Evaluation of human transforming growth factor -β and some biochemical markers in leukemia patients in Kirkuk city
DOI:
https://doi.org/10.36320/ajb/v16.i1.14153Keywords:
TGF-β, AMLAbstract
Acute myeloid leukemia is characterized by the infiltration of the bone marrow, blood, and other organs by proliferative, clonal, undifferentiated, and sometimes poorly differentiated cells that originate from the hematopoietic system. The primary objective of this study was to assess the levels of human transforming growth factor-β and several biochemical markers in individuals diagnosed with leukemia, and to determine their significance in the context of these cases. A cross-sectional study was conducted at the Kirkuk oncology center, which is situated within the Kirkuk Teaching Hospital. The investigation was carried out over the period spanning from January 2023 to May 2023. The research consisted of a total of 90 participants, with 60 individuals as patients' group and 30 healthy individuals as control group. The research encompassed individuals ranging in age from 18 to 70 years. The present finding has shown a statistically significant positive correlation (p-value 0.0086) between the presence of human transforming growth factor-β (TGF-β) in individuals with leukemia and those in the control group. Furthermore, a significant association was seen between the levels of serum creatinine in the patients and the control group. Also, the current study exists a statistically significant association between white blood cell (WBC) count, hemoglobin concentration, and platelet count (PLTs) in patients diagnosed with leukemia and individuals in a healthy control group.
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