The Evaluation Of The Serum Level Of Vimentin In Chronic Kidney Disease Patients In AL-Najaf Province/Iraq

Evaluation Of The Serum Level Of Vimentin In Chronic Kidney Disease Patients In AL-Najaf Province/Iraq

Authors

  • Rusul Shaker Al-Furat Al-Awsat Technical University
  • Mohammed Abdulrazzaq Assi

DOI:

https://doi.org/10.36320/ajb/v16.i2.15572

Keywords:

Biochemical parameters, Vimentin, chronic kidney disease

Abstract

Chronic Kidney Disease (CKD) is a complex condition characterized by kidney damage or decreased function, leading to a range of complications. These include cardiovascular risk, immune dysfunction, and lung disease. The study aims to investigate the association of E-cadherin and other biomarkers in patients suffering from CKD and the possibility of using it as diagnostic criteria for CKD. The current investigation comprised a cohort of 96 patients diagnosed with CKD and a control group of 88 healthy participants. Vimentin and other biochemical levels were estimated in the serum of patients and the control group. The results showed that patients with CKD significantly increased (p<0.05) in Vimentin serum concentrations compared to healthy participants. These findings support the evidence suggesting that this marker may play an essential role in the progression of CKD

Downloads

Download data is not yet available.

References

No Title. doi:(2023). Chronic Kidney Disease. 327-346. doi: 10.1002/9781119833475.ch20

Vergnaud P, Cohen C, Isnard P. Towards understanding chronic kidney disease. Med Sci M/S. 2023;39(3):265-270.

Brandenburg VM, Saritas T. Chronic Kidney Disease—State of Either “Too Much” or “Too Little.” Nutrients. 2023;15(7):1587.

Yao JX, Chen X, Zhu YJ, Wang H, Hu XY, Guo JM. Prognostic value of Vimentin is associated with immunosuppression in metastatic renal cell carcinoma. Front Oncol. 2020;10:1181.

Lin H, Hong Y, Huang B, Liu X, Zheng J, Qiu S. Vimentin Overexpressions induced by cell hypoxia promote Vasculogenic mimicry by renal cell carcinoma cells. Biomed Res Int. 2019;2019.

Moreno JCA, Bahmad HF, Febres-Aldana CA, et al. Post-mortem assessment of vimentin expression as a biomarker for renal tubular regeneration following acute kidney injury. J Pathol Transl Med. 2021;55(6):369.

Liebscher F, Arnold T, Liang Y, Reiter T, Böhmig G, Oehler R. Vimentin cleavage in end-stage renal disease is not related to apoptosis. Open Med. 2013;8(3):297-301.

Cassano V, Pelaia C, Armentaro G, et al. New potential biomarkers for early chronic kidney disease diagnosis in patients with different glucose tolerance status. Front Endocrinol (Lausanne). 2023;14:1206336.

Brookes EM, Power DA. Elevated serum urea-to-creatinine ratio is associated with adverse inpatient clinical outcomes in non-end stage chronic kidney disease. Sci Rep. 2022;12(1):20827.

Yanai H, Adachi H, Hakoshima M, Katsuyama H. Molecular biological and clinical understanding of the pathophysiology and treatments of hyperuricemia and its association with metabolic syndrome, cardiovascular diseases and chronic kidney disease. Int J Mol Sci. 2021;22(17):9221.

Bader RS, Kora MAAA, El-Shalakany AH, Mashal BSAAB. Clinical significance of saliva urea and creatinine levels in patients with chronic kidney disease. Menoufia Med J. 2015;28(2):406.

Mehmood HR, Khan Z, Jahangir HMS, Hussain A, Elahi A, Askari SMH. Assessment of serum biochemical derangements and associated risk factors of chronic kidney disease. J Taibah Univ Med Sci. 2022;17(3):376-383.

Ni PSC, Liu BC, Liu BC. Urinary Vimentin mRNA as a Potential Novel Biomarker of Renal Fibrosis. Published online 2015.

Lang J, Katz R, Ix JH, et al. Association of serum albumin levels with kidney function decline and incident chronic kidney disease in elders. Nephrol Dial Transplant. 2018;33(6):986-992.

Downloads

Published

2024-08-05

How to Cite

Shaker, R., & Abdulrazzaq Assi, M. (2024). The Evaluation Of The Serum Level Of Vimentin In Chronic Kidney Disease Patients In AL-Najaf Province/Iraq: Evaluation Of The Serum Level Of Vimentin In Chronic Kidney Disease Patients In AL-Najaf Province/Iraq. Al-Kufa University Journal for Biology, 16(2), 68-71. https://doi.org/10.36320/ajb/v16.i2.15572

Share