The relationship between lipid levels and leptin concentration in obese adolescents compare with control group
DOI:
https://doi.org/10.36320/ajb/v18.i1.22683Keywords:
Lipid Profile , Leptin , ObeseAbstract
This study investigated the relationship between lipid metabolism and leptin concentration in obese adolescents. A total of 70 obese and 20 normal-weight adolescents [aged 14–19 years] were recruited from Iraqi schools. Serum lipid profile parameters [HDL, LDL, TG, VLDL, and total cholesterol] and leptin concentrations were measured. The results revealed decreased HDL, non-significant changes in LDL and cholesterol, and significant increases in TG and VLDL in obese adolescents. Unexpectedly, leptin levels were lower in obese participants compared to controls. These findings suggest that altered lipid metabolism may influence leptin regulation in obese adolescents
Downloads
References
1-Mohajan D, Mohajan HK. Obesity and its related diseases: a new escalating alarming in global health. Journal of Innovations in Medical Research. 2023 Mar 23;2[3]:12-23.
2-Rössner S. Obesity: the disease of the twenty-first century. International journal of obesity. 2002 Dec;26[4]:S2-4.
3-Sawyer SM, Azzopardi PS, Wickremarathne D, Patton GC. The age of adolescence. The lancet child & adolescent health. 2018 Mar 1;2[3]:223-8.
4-James PT, Leach R, Kalamara E, Shayeghi M. The worldwide obesity epidemic. Obesity research. 2001 Nov;9[S11]:228S-33S.
5-Musaiger AO, Al-Mufty BA, Al-Hazzaa HM. Eating habits, inactivity, and sedentary behavior among adolescents in Iraq: sex differences in the hidden risks of noncommunicable diseases. Food and nutrition bulletin. 2014 Mar;35[1]:12-9.
6-Mazzeo F. Current concept of obesity. Sport Science. 2016;9[2]:42-8.
7-Jabbar MA, Abdullah HM, Al-Rudaini RS. Prevalence and risk factors for obesity among secondary school students in Baghdad, Iraq. health.;4:6.
8-Lönnqvist F, Nordfors L, Jansson M, Thörne A, Schalling M, Arner P. Leptin secretion from adipose tissue in women. Relationship to plasma levels and gene expression. The Journal of clinical investigation. 1997 May 15;99[10]:2398-404.
9-Tritos NA, Mantzoros CS. Leptin: its role in obesity and beyond. Diabetologia. 1997 Nov;40[12]:1371-9.
10-Alsaffar SF, Jumaa HM, Baqer NN. Detection of Leptin and Ghrelin Hormones and the Expression of their Receptors in Iraqi Obese Individuals. Iraqi Journal of Science. 2024 Jan 30:36-42.
11-Liu D. High-Density Lipoprotein: From Biological Functions to Clinical. Apolipoproteins, Triglycerides and Cholesterol. 2020 Jun 17:13.
12-Dai L, Li S, Hao Q, Zhou R, Zhou H, Lei W, Kang H, Wu H, Li Y, Ma X. Low-density lipoprotein: a versatile nanoscale platform for targeted delivery. Nanoscale Advances. 2023;5[4]:1011-22.
13-Mardia IK, Syafril S. Correlation Between Small Dense Low-Density Lipoprotein and Risk Factor Cardiovascular on Obesity. Journal of Endocrinology, Tropical Medicine, and Infectious Disease. 2022:77-82.
14-Lee HC, Akhmedov A, Chen CH. Spotlight on very-low-density lipoprotein as a driver of cardiometabolic disorders: Implications for disease progression and mechanistic insights. Frontiers in cardiovascular medicine. 2022 Oct 4;9:993633.
15-Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, Caro JF. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New England Journal of Medicine. 1996 Feb 1;334[5]:292-5.
16-Considine RV. Serum immunoreactive leptin concentrations in normal weight and obese humans. N. Engl. J. Med.. 1995;834:294-5.
17-ALbaldawy MT, AL-Sallami AS, Alzeyadi M. pSerum HLA-G level as a prognostic marker and its correlation with some important markers for malignant and benign prostate hyperplasia. InAIP Conference Proceedings 2022 Dec 2 [Vol. 2547, No. 1, p. 020002]. AIP Publishing LLC.
18-AL-Sallami AS, Al-Shimerty DF, Rajab HH. Effect of anti-cardiolipin [IgG-IgM] and its relationship with the level of white blood cells in women undergoing intracytoplasmic sperm injection [ICSI]. InAIP Conference Proceedings 2022 Jan 11 [Vol. 2386, No. 1, p. 020034]. AIP Publishing LLC.
19-Al-Masaoodi RA, Al-Sallami AS, Al-Baseesee H. The relation between the RANKL and resistin in menopausal women with osteoporosis. InAIP Conference Proceedings 2019 Aug 22 [Vol. 2144, No. 1, p. 040012]. AIP Publishing LLC.
20-Yaghootkar H, Zhang Y, Spracklen CN, Karaderi T, Huang LO, Bradfield J, Schurmann C, Fine RS, Preuss MH, Kutalik Z, Wittemans LB. Genetic studies of leptin concentrations implicate leptin in the regulation of early adiposity. Diabetes. 2020 Dec 1;69[12]:2806-18.
21-Calcaterra V, Verduci E, Pascuzzi MC, Magenes VC, Fiore G, Di Profio E, Tenuta E, Bosetti A, Todisco CF, D’Auria E, Zuccotti G. Metabolic derangement in pediatric patient with obesity: The role of ketogenic diet as therapeutic tool. Nutrients. 2021 Aug 16;13[8]:2805.
22-Jung MK, Yoo EG. Hypertriglyceridemia in obese children and adolescents. Journal of obesity & metabolic syndrome. 2018 Sep 30;27[3]:143.
23-Berchtold P, Berger M, Jörgens V, Daweke C, Chantelau E. HDL-cholesterol levels in obesity. Int J Obes. 1981;5:1-0.
24-Al Zeyadi M, Al-Sallami AS, Albaldawy MT. Single Nucleotide Polymorphism in Protamine 1 and Protamine 2 genes in fertile and infertile for men of Al-Najaf City. InJournal of Physics: Conference Series 2019 Jul 1 [Vol. 1234, No. 1, p. 012081]. IOP Publishing.
25-Unger RH, Orci L. Lipotoxic diseases of nonadipose tissues in obesity. International Journal of Obesity. 2000 Nov;24[4]:S28-32.
26-Frühbeck G, Yumuk V. Obesity: a gateway disease with a rising prevalence. Obesity facts. 2014 May 1;7[Suppl. 2]:33-6.
Downloads
Published
Issue
Section
License
Copyright (c) 2026 alaaddin alsallami
This work is licensed under a Creative Commons Attribution 4.0 International License.
which allows users to copy, create extracts, abstracts, and new works from the Article, alter and revise the Article, and make commercial use of the Article (including reuse and/or resale of the Article by commercial entities), provided the user gives appropriate credit (with a link to the formal publication through the relevant DOI), provides a link to the license, indicates if changes were made and the licensor is not represented as endorsing the use made of the work.
