Daniel, and Juliet Foster. "A Contagious Other? Exploring the Public’s Appraisals of Contact with ‘Mental Illness’." International Journal of Environmental Research and Public Health 17.6 (2020): 2005. DOI: https://doi.org/10.3390/ijerph17062005
Vidales-Braz, Beatris Maria, et al. "Detection of hepatitis C virus in patients with terminal renal disease undergoing dialysis in southern Brazil: prevalence, risk factors, genotypes, and viral load dynamics in hemodialysis patients." Virology journal 12.1 (2015): 1-8. DOI: https://doi.org/10.1186/s12985-015-0238-z
Li, D. K., et al. "Proton pump inhibitors are associated with accelerated development of cirrhosis, hepatic decompensation and hepatocellular carcinoma in noncirrhotic patients with chronic hepatitis C infection: results from ERCHIVES." Alimentary pharmacology & therapeutics 47.2 (2018): 246-258. DOI: https://doi.org/10.1111/apt.14391
Ansaldi, Filippo, et al. "Hepatitis C virus in the new era: perspectives in epidemiology, prevention, diagnostics and predictors of response to therapy." World journal of gastroenterology: WJG 20.29 (2014): 9633. DOI: https://doi.org/10.3748/wjg.v20.i29.9633
Al-Hakeim, Hussein Kadhem, Furqan Muein Auda, and Basim Muhammed Ali. "Lack of correlation between non-labile iron parameters, total carbonyl and malondialdehyde in major thalassemia." Journal of clinical biochemistry and nutrition (2014): 14-24.) DOI: https://doi.org/10.3164/jcbn.14-24
Al-Zurfi, S. K., Ali, B. M., Abojassim, A. A., Albanon, R. A., & Qazmooz, H. A. (2016). Determination of some heavy metals in the blood and milk of nursing mothers: a comparative study betweenwasit and najaf provinces. Rasayan J. Chem., 9(3), 405-412.
Auda, AL Furqan M., et al. "Evaluate some biochemical changes associated with chronic renal failure patients undergoing hemodialysis in al najaf al ashraf governorate." (2014).
Min Du,1 Shanshan Zhang,1 Lin Xiao,1 Yanyan Xu,1 Peiyi Liu,1 Yuhan Tang,1 Sheng Wei,2 Mingyou Xing,3 Xiaoping Miao,2,*† and Ping Yao1,*†, The Relationship between Serum Bilirubin and Elevated Fibrotic Indices among HBV Carriers: A Cross-Sectional Study of a Chinese Population. Int J Mol Sci. 2016 Dec; 17(12): 2057.) DOI: https://doi.org/10.3390/ijms17122057
Muhammad Shahid 1, Muhammad Idrees, Bilal Nasir, Arsalan J Raja, Syed M Raza, Iram Amin, Afza Rasul, Ghias U Tayyab, Correlation of biochemical markers and HCV RNA titers with fibrosis stages and grades in chronic HCV-3a patients. Eur J Gastroenterol Hepatol . 2014 Jul;26(7):788-94. DOI: https://doi.org/10.1097/MEG.0000000000000109
Ahmed Al-Qahtani, 1 , 2 , * Mashael Al-Anazi, 1 Ayman A. Abdo, 2 , 3 Faisal M. Sanai, 2 , 4 Waleed Al-Hamoudi, 2 , 3 Khalid A. Alswat, 2 , 3 Hamad I. Al-Ashgar, 5 Mohammed Q. Khan, 5 Ali Albenmousa, 6 Nisreen Khalaf, 1 Nisha Viswan, 1 and Mohammed N. Al-Ahdal 1 , Correlation between Genetic Variations and Serum Level of Interleukin 28B with Virus Genotypes and Disease Progression in Chronic Hepatitis C Virus Infection, J Immunol Res. 2015; 2015: 768470.)
Iadonato SP, Katze MG. Genomics: hepatitis C virus gets personal. Nature 2009; 461: 357-358), interferon inhibits hepatitis B and C virus replication. J Virol 2005; 79: 3851-3854. DOI: https://doi.org/10.1038/461357a
Suppiah V, Moldovan M, Ahlenstiel G, Berg T, Weltman M, Abate ML, et al. IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. Nat Genet 2009; 41: 1100-1104. DOI: https://doi.org/10.1038/ng.447
Wagner, Karl-Heinz, et al. "Looking to the horizon: the role of bilirubin in the development and prevention of age-related chronic diseases." Clinical science 129.1 (2015): 1-25.) DOI: https://doi.org/10.1042/CS20140566
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