Immunological effects of Flutamide and cyproterone acetate used two Anti-prostate cancer in Rats

Abstract

This  present study was performed to examine the effects of two drugs of anticancer of prostate (flutamide & cyproterone acetate) on some immunological in albino male rats. The animals were divided into two groups, first treatment groups gives orally flutamide at 25 and 15 mg/kg/day and  two group gives orally cyproterone acetate at 10 and 5 mg/kg/day, and control divided into two groups,first group gives normal saline and two group gives corn oil and all groups gives orally for 28 days.stady immunological parameters including the conceneration IgG, IgM ,IgA, γ-golbulin, IL-4, IL10 and measuring phagocytic activity also measuring total protein.  Furtheremore, The effects of these drugs have been also tested on some blood components including; WBC, differenatial WBCs in treatments and control groups (normal saline & corn oil) of rats .

The flutamide (25,15 mg/kg) and cyproterone acetate (10,5 mg/kg) produced significant decreases in total protein except WBC count which show significantly increases, but both  drugs above don't effect in, IgA, IgM, IL-10 and phacocytic activity, on the other hand Flu (25 mg/kg) only  produced siginificantly increase  in level of IL-4 and siginificantly decrease in IgG and globulin-γ concentration, furtheremore, CPA (10 mg/kg) cause only siginificantly increase in concentration of IgG and neutrophils and siginificantly decrease in lymphocytes .  The results of this study refer that the two drugs show  significant change in blood components intreated rats compared with control groups, high dose of Flu showed siginificant change in immunological parameters.