Breast Cancer Survival Rate; Clinico-Pathological Correlation in Duhok
DOI:
https://doi.org/10.36320/ajb/v11.i3.11862Keywords:
Breast Cancer, Survival, Age, Tumor SizeAbstract
Background: Breast cancer (BC) is a common cause of cancer related death, yet the efforts to follow-up patients in developing countries are humble. This study aims to establish a primary percentage of the 7-year BC survivors in Duhok province and correlate it to the age and the main histopathological features at time of diagnosis; including the tumor size and the status of the lymph nodes (LNs).
Material and method: A total of sixty BC patients were included in this follow-up study, all of them were diagnosed in the histopathological department of the central lab in Duhok before 2013. The survival rate was estimated by contacting the survived patients or the families of the late BC patients.
Results: The study reported 7-year survival rate of 30%. Mortality was significantly higher in patients younger than 40 years and in patients equal or older than 50 years. Most of the patients (86.7%) had tumor size equal or greater than 2cm at time of diagnosis. Mortality was significantly higher when the tumor size was greater than 5 cm. About 78.3% of the patients had positive LNs. Mortality in these patients was only slightly higher (70.2%) than those presented with negative LNs (69.2%). Conclusion: The high percentage of mortality in the first 7-years and the high percentages of patients presented with large tumor size and positive LNs at time of first diagnosis require a special attention and further follow-up studies.
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References
Stewart BW, Wild CP. World Cancer Report 2014. Geneva, Switzerland: WHO Press; 2014.
Bansal C, Pujani M, Sharma KL, Srivastava AN, Singh US. Grading systems in the cytological diagnosis of breast cancer: a review. J Cancer Res Ther. 2014; 10:839–45.
Siegel RL, Miller KD, Jemal A. Cancer Statistics. CA Cancer J Clin. 2017; 67:7–30.
Liu P, Li X, Mittendorf EA Li J, Du XL et al. Comparison of clinicopathologic features and survival in young American women aged 18-39 years in different ethnic groups with breast cancer. Br J Cancer. 2013; 109(5):1302–9.
Biffl WL, Myers A, Franciose RJ Gonzalez RJ, Darnell D. Is breast cancer in young Latinas a different disease. The American Journal of Surgery. 2001; 182:596–600.
Allemani C, Weir HK, Carreira H, Gonzalez RJ, Darnell D. Global surveillance of cancer survival 1995–2009: analysis of individual data for 25,676,887 patients from 279 population-based registries in 67 countries (CONCORD-2) Lancet. 2015; 385:977–1010.
Chen L, Linden HM, Anderson BO, Li CI. Harewood R, Spika D et al. Trends in 5-year survival rates among breast cancer patients by hormone receptor status and stage. Breast Cancer Res Treat. 2014; 147(3): 609–16.
Goldhirsch A, Glick JH, Gelber RD, Coates AS, Thürlimann B et al. Panel members. Meeting highlights: international expert consensus on the primary therapy of early breast cancer. Ann Oncol. 2005; 16:1569–83.
Zheng YZ, Wang L, Hu X, Shao ZM et al. Effect of tumor size on breast cancer-specific survival stratified by joint hormone receptor status in a SEER population-based study. Oncotarget.2015; 6:22985–95
Cowppli-Bony A, Colonna M, Ligier K, Jooste V, Defossez G et al. Descriptive epidemiology of cancer in metropolitan France: incidence, survival and prevalence. Bull Cancer. 2019; 106:617–34.
Howlader N, Noone AM, Krapcho M et al. SEER Cancer Statistics Review, 1975–2011. 2014 http://seer.cancer.gov/csr/1975_2010/. Accessed 14 August 2014.
DeSantis CE, Bray F, Ferlay J, Lortet-Tieulent J, Anderson BO et al. International Variation in Female Breast Cancer Incidence and Mortality Rates. Cancer Epidemiol Biomarkers Prev. 2015; 24:1495–1506.
Brown CR, Hambleton IR, Hercules SM, Alvarado M , Unwin N et al. Social determinants of breast cancer in the Caribbean: a systematic review. Int J Equity Health. 2017; 16:60
DeSantis CE, Fedewa SA, Goding Sauer A, Kramer JL, Smith RA et al. Breast cancer statistics, 2015: convergence of incidence rates between black and white women. CA Cancer J Clin. 2016; 66: 31‐ 42.
Yalda MI. Estrogen and Progesterone Receptors (ER and PR) Status of Breast Cancer Cases in Kurdistan and Their Correlation with Pathologic Prognostic Variables. Medical Journal of Babylon-e: 2013; 10(1): 75-84.
Farouk O, Ebrahim MA, Senbel A, Emarah Z, Abozeed W et al. Breast cancer characteristics in very young Egyptian women ≤35 years. Breast Cancer. 2016; 8:53–8.
Johansson A, Trewin CB, Hjerkind KV, Ellingjord‐Dale M, Johannesen TB et al. Breast cancer‐specific survival by clinical subtype after 7 years follow‐up of young and elderly women in a nationwide cohort. Int J Cancer. 2019;144:1251‐61.
Chen HL, Zhou MQ, Tian W, Meng KX, He HF. Effect of age on breast cancer patient prognoses: a population‐based study using the SEER 18 database. PLoS One. 2016; 11: e0165409.
Vaz-Luis I, Ottesen RA, Hughes ME Mamet R, Burstein J et al. Outcomes by tumor subtype and treatment pattern in women with small, node-negative breast cancer: A multi-institutional study. J Clin Oncol. 2014; 32:2142-50,
Dobi A, Kelemen G, Kaizer L, Weiczner R, Thurzo L et al. Breast cancer under 40 years of age: increasing number and worse prognosis. Pathology oncology research: POR. 2011; 17(2):425–8.
Schonberg MA, Marcantonio ER, Li D, Li D, Silliman RA, Ngo L et al. Breast cancer among the oldest old: tumor characteristics, treatment choices, and survival. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2010; 28(12): 2038–45.
Yancik R, Wesley MN, Ries LA, Havlik RJ, Edwards BK et al. Effect of age and comorbidity in postmenopausal breast cancer patients aged 55 years and older. Jama. 2001; 285(7):885–92.
Foulkes W. Size surprise? Tumour size, nodal status, and outcome after breast cancer. Current Oncology. 2012; 19(5):241–3.
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Copyright (c) 2019 Zihel Hassan Hussein, Mayada Ilias Yalda, Djwar Ali Haji, Tamara Qais Faraj
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