Antibacterial effect of Cappariloside (C22H28N2O11) and Vitexlactam (C22H35NO4) alkaloids compounds isolation from Capparis spinosa roots & Vitex agnus-castus fruits.
DOI:
https://doi.org/10.36320/ajb/v7.i1.8092Keywords:
Cappariloside, Vitexlactam, Capparis spinosaAbstract
The isolation of alkaloids compounds from Capparis spinosa roots and Vitex agnus-castus fruits as crystal yellowish white powder. The chemical and physical properties of isolated alkaloids compounds were studied by using thin layer chromatography (TLC), melting point (MP), ultraviolet spectrum (UV) and FTIR spectrum. The isolated alkaloids compounds are shown high antibacterial activity against pathogenic bacteria (S. aureus, P. aeruginosa, P. stutzeri, E. aeruginosa, S. viridans, and S. pneuomonia). The results explained broad spectrum antibacterial property of alkaloids compounds against all pathogenic bacteria.
Downloads
References
Calis, I.; Kuruuzum, A. & RRedi, P. (1999).1H-Indole-3 acetonitrile glycosides from Capparis spinosa fruits. Phytochemistry, 50: 1205-1208. DOI: https://doi.org/10.1016/S0031-9422(98)00669-4
Caron, C.; Hoizey, M. J.; Le Men-Olivier, L.; Massiot, G.; Zeches, M.; Choisy, C.; Le Magrex, E. & Verpoorte, R. (1988). Antimicrobial and antifungal activities of quasi-dimeric and related alkaloids. PlantaMedica,54(4): 409–412. DOI: https://doi.org/10.1055/s-2006-962483
Donald, L.; Pavia, G. M.; Lampman, G.S.; Kriz, J. R. & Vyvyan. (2009). Introduction to Spectroscopy. 4th ed. Western Washington University U.S. A.: 656 pp.
Dubouzet, J. G.; Morishige, T.; Fujii, N.; An C. I.; Fukusaki, E.; Ifuku, K. & Sato, F. (2005). Transient RNA silencing of scoulerine 9-O-methyltransferase expression by double stranded RNA in Coptis japonica protoplasts. Biosci. Biotechnol. Biochem, 69(1): 63-70. DOI: https://doi.org/10.1271/bbb.69.63
Egharevba, H. O.; Kunle, O. F.; Iliya, I.; Orji, P. N.; Abdullahi, M. S.; Okwute, S. K.; Okogun, J. I. (2010). Phytochemical analysis and antimicrobial activity of Punica granatum L. (fruit and leaves). New York Scie. J. 3 (12): 91-98.
Ekundayo, O.; Laakso, I.; Holopainen, M.; Hiltunen, R.; Oguntimein, B. & Kauppinen, V. (1990). The chemical composition and antimicrobial activity of the leaf oil of Vitex agnus-castus L. J. Essent. Oil Res. 2 (3): 115-119. DOI: https://doi.org/10.1080/10412905.1990.9697840
Elisabetsky, E. and Costa-Campos, L. (2006). The alkaloid alstonine: A review of its pharmacological properties. Evid. Based Complement, alternative Medicine 3: 39-48. DOI: https://doi.org/10.1093/ecam/nek011
Eltayeb, E.; Al-Ansari, A. & Roddick, J. (1997). Changes in the steroidal alkaloid solasodine during development of Solanum incanum. Phytochem, 46: 489-494. DOI: https://doi.org/10.1016/S0031-9422(97)00323-3
Evans, W.C. (ed.). (1999). Trease and Evan's pharmacognosy. 14th ed. W. B. Saunders Company Ltd. UK. experimental. AL-Mousel Univ. (In Arabic).
Fatima, A.; Modolo, L.V.; Conegero, L.S.; Pilli, R.A.; Ferreira, C.V.; Kohn, L.K. & Carvalho, J.E. (2006). Lactones and their derivatives: biological activities, mechanisms of action and potential leads for drug design. Curr. Med. Chem. 13:3371-3384. DOI: https://doi.org/10.2174/092986706779010298
Gershenzon, J. (1998). Plant Defenses: Surface properties and secondary metabolites. In plant physiology (ed. Lincoln, T. and Zeiger, E.), USA. P.347-376.
Harborne, J. B. (1984). Phytochemical methods.; A Guide to Modern Techniques of Plant Analysis, 2nd ed. Chapman and Hall, London. DOI: https://doi.org/10.1007/978-94-009-5570-7_1
Ibrahim, O. M. (2012). Evaluation of antibacterial activity of Capparis spinosa (Al-Kabara) and Aloe vera extracts against isolates bacterial skin wound infections in vitro and in vivo. Kufa Journal for Veterinary Medical Sciences Vol. 3 No. 2: 23-35. DOI: https://doi.org/10.36326/kjvs/2012/v3i23938
Ismaeil, A. S. (2011). Effect of black seed alkaloids against some pathogenic bacteria, vol.22, No. 4 pp 9-16. DOI: https://doi.org/10.33899/rjs.2011.6800
Kaufman, B.; Cseke, L. and Okubo, A. (1999). Bioseparation of Compounds .In Kaufman P.; Cseke L.; Duke J. and Brielmann H. Natural products from plants. CRC Press, LLC.207-241. DOI: https://doi.org/10.1201/9781420049350.ch7
Keroynz, N. & Anthrykin, J. (1986). Identidcation organic compounds. Translated by Yasin shandallah and Nazar AL Jubory. AL-Mousel Univ. 225 (In Arabic).
Khalaf, N.A.; Shakya, A.K.; Al-othman, A.; Ahbar, Z. & Farah, H.( 2007). Antioxdidant activity of some common plants. Turk. J. Biol. 31:1-5.
Kluza, J.; Mazinghien, R.; Degardin, K.; Lansiaux, A. & Bailly, C. (2005). Induction of apoptosis by the plant alkaloid sampangine in human HL-60 leukemia cells is mediated by reactive oxygen species. Euro J Pharma, 525(1–3): 32–40. DOI: https://doi.org/10.1016/j.ejphar.2005.09.050
Li, S.; Qiu, S.; Yao, P.; Sun, H.; Fong, H. and Zhang, H. (2013). Compounds from the Fruits of tha Popular European Medicinal Plant Vitex agnus-castus in Chemoprevention via NADP (H): Qxidoreductase Type 1 Induction, Handawi Publshing Corporation, Evidence-Based Complementary and Alternative Medicine, Vol. Article ID 432829, 7 pages. DOI: https://doi.org/10.1155/2013/432829
Lowy, F. D. (1998). Staphylococcus aureus infections. N Engl J Med 339, 520-532. DOI: https://doi.org/10.1056/NEJM199808203390806
Nwachukwu, E. & Uzoeto, H. O. (2010). Antimicrobial activities of leaf of Vitex doniana and Cajanus on some bacteria; Researcher 2 (3): 2460–2465.
Pick, N.; Rawat, M.; Arad, D.; Lan, J.; Fan, J.; Kende, A. and Gay, Y. (2006). In Vitro properties of antimicrobial bromotyrosine alkaloids, Journal of Medical Microbiology, 55, 407-415. DOI: https://doi.org/10.1099/jmm.0.46319-0
Roberts, M. F. & Wink, M. (1998). Alkaloids: Biochemistry, Ecology, and Medicinal Applications. NewYork. DOI: https://doi.org/10.1007/978-1-4757-2905-4
Shah, P. M. (2005). The need for new therapeutic agents: what is in pipeline? Clin. Microbiol. Infect. 11:36-42. DOI: https://doi.org/10.1111/j.1469-0691.2005.01141.x
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2016 Ahmad Abies, Diana Basim Abdul hameed, Mayada Farahan
This work is licensed under a Creative Commons Attribution 4.0 International License.
which allows users to copy, create extracts, abstracts, and new works from the Article, alter and revise the Article, and make commercial use of the Article (including reuse and/or resale of the Article by commercial entities), provided the user gives appropriate credit (with a link to the formal publication through the relevant DOI), provides a link to the license, indicates if changes were made and the licensor is not represented as endorsing the use made of the work.