Evaluation of serum level of IL-6 and TNF-α in children with autism
تقييم مستوى IL-6 وTNF-α في مصل الأطفال المصابين بالتوحد
DOI:
https://doi.org/10.36320/ajb/v17.i1.18142Keywords:
Autism, interleukins -6, tumor necrosis factors (TNF-α)Abstract
A wide range of diverse neuropsychiatric symptoms, such as difficulties with social communication, limited and specific interests, and repetitive behavior, are hallmarks of autism spectrum disorder (ASD), a collection of intricate multifactorial neurodevelopmental diseases. The immunological hypothesis is thought to have a significant role in the pathophysiology of autism and to explain the variations in clinical phenotypes and comorbidities that affect the severity and duration of the condition
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1-Careaga, M., Rogers, S., Hansen, R. L., Amaral, D. G., Van de Water, J., & Ashwood, P. (2017). Immune endophenotypes in children with autism spectrum disorder. Biological psychiatry, 81(5), 434-441. DOI: https://doi.org/10.1016/j.biopsych.2015.08.036
2-Krakowiak, P., Goines, P. E., Tancredi, D. J., Ashwood, P., Hansen, R. L., Hertz-Picciotto, I., & Van de Water, J. (2017). Neonatal cytokine profiles associated with autism spectrum disorder. Biological psychiatry, 81(5), 442-451. DOI: https://doi.org/10.1016/j.biopsych.2015.08.007
3-Lord, C., Elsabbagh, M., Baird, G., & Veenstra-Vanderweele, J. (2018). Autism spectrum disorder. The lancet, 392(10146), 508-520. DOI: https://doi.org/10.1016/S0140-6736(18)31129-2
4-Weizman, A. B. R. A. H. A. M., Weizman, R. O. N. I. T., Szekely, G. A., Wijsenbeek, H. E. N. R. I. C. U. S., & Livni, E. L. L. A. (1982). Abnormal immune response to brain tissue antigen in the syndrome of autism. Am J Psychiatry, 139(11), 1462-1465. DOI: https://doi.org/10.1176/ajp.139.11.1462
5-Cohly, H. H., & Panja, A. (2005). Immunological findings in autism. International review of neurobiology, 71, 317–341. https://doi.org/10.1016/s0074-7742(05)71013-8. DOI: https://doi.org/10.1016/S0074-7742(05)71013-8
6-Hosomichi, K., Shiina, T., Tajima, A., & Inoue, I. (2015). The impact of next-generation sequencing technologies on HLA research. Journal of human genetics, 60(11), 665-673. DOI: https://doi.org/10.1038/jhg.2015.102
7-Lokau, J., & Garbers, C. (2020). Biological functions and therapeutic opportunities of soluble cytokine receptors. Cytokine & growth factor reviews, 55, 94-108. DOI: https://doi.org/10.1016/j.cytogfr.2020.04.003
8-Ferreira, V. L., Borba, H. H., Bonetti, A. D. F., Leonart, L., & Pontarolo, R. (2018). Cytokines and interferons: types and functions. Autoantibodies and cytokines, 13. DOI: https://doi.org/10.5772/intechopen.74550
9-Conlon, K. C., Miljkovic, M. D., & Waldmann, T. A. (2019). Cytokines in the treatment of cancer. Journal of Interferon & Cytokine Research, 39(1), 6-21. DOI: https://doi.org/10.1089/jir.2018.0019
10-Oztan, O., Tutkun, L., Turksoy, V. A., Deniz, S., Dip, A., Iritas, S. B., ... & Alaguney, M. E. (2021). The relationship between impaired lung functions and cytokine levels in formaldehyde exposure. Archives of Environmental & Occupational Health, 76(5), 248-254. DOI: https://doi.org/10.1080/19338244.2020.1816883
11-Sorci, G., Lippens, C., Léchenault, C., & Faivre, B. (2017). Benefits of immune protection versus immunopathology costs: A synthesis from cytokine KO models. Infection, Genetics and Evolution, 54, 491-495. DOI: https://doi.org/10.1016/j.meegid.2017.08.014
12-Kawabe, T., Yi, J., Kawajiri, A., Hilligan, K., Fang, D., Ishii, N., ... & Sher, A. (2020). Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state. Nature communications, 11(1), 3366. DOI: https://doi.org/10.1038/s41467-020-17136-1
13-Meltzer, A., & Van de Water, J. (2017). The role of the immune system in autism spectrum disorder. Neuropsychopharmacology, 42(1), 284-298. DOI: https://doi.org/10.1038/npp.2016.158
14-Estes, M. L., & McAllister, A. K. (2016). Maternal immune activation: Implications for neuropsychiatric disorders. Science, 353(6301), 772-777. DOI: https://doi.org/10.1126/science.aag3194
15-Jones, K. L., & Van de Water, J. (2019). Maternal autoantibody related autism: mechanisms and pathways. Molecular psychiatry, 24(2), 252-265. DOI: https://doi.org/10.1038/s41380-018-0099-0
16-Upadhyay, S., Sharma, N., Gupta, K. B., & Dhiman, M. (2018). Role of immune system in tumor progression and carcinogenesis. Journal of cellular biochemistry, 119(7), 5028-5042. DOI: https://doi.org/10.1002/jcb.26663
17- Cruceriu, D., Baldasici, O., Balacescu, O., & Berindan-Neagoe, I. (2020). The dual role of tumor necrosis factor-alpha (TNF-α) in breast cancer: molecular insights and therapeutic approaches. Cellular Oncology, 43(1), 1-18. DOI: https://doi.org/10.1007/s13402-019-00489-1
18-Fara, A., Mitrev, Z., Rosalia, R. A., & Assas, B. M. (2020). Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines. Open biology, 10(9), 200160. DOI: https://doi.org/10.1098/rsob.200160
19-Kim, Y. S., Choi, J., & Yoon, B. E. (2020). Neuron-glia interactions in neurodevelopmental disorders. Cells, 9(10), 2176. DOI: https://doi.org/10.3390/cells9102176
20- . Pangrazzi L, Balasco L, Bozzi Y. Oxidative stress and immune system dysfunction in autism spectrum disorders. International journal of molecular sciences. 2020 May 6;21(9):3293. DOI: https://doi.org/10.3390/ijms21093293
21-Siniscalco D, Schultz S, Brigida AL, Antonucci N. Inflammation and neuro-immune dysregulations in autism spectrum disorders. Pharmaceuticals. 2018 Jun 4;11(2):56. DOI: https://doi.org/10.3390/ph11020056
22-Xu N, Li X, Zhong Y. Inflammatory cytokines: potential biomarkers of immunologic dysfunction in autism spectrum disorders. Mediators of inflammation. 2015 Oct;2015. DOI: https://doi.org/10.1155/2015/531518
23- Suzuki K, Matsuzaki H, Iwata K, Kameno Y, Shimmura C, Kawai S, Yoshihara Y, Wakuda T, Takebayashi K, Takagai S, Matsumoto K. Plasma cytokine profiles in subjects with highfunctioning autism spectrum disorders. PloS one. 2011 May 27;6(5):e20470. DOI: https://doi.org/10.1371/journal.pone.0020470
24- Ricci S, Businaro R, Ippoliti F, Lo Vasco VR, Massoni F, Onofri E, Troili GM, Pontecorvi V, Morelli M, Rapp Ricciardi M, Archer T. Altered cytokine and BDNF levels in autism spectrum disorder. Neurotoxicity research. 2013 Nov;24:491-501. DOI: https://doi.org/10.1007/s12640-013-9393-4
25- Alabdali A, Al-Ayadhi L, El-Ansary A. Association of social and cognitive impairment and biomarkers in autism spectrum disorders. Journal of neuroinflammation. 2014 Dec;11:1-4 DOI: https://doi.org/10.1186/1742-2094-11-4
26-Singh VK. Plasma increase of interleukin-12 and interferongamma. Pathological significance in autism. Journal of neuroimmunology. 1996 May 1;66(1-2):143-5. DOI: https://doi.org/10.1016/0165-5728(96)00014-8
27- Zhao H, Zhang H, Liu S, Luo W, Jiang Y, Gao J. Association of peripheral blood levels of cytokines with autism spectrum disorder: a meta-analysis. Frontiers in psychiatry. 2021 Jul 2;12:670200. DOI: https://doi.org/10.3389/fpsyt.2021.670200
28- Gomez-Fernandez A, de la Torre-Aguilar MJ, Gil-Campos M, Flores-Rojas K, Cruz-Rico MD, Martin-Borreguero P, Perez-Navero JL. Children with autism spectrum disorder with regression exhibit a different profile in plasma cytokines and adhesion molecules compared to children without such regression. Frontiers in pediatrics. 2018 Sep 26;6:264. DOI: https://doi.org/10.3389/fped.2018.00264
29- D’Mello C, Le T, Swain MG. Cerebral microglia recruit monocytes into the brain in response to tumor necrosis factorα signaling during peripheral organ inflammation. Journal of Neuroscience. 2009 Feb 18;29(7):2089-102. DOI: https://doi.org/10.1523/JNEUROSCI.3567-08.2009
30-Olmos G, Lladó J. Tumor necrosis factor alpha: a link between neuroinflammation and excitotoxicity. Mediators of inflammation. 2014 Oct;2014. DOI: https://doi.org/10.1155/2014/861231
31-Li Q, Zhou JM. The microbiota–gut–brain axis and its potential therapeutic role in autism spectrum disorder. Neuroscience. 2016 Jun 2;324:131-9. DOI: https://doi.org/10.1016/j.neuroscience.2016.03.013
32-Tural Hesapcioglu S, Kasak M, Cıtak Kurt AN, Ceylan MF. High monocyte level and low lymphocyte to monocyte ratio in autism spectrum disorders. International Journal of Developmental Disabilities. 2019 Mar 15;65(2):73-81. DOI: https://doi.org/10.1080/20473869.2017.1371369
33-Sari NP, Yudianita K, Haiqal MR, Akbar MF. The Diagnostic Value of Neutrophil-Lymphocyte Ratio in Diagnosis of Autism Spectrum Disorders. INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY. 2020 Sep 30;26(3):356-61. DOI: https://doi.org/10.24293/ijcpml.v26i3.1597
34-Kutlu A, Binici NC. Does increased neutrophil-lymphocyte ratio predict autism spectrum disorder?. Anadolu Psikiyatri Dergisi. 2018 Dec 1;19(6):607-14. DOI: https://doi.org/10.5455/apd.296339
35-Ellul P, Rosenzwajg M, Peyre H, Fourcade G, Mariotti-Ferrandiz E, Trebossen V, Klatzmann D, Delorme R. Regulatory T lymphocytes/Th17 lymphocytes imbalance in autism spectrum disorders: evidence from a meta-analysis. Molecular autism. 2021 Dec;12:1-7. DOI: https://doi.org/10.1186/s13229-021-00472-4
36-Harutyunyan AA, Harutyunyan HA, Yenkoyan KB. Novel probable glance at inflammatory scenario development in autistic pathology. Frontiers in Psychiatry. 2021 Dec 22;12:788779. DOI: https://doi.org/10.3389/fpsyt.2021.788779
37-Ashwood P, Corbett BA, Kantor A, Schulman H, Van de Water J, Amaral DG. In search of cellular immunophenotypes in the blood of children with autism. PloS one. 2011 May 4;6(5):e19299. DOI: https://doi.org/10.1371/journal.pone.0019299
38-Robinson-Agramonte MD, Noris García E, Fraga Guerra J, Vega Hurtado Y, Antonucci N, Semprún-Hernández N, Schultz S, Siniscalco D. Immune dysregulation in autism spectrum disorder: what do we know about it?. International journal of molecular sciences. 2022 Mar 11;23(6):3033. DOI: https://doi.org/10.3390/ijms23063033
39- Bijl, N., Thys, C., Wittevrongel, C., De la Marche, W., Devriendt, K., Peeters, H., ... & Freson, K. (2015). Platelet studies in autism spectrum disorder patients and first-degree relatives. Molecular autism, 6, 1-10. DOI: https://doi.org/10.1186/s13229-015-0051-y
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Copyright (c) 2025 duaa Abd Al hassan, luma Qasim Ali1, Samar Abdul Raheem AL-Gharrrawi

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