Serum Biomarker Levels of Interleukin-18 and Monocyte Chemoattractant Protein-1 in Patients with Acute Coronary Syndrome
DOI:
https://doi.org/10.36320/ajb/v17.i3.20069Keywords:
Serum Biomarker Levels of Interleukin-18 and Monocyte Chemoattractant Protein-1 in Patients with Acute Coronary SyndromeAbstract
The present study aims to investigate serum biomarkers for all participants: seropositivity levels of interleukin-18 (IL-18) and monocyte chemoattractant protein-1 (MCP-1) by enzyme-linked immunosorbent assay (ELISA). The study involved 120 patients with coronary artery disease (CAD), including 90 patients with acute coronary syndrome (ACS) subdivided into 30 patients with STEMI, 30 with NSTEMI, and 30 with unstable angina (UA), and an additional 30 patients who had stable angina. The study was conducted as a case-control design at the Al-Najaf Center for Cardiovascular Surgery and Cardiac Catheterization from November 2023 to July 2024. Blood samples were collected via venipuncture, 3 mL to gel tubes for serum analyses, including troponin I, lipid profile, IL-18, MCP-1, and ROC curve analysis. The results showed that ACS patients had a significantly higher prevalence of dyslipidemia compared to controls, with the highest mean triglyceride level observed in the SA group (251.4 108.1mg/dl). In addition, the prevalence of diabetes was significantly higher in the ACS group than in the non-ACS group (p 0.001 and p = 0.001, respectively). Among the clinical subgroups, the SA patients had the highest prevalence of hypertension, followed by the USA group, then the STEMI group, and the lowest prevalence of TG. Moreover, among the SA and the USA groups, the mean TG level varied significantly among CAD groups (SA USA NSTMI STEMI). In conclusion, the findings in the present study revealed that IL-18 levels were significantly increased in the patients with ACS compared with the nonACS group.
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