The correlation of Interlukine 10 gene expression with hormones changes in polycystic ovary syndrome
DOI:
https://doi.org/10.36320/ajb/v16.i2.15683Keywords:
PCOS.PCOD.IL10. prolactine hormon.free testeroneAbstract
The current study was done to determine the molecular status and hormone changes in polycystic ovary syndrome and polycystic ovary disease. The study included 155 clinical specimens that included age (20-45) years, which were collected from November 2022 to June 2023. The specimens included blood specimens for patients visiting Imam Al-Sadiq Hospital and Babylon Teaching Hospital for Maternity and Children in Babylon Governorate. The results of hormones included elevation in levels of prolactin and Free Testosterone were obtained in PCOS, PCOD patients group compared with healthy women. Also, the study of some genes, including a study of genetic polymorphisms of the cellular motor gene IL10.
Downloads
References
Zhang, Y.; Ho, K.; Keaton, J. M.; Hartzel, D. N.; Day, F.; Justice, A. E.; Josyula, N. S.; Pendergrass, S. A.; Davis, L. K. and Edwards, D. R. V. (2020). A genome-wide association study of polycystic ovary syndrome identified from electronic health records. American journal of obstetrics and gynecology, 223: 559. e1-559. e21
Cincione, R. I.; Losavio, F.; Ciolli, F.; Valenzano, A.; Cibelli, G.; Messina, G. and Polito, R. (2021). Effects of Mixed of a Ketogenic Diet in Overweight and References 106.
Itriyeva, K. (2022). The normal menstrual cycle. Current Problems in Pediatric and Adolescent Health Care, 6: 101183.
Mihm, M.; Gangooly, S. And Muttukrishna, S. (2011). The normal menstrual cycle in women. Animal reproduction science, 124: 229-236.
Lewis S.M. and B.J Bain. 2001. Dacie and Lewis, Practical Haematology. 9th ed, Churchill Livigstone: 447-477.
Dehghan, E.; Namiranian, N.; Ghadiri-Anari, A.; Ratki, S. K. R. and Azizi, R. (2021). Evaluation of hyperprolactinemia risk factors in infertile women referred to Yazd Infertility Center: A cross-sectional study. International Journal of Reproductive BioMedicine, 19: 1085.
Zafar, U.; Amber Zaidi, S.; Syed Muhammad Osama Jafri, H.; Imran, S.; Bhatty, A. and Abidi, F. (2021). Effectiveness of Metformin and its Combination with Probiotic in Polycystic Ovarian Disease with Hyperprolactinemia: A Randomized Clinical Trial. Journal of Pharmaceutical Research International, 33(47A): 268 - 274.
Szosland, K.; Pawłowicz, P. and Lewiński, A. (2015). Prolactin secretion in polycystic ovary syndrome (PCOS). Neuroendocrinology Letters, 36: 53-58.
RAMIREZ, A. V. & DE SÁ, L. B. (2021). Melatonin and its relationships with diabetes and obesity: a literature review. Current Diabetes Reviews, 17: 38-50.
Chen, J.; Chen, X.; Dominiczak, A. F.; Carey, R. M.; Laffer, C. L.; Elijovich, F.; Taler, S. J.; Dudenbostel, T.; Touyz, R. M. and Wang, J.-G. (2022). A Rare Disease Leading to Hypertension. Hypertension, 79: 1147-1152.
Yang, H.; DI, J.; Pan, J.; Yu, R.; Teng, Y.; Cai, Z. and Deng, X. (2020). The association between prolactin and metabolic parameters in pcos women: A retrospective analysis. Frontiers in endocrinology, 11: 263.
Mahboobifard, F.; Rahmati, M.; Amiri, M.; Azizi, F. and Tehrani, F. R. (2022). To what extent does polycystic ovary syndrome influence the cut-off value of prolactin? Findings of a community-based study. Advances in Medical Sciences, 67: 79-86.
Ashraf, S.; Nabi, M.; Rashid, F. and Amin, S. (2019). Hyperandrogenism in polycystic ovarian syndrome and role of CYP gene variants: a review. Egyptian Journal of Medical Human Genetics, 20: 1-10.
Hendriks, M.-L.; Brouwer, J.; Hompes, P. G.; Homburg, R. and Lambalk, C. B. (2008). LH as a diagnostic criterion for polycystic ovary syndrome in patients with WHO II oligo/amenorrhoea. Reproductive biomedicine online, 16: 765-771.
Liao, B.; Qiao, J. and Pang, Y. (2021). Central regulation of PCOS: Abnormal neuronal-reproductive-metabolic circuits in PCOS pathophysiology. Frontiers in Endocrinology, 12: 667422.
Malini, N. and George, K. R. (2018). Evaluation of different ranges of LH: FSH ratios in polycystic ovarian syndrome (PCOS)–Clinical based case control study. General and comparative endocrinology, 260: 51-57.
Mohammed, Z. I. and Qasim, M. T. (2021). Correlation of AMH and LH Levels in PCOS Patients with Pregnancy Rate. Annals of the Romanian Society for Cell Biology, 7: 945-951
Mansour, A.; Sanginabadi, M.; Mohajeri-Tehrani, M. R.; Karimi, S.; Gerami, H.; Mahdavi-Gorabi, A.; Shirzad, N.; Samadi, M.; Baygi, F. and Qorbani, M.References 117(2020). Effect of Oligopin Supplementation on Polycystic Ovary Syndrome: A Randomized Controlled Trial.
Saadia, Z. (2020). Follicle stimulating hormone (LH: FSH) ratio in polycystic ovary syndrome (PCOS)-obese vs. Non-obese women. Medical Archives, 74: 289.
Dewailly, D.; Robin, G.; Peigne, M.; Decanter, C.; Pigny, P. and Catteau-Jonard, S. (2016). Interactions between androgens, FSH, anti-Müllerian hormone and estradiol during folliculogenesis in the human normal and polycystic ovary. Human reproduction update, 22: 709-724.
Mumusoglu, S. and Yildiz, B. O. (2020). Polycystic ovary syndrome phenotypes and prevalence: differential impact of diagnostic criteria and clinical versus unselected population. Current Opinion in Endocrine and Metabolic Research, 12: 66-71.
Özen, Ö. and Cander, S. (2022). Evaluation of the relationship between dehydroepiandrosterone sulfate-total testosterone ratio and metabolic parameters in patients with polycystic ovary syndrome. Turkish Journal of Internal Medicine, 4: 47-54.
Mahajan, V. K.; Chauhan, P. S.; Chandel, M.; Mehta, K. S.; Singh, V. K.; Sharma, A.; Sharma, R.; Sharma, J.; Hooda, S. and Verma, Y. R. (2021). Clinico-investigative attributes of 122 patients with hirsutism: A 5-year retrospective study from India. International Journal of Women's Dermatology, 7: 237-242.
Joham, A. E.; Piltonen, T.; Lujan, M. E.; Kiconco, S. and Tay, C. T. (2022). Challenges in diagnosis and understanding of natural history of polycystic ovary syndrome. Clinical Endocrinology, 97: 165 - 173.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Rana jaleil AL-khafagi, Basaad Abed zaid Al-Fatlawi , Abdulnabi jwaid AL-mamory
This work is licensed under a Creative Commons Attribution 4.0 International License.
which allows users to copy, create extracts, abstracts, and new works from the Article, alter and revise the Article, and make commercial use of the Article (including reuse and/or resale of the Article by commercial entities), provided the user gives appropriate credit (with a link to the formal publication through the relevant DOI), provides a link to the license, indicates if changes were made and the licensor is not represented as endorsing the use made of the work.
