Impact Impact of IL35, IL38 on patient infected with COVID-19 on group of fertile and infertile female in Baghdad
SARS-CoV2; COVID-19; Fertility; Interleukin 35 (IL35); Interleukin 38 ( IL38)
DOI:
https://doi.org/10.36320/ajb/v16.i2.15603Keywords:
SARS-CoV2; COVID-19; Fertility; Interleukin 35 (IL35); Interleukin 38 ( IL38)Abstract
A class of RNA viruses known as coronaviruses (CoVs) infects humans and other animals. Coronaviruses which are enveloped viruses with large single-strand positive sense RNA genomes and are members of the Coronaviridae family, Studies have also documented the impact of coronaviruses on several organs and systems, such as the kidney, heart, and reproductive system. In addition, compared to men, women are more susceptible to infected with virus. The overwhelming majority of individuals with COVID-19 will have mild to moderate symptoms, however a hyper-inflammation brought on by a high production of chemokines and cytokines may occur in certain infected individuals. The anti-inflammatory cytokine interleukin-35 (IL-35) is frequently expressed on the monocyte surface, ( DCs), and macrophages. It is known that regulatory T cells are the only cells that can produce IL-35. CD8+ T cells may expressIL-35, which contributes to immunological suppression(IL38) is a crucial component of host defense and inflammation. It belongs to the interleukin-1 (IL-1) family. It is possible that IL-38 has anti-inflammatory characteristics via lowering the amount of pro-inflammatory cytokines that macrophages secrete. This study aimed to assess the effects of IL35 and IL38 on fertility in female COVID-19 infected individuals. According to our research, there is a significant relationship between COVID-19 and fertility (p =.008). This shows that each combination of fertility and COVID-19 had discernible differences in IL35 levels, however the interaction impact between fertility and COVID-19 according to IL38 level was not statistically significant (p =0.658). This implies that the IL38 levels were not significantly different for any combination of COVID-19 and fertility. In conclusion, utilizing IL 35 as immunological therapy may be essential to controlling a cytokine storm that develops in female COVID-19 infections. According to the current investigation, female fertility when infected with COVID-19 did not impact serum IL-38 levels.
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Zhong N S , Zheng B J , Li Y M , Poon L L & Xie Z H, “Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong”. People’s Republic of China.Lancet.pp.1353-1358. 2003. h ttps://doi.org/10.1016/S0140-6736(03)14630-2 .
Chen Y, & Guo D, “Molecular mechanisms of coronavirus RNA capping and methylation”. Virologica Sinica, 31, 3-11. 2016. https://doi.org/10.1007/s12250-016-3726-4
Su S, Wong G, Shi W, Liu J, & Lai AC, “Epidemiology, genetic recombination, and pathogenesis of coronaviruses”. Trends Microbiol. 24:490-502. 2016. https://doi.org/10.1016/j.tim.2016.03.003 .
Drosten C, Günther S, & Preiser W, “Identification of a novel coronavirus in patients with severe acute respiratory syndrome”. Paediatric respiratory reviews 5.4. 262-269. 2003. DOI: 10.1056/NEJMoa030747 .
Singer, R., Crooks, N., Johnson, A. K., Lutnick, A., & Matthews, A. “ COVID-19 prevention and protecting sex workers: a call to action”. Archives of Sexual Behavior, 49, 2739-2741.2020. https://doi.org/10.1007/s10508-020-01849.
Al-Sarray, A. A. M., & Shareef, R. H. “Awareness of Healthcare Providers About COVID-19 Vaccinations in Karbala City”. Journal of Techniques, 4(33), 91-96. 2022. https://doi.org/10.51173/jt.v4i33.654
Najeb H B, Mohammed A J, & Rasheed E M, “Effect of Covid-19 Vaccine on Women's Fertility Hormones”. Journal of Techniques, 4(33), 139-144. 2022. https://doi.org/10.51173/jt.v4i33.738
Wang, C., Pan, R., Wan, X., Tan, Y., Xu, L., McIntyre, R. S., & Ho, C. “A longitudinal study on the mental health of general population during the COVID-19 epidemic in China. Brain, behavior, and immunity”, 87, 40-48. 2020. https://doi.org/10.1016/j.bbi.2020.04.028
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. “Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China”. Lancet 2020. https://doi.org/10.1016/S0140-6736(20)30183-5 .
- Rabi F.A., Al Zoubi M.S., Kasasbeh G.A., Salameh D.M., Al-Nasser A.D. “SARS-CoV-2 and coronavirus disease 2019: what we know
so far”. Pathogens9:231. 2020. https://doi.org/10.3390/pathogens9030231 .
Reis, L. C., & Junior, W. F. D. S. “Variants of the ACE2 Gene: The SARV-CoV2 Receptor in Different Human Populations”. International Journal of Medical Reviews, 9(2), 268-275. 2022. DOI / 10.30491/IJMR.2021.289032.1205.
Gu J., Han B., Wang J. “COVID-19: gastrointestinal manifestations and potential fecal-oral transmission”. Gastroenterology. 2020. DOI: 10.1053/j.gastro.2020.02.054
Holshue M.L., DeBolt C., and Lindquist S. “First case of 2019 novel coronavirus in the United States”. N Engl J Med 382:929–936. 2020. DOI: 10.1056/NEJMoa2001191
Al-Lami, R A, Urban, R J, Volpi, E, Algburi, A M, & Baillargeon J, “Sex hormones and novel corona virus infectious disease (COVID-19) ”. Elsevier, Vol. 95, No. 8, pp. 1710-1714. August ,2020. https://doi.org/10.1016/j.mayocp.2020.05.013 .
Bader F et al, “Heart failure and COVID-19”. Heart Failure Reviews 26, 1–10. 2021. https://doi.org/10.1007/s10741-020-10008-2 .
Qian J “Age-dependent gender differences in COVID-19 in mainland China: comparative study”. Clinical Infectious Diseases 71, 2488–2494. 2020. https://doi.org/10.1093/cid/ciaa683 .
ussein N S, Al-Rayahi I A, Muhsin S S, & Alameer R A K, “Comparison of IgG and Neutralizing Antibody Response After Pfizer BioNTech COVID-19 Vaccine Among Iraqi Individuals”. Journal of Techniques, 5(2), 129-133. 2023. https://doi.org/10.51173/jt.v5i2.1267 .
Mehta P, McAuley D F, Brown M, Sanchez E, Tattersall R S, & Manson J J, “COVID-19: consider cytokine storm syndromes and immunosuppression”. The lancet, 395(10229), 1033-1034. 2020 . https://doi.org/10.1016/S0140-6736(20)30628-0 .
Ganji A, Farahani I, Khansarinejad B, Ghazavi A, & Mosayebi G, “Increased expression of CD8 marker on T-cells in COVID-19 patients”. Blood Cells, Molecules, and Diseases, 83, 102437. 2020. https://doi.org/10.1016/j.bcmd.2020.102437 .
Weng L, Huang G, Gong L, Xu J, Mao Y, Li Y, & Li M , “Low levels of serum IL-39 are associated with autoimmune thyroid disease”. Journal of Clinical Laboratory Analysis, 36(4), e24284. 2022. https://doi.org/10.1002/jcla.24284 .
Liu K, Huang A, Nie J, Tan J, Xing S, Qu Y, & Jiang K, “IL-35 regulates the function of immune cells in tumor microenvironment”. Frontiers in Immunology, 12, 683332. 2021. https://doi.org/10.3389/fimmu.2021.683332 .
Lin H, Ho AS, Haley-Vicente D, Zhang J, Bernal-Fussell J, Pace AM, Hansen D, Schweighofer K, Mize NK, Ford JE, “Cloning and characterization of IL-1HY2, a novel interleukin-1 family member”. J Biol Chem. 8;276(23):20597-602. Jun 2001. https://doi.org/10.1074/jbc.M010095200 .
Rudloff Ina, Godsell Jack, Nold-Petry, Claudia A, Harris James, Hoi Alberta, Morand, Eric F& Nold Marcel F, “Brief Report: Interleukin-38 Exerts Anti-inflammatory Functions and Is Associated With Disease Activity in Systemic Lupus Erythematosus”. Arthritis & Rheumatology. 67 (12): 3219–3225.2015. https://doi.org/10.1002/art.39328 .
Boutet M A, Najm A, Bart G, Brion R, Touchais S, Trichet V, et al. “IL-38 Overexpression Induces Anti-inflammatory Effects in Mice Arthritis Models and in Human Macrophages In Vitro”. Ann. Rheum. Dis. 76 (7), 1304–1312. 2017. http://dx.doi.org/10.1136/annrheumdis-2016-210630 .
Yuan X , Peng X , Li Y, & Li M, “Role of IL-38 and its Related Cytokines in Inflammation”. Mediators Inflamm , 1807976–1807977. 2015. https://doi.org/10.1155/2015/807976 .
de Graaf, D. M., Teufel, L. U., & Dinarello, C. A. “Interleukin-38 in health and disease”. 2022. DOI: 10.1016/j.cyto.2022.155824 .
Mora J, Schlemmer A, Wittig I, Richter F , Putyrski M, Frank A C, et al. “Interleukin-38 Is Released from Apoptotic Cells to Limit Inflammatory Macrophage Responses”. J. Mol. Cel Biol 8 (5), 426–438. 2016. https://doi.org/10.1093/jmcb/mjw006 .
Gao X , Chan P K S , Lui G C Y, et al. “Interleukin-38 ameliorates poly(I:C) induced lung inflammation: therapeutic implications in respiratory viral infections”. Cell Death Dis 12, 53 .2021. https://doi.org/10.1038/s41419-020-03283-2 .
Al Khikani FH, Almosawey HA, Abdullah YJ, Al Asadi AA, Hameed RM, Hasan NF, et al. , “Potential antiviral properties of antifungal drugs”. J Egypt Women’s Dermatol Soc 1 7:185.2020. DOI: 10.4103/JEWD.JEWD_40_20 .
AL Khikani FH, Ayit AS. “A scoping review of SARS CoV 2 and male infertility: Concerns and future prospects”. Asian Pac J Reprod 2022. DOI: 10.4103/2305-0500.341111 .
Ramshaw IA, Ramsay AJ, Karupiah G, Rolph M S, Mahalingam S, & Ruby J C, “Cytokines and immunity to viral infections”. Immunological reviews, 159(1), 119-135. 1997. https://doi.org/10.1111/j.1600-065X.1997.tb01011.x .
Guo Y, Cao W, Zhu Y, “ Immunoregulatory functions of the IL 12 family of cytokines in antiviral systems”. Viruses. 2019. https://doi.org/10.3390/v11090772 .
Ozkan, Z S, Deveci D , Kumbak B, Simsek M , Ilhan, F, Sekercioglu S, & Sapmaz, E, “What is the impact of Th1/Th2 ratio, SOCS3, IL17, and IL35 levels in unexplained infertility? ”. Journal of reproductive immunology, 103, 53-58. 2014. https://doi.org/10.1016/j.jri.2013.11.002 .
Mao H, Gao W, Ma C, Sun J, Liu J, Shao Q, et al., “Human placental trophoblasts express the immunosuppressive cytokine IL-35”. Hum Immunol,74:872–7.2013. https://doi.org/10.1016/j.humimm.2013.04.010 .
Ehsani , Motahareh1,Mohammadnia-Afrouzi, Mousa2,3, Mirzakhani, Mohammad1, Esmaeilzadeh, Sedighe4, Shahbazi, Mehdi2,3,. “Female Unexplained Infertility: A Disease with Imbalanced Adaptive Immunity”. Journal of Human Reproductive Sciences 12(4): p 274-282, Oct–Dec 2019. doi: 10.4103/jhrs.JHRS_30_19.
AL-Khikani, F H O , & Alkhafaji Z A ,“Interleukin-35 as a New Biomarker for SARS-CoV-2 in Iraqi Patients”. Medical Journal of Dr. DY Patil University. 2023. DOI: 10.4103/mjdrdypu.mjdrdypu_677_22.
Chen Y, Wang CJ, Lin SH, Zhang M, Li SY, Xu F, “Interleukin 35 is upregulated in response to influenza virus infection and secondary bacterial pneumonia”. Cytokine 81:23 7.2016. https://doi.org/10.1016/j.cyto.2016.01.016 .
Lorenz T K, Heiman J R, & Demas G E, “Sexual activity modulates shifts in TH1/TH2 cytokine profile across the menstrual cycle: an observational study”. Fertility and sterility, 104(6), 1513-1521. 2015. https://doi.org/10.1016/j.fertnstert.2015.09.001 .
Gao X, Wu G, Tsang M SM et al., “Novel insights into the role of anti-inflammatory IL-38 in immunity against infection”. Cell Mol Immunol 19, 1322–1324 .2022. https://doi.org/10.1038/s41423-022-00876-z .
J H Southcombe, C W G Redman, I L Sargent, I Granne, “Interleukin-1 family cytokines and their regulatory proteins in normal pregnancy and pre-eclampsia”. Clinical and Experimental Immunology, Volume 181, Issue 3, Pages 480–490. September 2015. https://doi.org/10.1111/cei.12608 .
Orsi N M, & Tribe R M, “Cytokine networks and the regulation of uterine function in pregnancy and parturition”. Journal of neuroendocrinology, 20(4), 462-469. 2008. https://doi.org/10.1111/j.1365-2826.2008.01668.x .
Al-bassam WW, Al-Karaawi IA, Sharquie IK, Ad'hiah AH. “Evaluation of interleukin-38 levels in serum of patients with coronavirus disease 2019”. J Med Virol, 94: 3642-3652. 2022. https://doi.org/10.1002/jmv.27762
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