Some diagnostic aspects, using CD markers, in young Iraqi children with visceral leishmaniasis
DOI:
https://doi.org/10.36320/ajb/v9.i2.7595Keywords:
visceral leishmaniasis, CD – markersAbstract
The lymphocytic phenotypes involved in the pathogenesis of visceral leishmaniasis (VL) in Iraqi children have recently been investigated, in a study based on cluster-differentiation (CD) markers . Each case of VL investigated was confirmed serologically by the immunochromatography with rk – 39 antigen strip test (dipstick assay) . A significant decrease was found in number of CD3 and CD4 cells in VL patients compared to the healthy control group, while the results showed that there was a significant increase in CD8 lymphocytes with VL patients in comparison to the control group . The CD4/CD8 ratio was lower in VL patients than that of the control group . There was a relative increase in CD22 of VL patients compared to the control group, but was not significant . There was no significant differnce in all types of CD cells percentage of VL in relation to some clinical parameters such as gender and age . Follow up of the patients showed there was a significant increase in the percentage of CD3, CD4, and CD4/CD8 ratio at the end of therapy . A relative decrease in CD22 but still more than control group .
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Copyright (c) 2017 Jasim H. Taher, Shahlaa A. Shake, Randa S. Majeed, Yosser A. Hachim
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