An Investigation into the Hematotoxin Effects of Sublethal Diazinon Doses in Albino Rats (Rattus norvegicus var. albinus)
DOI:
https://doi.org/10.36320/ajb/v17.i2.19508Keywords:
Diazinon, Hematological markers, Sublethal effectsAbstract
Diazinon, a hazardous organic insecticide, causes considerable dangers when released into the environment, notably to aquatic life and terrestrial animals. This study aims to examine the toxicological effects of diazinon on albino rats. (Rattus norvegicus var albinus), The emphasis is on deadly and sublethal concentrations. This study was carried out with albino rats kept in a controlled laboratory environment. The LD50 was determined using Probit analysis, resulting in an LD50 of 588 ppm body weight. For sub-lethal effects, rats were treated to two different dosages a dose (60 and 300 ppm) for a period of 30 days. Hematological markers were measured at intervals of 1, 15, and 30 days. The results indicate that there was a significant increase in the RBC, WBC, and HGB, in contrast with the PLT on the first day of exposure, which showed a significant decrease compared to the control group. These studies demonstrate Diazinon's toxic effect on albino rats, emphasizing its ability to damage hematological parameters at sublethal doses
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