Genetic Relationship Between Chronic Otitis Media Infection And TLR4 Gene In AL-Qadisyah province, Iraq .
DOI:
https://doi.org/10.36320/ajb/v15.i3.13645Keywords:
Toll-like receptors (TLRs), tumor necrosis factor alpha (TNFα), lipopolysaccharide (LPS)Abstract
Background :otitis media is considered the more diseases common spread related hearing loss ,This study is designed to focus on TLR4 expression that stimulating result presence LPS in otitis media
Objective :detect the genotype more infection in otitis media on blood patients sample expression in PCR Technical.
Methods :The current study blood specimens we get of 50 patient and chronic Otitis media and 50 blood samples from healthy people to Extracting and dissection of the DNA blood gram negative bacteria and evaluate the mechanical and work of LPS and its effect on Toll like receptor4.
Results :The results show most patients with P. arogenosia isolates have GG genotype 9 in comparison with other genotype AG, 15 and AA 26 and control group show GG genotype 4 in comparison with other genotype AG 11, and AA 36 .
Conclusions: The study is showed a high rate of chronic otitis media in patients with the GG genotype, suggesting that this genotype may be a risk factor compared to the control group. On the other hand, the AA genotype was found to be ӏow in patients but high in the control group, indicating a possible is protected factor.
Downloads
References
Szymanski A, Geiger Z. (2020) Anatomy, Head and Neck, Ear. (2020) Stat Pearls
Angelo Immordino . Note on Anatomy and Physiology of the Ear .02-May-2022Department of Biomedicine, University of Palermo, Italy ARTICLE HISTORY Received - PreQC No. JCMEDU-22-62997
Hussain S . Ear anatomy and physiology. In: Logan Turner’s Diseases of the Nose, Throat and Ear. (2016) CRC Press DOI: https://doi.org/10.1201/b19780
Maria Leonor Illa ,Marco Paulo Lages Parente, Carla Bibiana Monteiro França Santos, Maria Fernanda Gentil. Biomechanical analysis of the influence of a cholesteatoma in human hearing, ( 2020) c; June( 28) Integrated Master in Bio engeneering.
Public Health England (2019) NHS Screening Programmes in England. 1 April 2017 to 31 March 2018. London: PHE
Norhayati, M. N., Ho, J. J., and Azman, M. Y. . Influenza vaccines for preventing acute otitis media in infants and children Cochrane Database Syst (2017). ;10:CD010089. doi: 10.1002/14651858.CD010089.pub3 DOI: https://doi.org/10.1002/14651858.CD010089.pub3
Ana Jotic a,b, Snezana Jesic a,b , Maja Zivkovic d , Nada Tomanovic c , Jovana Kuveljic d, Aleksandra Stankovic d . Polymorphisms in Toll-like receptors 2 and 4 genes and their Expression in chronic suppurative otitis media .Medical Faculty Belgrade, University of Belgrade, Serbia D Laboratory for Radiobiology and Molecular Genetics, Vinca Institute of Nuclear Sciences, University of Belgrade, Belgrade, Serbia (2014) DOI: https://doi.org/10.1016/j.anl.2015.04.010
Hirai, H.; Kariya, S.; Okano, M.; . Fukushima, K.; Kataoka, Y.; Maeda, Y.; Nishizaki, K. Expression of toll-like receptors in chronic Otitis media and cholesteatoma. Int. J. Pediatr. Otorhinolaryngol,(2013); 77, 674–676. DOI: https://doi.org/10.1016/j.ijporl.2013.01.010
Joosten LAB, Abdollahi-Roodsaz S, Dinarello CA, et al .Toll-like receptors and chronic inflammation in rheumat ic diseases .New developments. Nature Rev Rheumatol .( 2016 );12(6): 357–344. DOI: https://doi.org/10.1038/nrrheum.2016.61
Li P, Chen D and Huang Y, Fisetin . administration improves LPS-induced acute otitis media in mouse in vivo. Intl J Molecu Med.( 2018); 42(1): 237–247 DOI: https://doi.org/10.3892/ijmm.2018.3585
Wang P, Han X, Mo B, et al. LPS . enhances TLR4 expression and IFN c production via the /TLR4/IRAK NF jB signaling pathway in rat pulmonary arterial smooth muscle cells. Molecular Med Rep : (2017); 16(3) :3116–3111. DOI: https://doi.org/10.3892/mmr.2017.6983
Fraikin . N ,Goormaghtigh . F , Van Melderen .L ,Type II Toxin-Antitoxin Systems . Evolution and Revolutions. J. Bacteriology. (2020); 202: e00763-19. DOI: https://doi.org/10.1128/JB.00763-19
Gabarin RS, Li M, Zimmel PA, Marshall JC, Li Y, Zhang H. Intracellular and Extracellular Lipopolysaccharide Signaling in Sepsis: Avenues for Novel Therapeutic Strategies. J Innate Immun. (2021);13(6):323-332. DOI: https://doi.org/10.1159/000515740
Trzpis K , Kasprzycka E ,Skotnicka B, Hassmann-Pozna ´nska E ,Wysocka J. Expression of Toll-like receptors on peripheral Blood white cells In acute otitis media. Otolaryngology. Pol. (2014); 68 : 77–82. DOI: https://doi.org/10.1016/j.otpol.2013.06.006
Lena Hafrén, Elisabet Einarsdottir, Erna Kentala, et al. Predisposition to Childhood Otitis Media and Genetic Polymorphisms within the Toll-Like Receptor 4 (TLR4) Locus ,Petri S. Mattila (2015). DOI: https://doi.org/10.1371/journal.pone.0132551
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Baneen Hissab , Najlaa Abdallah D. Al-Oqaili
This work is licensed under a Creative Commons Attribution 4.0 International License.
which allows users to copy, create extracts, abstracts, and new works from the Article, alter and revise the Article, and make commercial use of the Article (including reuse and/or resale of the Article by commercial entities), provided the user gives appropriate credit (with a link to the formal publication through the relevant DOI), provides a link to the license, indicates if changes were made and the licensor is not represented as endorsing the use made of the work.
