Determination the IL-10 serum level for the T1DM al-diwanyah patients
DOI:
https://doi.org/10.36320/ajb/v9.i2.7584Keywords:
IL-10, male, female, T1DMAbstract
The autoimmune disease T1DM (Type 1 diabetes mellitus) consider as important endocrine disorder described by the damage of beta cells of pancreatic islets. There is confirmation the IL-10 is a significant player on both immunity arms: innate and adaptive immunity. This study aimed to determined the essential role of IL-10 serum in the T1DM al-diwanyah patients as a vital immune factor for prevention and treatment of T1DM.
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Szablewski, L.(2014). Role of immune system in type 1 diabetes mellitus pathogenesis. Int Immunopharmacol.22:182–91.
Morran MP, Vonberg A, Khadra A, Pietropaolo M.(2015). Immunogenetics of type 1 diabetes mellitus. Mol Aspects Med.42:42–60. [PMC free article] [PubMed]
Galleri L, Sebastiani G, Vendrame F, Grieco FA, Spagnuolo I, Dotta F.(2012). Viral infections and diabetes. Adv Exp Med Biol.771:252–71.
Tchorzewski H, Glowacka E, Banasik M, Lewkowicz P, Szalapska-Zawodniak M.(2001). Activated T lymphocytes from patients with high risk of type I diabetes mellitus have different ability to produce interferon-gamma, interleukin-6 and interleukin-10 and undergo anti-CD95 induced apoptosis after insulin stimulation. Immunology Letters.75(3):225–234.
Roep BO, Peakman M: (2012).Antigen targets of type 1 diabetes autoimmunity. Cold Spring Harb Perspect Med 2:a007781.
He, J.S.; Xie, P.S.; Luo DS, Sun, C.J.; Zhang, Y.G. and Liu, F.X.(2014). Role of immune dysfunction in pathogenesis of type 1 diabetes mellitus in children. Asian Pac J Trop Med. 7(10): 823 - 6.
Atkinson, M. A., and E. H. Leiter.(1999). The NOD mouse model of type 1diabetes: as good as it gets? Nat. Med. 5:601.
Serreze, D. V.; Chapman, H. D.; Post, C. M.; Johnson, E. A.; Suarez-Pinzon, W. L. and Rabinovitch, A.(2001). Th1 to Th2 cytokine shifts in nonobese diabetic mice: some times an outcome rather than the cause of diabetes resistance elicited by immunostimulation. J.Immunology.166: 1352-1359.
Ankit, S.; Sam Khosraviani, S. N.; Divya M.; Thomas D. and Abdel Rahim A. H. (2015). Interleukin-10 paradox: A potent immunoregulatory cytokine that has been difficult to harness for immunotherapy. Cytokine. 74(1): 27–34.
Dokter WH, Koopmans SB, Vellenga E.(1996). Effects of IL-10 and IL-4 on LPS-induced transcription factors (AP-1, NF-IL-6, NFjB) which are involved in IL-6 regulation. Leukemia 10: 1308.
Murai, M. et al.(2009). Interleukin 10 acts on regulatory T cells to maintain expression of the transcription factor Foxp3 and suppressive function in mice with colitis. Nat Immunol. 10, 1178–1184.
Moore, K. W., M. de Waal, R. L. Coffman, and A. O’Garra. (2001). Interleukin-10 and the interleukin-10 receptor. Annu. Rev. Immunol. 19:683.
Jasem, M. A. (2013). Autoantibodies and Cytokines Levels in Type 1 Diabetic Patient. The Iraqi postgraduate medical journal. 12(3): 351-08.
Szelachowska, M., A. Kretowski, and I. Kinalska.(1998). Decreased in vitro IL-4 and IL-10 production by peripheral blood in first degree relatives at high risk of diabetes type-I. Horm. Metab. Res. 30:526.
J in ,S.,; Pu,S.;’, Dao,S.; Cheng,J.; Yu, G.; Fu,X.(2014). Role of immune dysfunction in pathogenesis of type 1 diabetes mellitus in children. asian pacific Journal of tropical medicine.823-826.
Saleh, E. M. (2009). Cytokines Profile in Newly Diagnosed Children with Type1 Diabetes Mellitus. J Fac Med Baghdad. 51(3):295-9.
Korholz D, Banning U, Bonig H, et al.(1997). The role of Interleukin-10 in IL-15-mediated T cell responses. Blood . 90: 4513.
Schloot, N. C.; Hanifi-Moghaddam, P.; Goebel, C.; et al.(2002). Serum IFN-gamma and IL-10 levels are associated with disease progression in nonobese diabetic mice. Diabetes Metab. Res. Rev.18(1): 64-70.
Gianani, R. and Sarvetnick, N.(1996). Viruses, cytokines, antigens and autoimmunity. Proc. Natl. Acad. Sci. USA. 93: 2257-2259.
Wogensen, L.; Lee, M. S. and Sarvetnick, N.(1994). Production of interleukin-10 by islet cells accelerate immune-mediated destruction of beta-cells in nonobese diabetes mice. J. Exp. Med.179: 1379-1384.
Balasa, B.; Davies, J. D.; Lee, J.; Good, A.; Yeung, B. T. and Sarvetnick, N.(1998) IL-10 impacts autoimmune diabetes via a CD8+ T-cell pathway circumventing the requirement for CD4+T and B lymphocytes. The Journal of Immunology.161: 4420-4427.
Lowe PR, Galley HF, Abdel-Fattah A, Webster NR. (2003).Influence of Interleukin-10 polymorphism on Interleukin-10 expression and survival in critically ill patients. Crit Care Med .31: 34.
Yeh FL, Shen HD, Fang RH.(2002). Deficient transforming growth factor b and interleukin-10 responses contribute to the septic death of burned patients. Burns. 28: 631.
Carey AJ, Tan CK, Ulett GC.(2012). Infection-induced IL-10 and JAK-STAT: A review of the molecular circuitry controlling immune hyperactivity in response to pathogenic microbes. JAKSTAT. 1:159–67.
Moritani, M., K. Yoshimoto, F. Tashiro, C. Hashimoto, J. Miyazaki, S. Ii, E. Kudo, H. Iwahana, Y. Hayashi, and T. Sano.( 1994). Transgenic expression of IL-10 in pancreatic islet A cells accelerates autoimmune insulitis and diabetes in non-obese diabetic mice. Int. Immunol. 6:1927.
Alleva, D. G., R. P. Pavlovich, C. Grant, S. B. Kaser, and D. I. Beller.(2000). Aberrant macrophage cytokine production is a conserved feature among autoimmune-prone mouse strains: elevated interleukin (IL)-12 and an imbalance in tumor necrosis factor-alpha and IL-10 define a unique cytokine profile in macrophages from young nonobese diabetic mice. Diabetes 49:1106.
Pakala, S. V., M. D. Kurrer, and J. D. Katz.(1997). T helper 2 (Th2) T cells induce acute pancreatis and diabetes in immune-compromised nonobese diabetic (NOD) mice. J. Exp. Med. 186:299–306.
Almawi, W. Y.; Tamim, H. and Azar, S. T.(1999) Thelper type 1 and 2 cytokines mediate the onset and progression of type 1 (insulin-dependent) diabetes. The Journal of Clinical Endocrinology and Metabolism.84: 1497-1502.
oltesz G, Patterson CC, Dahlquist G. (2007). Worldwide childhood type 1 diabetes incidence--what can we learn from epidemiology? Pediatr Diabetes;8 (6):6–14.
Liva, S.M. and Voskuhl,R.R.(2001). Testosterone Acts Directly on CD4_T Lymphocytes to Increase IL-10 Production. The journal of immunology. 167:2060-2067.
Huxley R, Barzi F, Woodward M.(2006) Excess risk of fatal coronary heart disease associated with diabetes in men and women: meta-analysis of 37 prospective cohort studies. BMJ.332:73-78.
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