Effect of Prazosin Hydrochloride in Reproductive performance of Albino Male Rats
DOI:
https://doi.org/10.36320/ajb/v9.i2.7597Keywords:
prazosin hydrochloride, FSH, TestosteroneAbstract
This study aims to evaluate side effects of prazosin hydrochloride in fertility of male rats. Study groups were received orally graded dose of the prazosin hydrochloride (20,40, 80) mg/kg for 8-weeks, after end experimental, the treated group show significant decrement in testosterone and luteinizing hormone levels and decrement in sperm count. Also it causes decreased in follicle stimulating hormone level and testicular morphology, Sperm viability and motility. the body weight was decreased in the treated groups compare with control group, and decrease in weight of the tests, seminal vesicles and prostate gland compare with control group. The present study concluded that the prazosin hydrochloride possessed as anti-androgenic and anti spermatogenic affects.
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Ahmed, Z.; Khan, M. S.; Khan, M. A. and Haq, A. (2010) Seminal fructose in various classes of infertile patients Jamil Ur Rahman ., PP: 6-1 alone or in cobination with testosterone . Endocrinology, 44 :509-517.
Bellentani FF, Fernandes GS, Perobelli JE, Pacini ES, Kiguti LR, et al. (2011) Acceleration of sperm transit time and reduction of sperm reserves in the epididymis of rats exposed to sibutramine. J Androl 32: 718–724.
Frishman ,WH. ;and Jorde ,U .(2000) .β-adrenergic blockers. In: Oparil S and Weber MA (eds) Hypertension. Companion to Brenner’s and Rector’s the kidney. W.B. Saunders Company, London, 590–594.
Giuliano A , F. (2006 ) Impact of medical treatments for benign prostatic hyperplasia on sexual function. BJU. Int. ;97(2):34–38.
Giuliano, F. ; Bernabé, J.; Droupy ,S.; Alexandre, L. and Allard, J. A. (2004) comparison of the effects of tamsulosin and alfuzosin on neutrally evoked increases in bladder neck and seminal vesicle pressure in rats. BJU. Int; 93: 605–8 .
Haywood, M.; Spaliver, J; Jimenez, M. ; King, N. J. C. ; Handelsman, D.J. and Allan, C.M. (2003) Sertoli and germ cell development in hypogonodal (hpg) mice experesing transgenic follicle stimulating hormone alone or in cobination with testosterone . Endocrinology, 44 :509-517.
Mocktary, M.; Shariati, M. and Amiri, J. (2007) Effect of Tamsulosin on serum testosterone and gonadotropins concentration in adult male rats. Journal of Rafsenjan university of medical sciences., PP:6(1):1-6.
Gonzales, G. F. (2001) Function of seminal vesicles and their role on male fertility. Asian J Androl. 2001 Dec;3(4):251-8.
Hafez, E. (1987) Reproduction in farm animals . 5 th(ed.) Lea andFibiger.Philadelphia .pp: 457-461.
Joshi, M. & Ambaya, R. (1968) Effect of alkaloids from Vinica rosa onspermatogenesis in male rat indian journal of expermintal biology.,pp: 6:256 -7.
Moffat, A.C.;Osselton, M.D.; and Widdop, B. (2005).Clarke҆s Analysis of Drugs and Poisons, Pharmaceutical press.
Neal, B.;MacMahon, S. ; and Chapman, N. (2000).Effects of ACE inhibitors, calcium antagonists, and other blood-pressure-lowering drugs: results of prospectively designed overviews of randomised trials. Blood Pressure Lowering Treatment Trialists' Collaboration. Lancet.356 (9246):1955-64.
Patel DB, Patel NJ. Validated RP-HPLC and TLC methods for simultaneous estimation of tamsulosin hydrochloride and finasteride in combined dosage forms. Acta pharm 2010; 60:197-205.
Steel, R. O. D. ;and Torrie, J.I.I. (1960). Principles and produces of statistics. New York: McGraw-Hill Book Company. USA.
Robaire B HB, Orgebin-Crist MC (2006) The epididymis. In: Elsevier, editor. Knobil and Neill’s Physiology of Reproduction: Neill JD. 1071–1148.
Brophy, K. M.; Scrlelett-Ferguson, H. and Webber, K. S. (2010) Clinical drug therapy for canadian practice 3ed (ed). Lippincott wiliams &Wilkins, Philadelphia.PP:292-269.
Nara N, McCulloch E. The proliferation in suspension of the progenitors of the blast cells in a cutemyeloblastic leukemia. Blood 1985; 65:1484-1492.
Dale B, Elder K. Spermoocyte interaction, sperm parameters and sperm preparation techniques. In: in vitro fertilization, Cambridge university Press. UK,1997.
Vogl AW, Pfeiffer DC, Mulholland D, Kimel G, Guttman J. Unique and multifunctional adhesion junctions in the testis: ectoplasmic specializations. Arch Histol Cyto 2000; 63:1–15.
Smith JT, Mayer DT. Evaluation of sperm concentration by the homocytometer method. Comparison of four counting fluid. J Fert Steril, 1995; 6: 217-275.
Ratensooria WD, Wadsworth RM. Tamsulosin, aselectivealpha-1 adrenoceptor antagonists inhibits fertility of male rats. Andrologia 1994; 26: 107-10.
Lee, S. W. H. ; Men, L. L.; Kahay, Y.; Yee, V. L. and John, N. K.(2008) Alpha-Blocker therapy for chronic prostatitis /chronic pelvic painsyndrom In: Schoskes, D. A. (ed.) chronic prostatitischronic pelvic painsyndrome. Human press , a part of springer science, USA. PP: 85 91 .
Hisasue, S.; Furuya, R.; Itoh, N.; Kobayashi , K. and Furuya , S.( 2006) Ejaculatory disorder caused by alpha-1 adrenoceptor antagonists is not retrograde ejaculation but a loss of seminal emission. J. Urol; 13: 1311.
Hellstrom, W. J. and Sikka, S. C. (2007) Effect of acute treatment withTamsulosin versus Alfuzosin on ejaculatory function in normal vounteers. J urol .176(4 pt 1):1529-33
Nobile, A. J.; Chess-Williams, R. and Couldwell, C. (1997) The effects ofTamsulosin , a high affinity antagonists at afunctional alpha 1A-and alpha 1D–adrenoceptor subtypes . BrJ pharmacol ., PP:120:231-238.
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