STUDY OF HISTOLOGICAL EFFECTS OF LIVER, KIDNEY AND STRUCTURAL ABNORMALITIES OF PREGNANT RAT FETUSES TREATED WITH LERCANIDIPINE
DOI:
https://doi.org/10.36320/ajb/v15.i1.12920Keywords:
liver, kidney, pregnant rat, lercanidipineAbstract
The current study aimed to demonstrate the effect of lercanidipine on the livers, kidneys, and skeletal deformities of pregnant rat fetuses during the two stages of pregnancy (16 and 20) days, respectively, this study was carried out in the animal house of the College of Science at the University of Kufa, starting from 1/10/2022 to 1/3/2023. In the current experiment, 45 female and male albino rats were used, it was distributed to 30 adult females and 15 fertile male rats for the purpose of mating only, and after mating the rats and the occurrence of pregnancy and obtaining a sufficient number of pregnant rats by (30) pregnant rats, which were divided into 3 main groups, each of which contained 10 pregnant rats, the first group represented a control group and was dosed with physiological solution only, while the second group was dosed with lercanidipine at a concentration of 10 mg / kg of body weight, while the third group was dosed with lercanidipine at a concentration of 20 mg / kg of body weight, females were dosed orally from the first day of pregnancy in one dose per day. After the end of the experiment, five pregnant rats from each group were neutered during the gestation period (16) days, while the other five were neutered during (20) days of gestation, the results of the current study showed that the treatment of pregnant females with the drug lercanidipine during pregnancy caused pathological changes in the structure of the livers of the fetuses, such as (destruction of the wall of the central vein, necrosis and degeneration of liver cells, necrosis of the hepatic tissue, and infiltration of inflammatory cells), as well as in the histological structure of fetal kidneys, which were represented by (Shrinkage of the renal glomerulus, widening of the Bowman's space, necrosis of the cells of the inner lining of the renal tubule, hemorrhage in the urinary tubules), during the gestation period of 16 days, these pathological effects increased in the tissues of these organs with an increase in the gestation period (20) days and for both livers and kidneys, compared with the control groups and for the two gestation periods (16 and 20) days, respectively,
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Copyright (c) 2023 Siham Hadi Ali AL-Shimari1 , Dalal Abdel-Hussein Kadhim AL– Essawi
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