A Comparison between the Acute Effects of Coxis on renal function with that of diclofenac Sodium in patients with rheumatological disorders

Authors

  • Kalaf . Abdullah Sayer Alkafaji 1medical physician – Alsharqat hospital - Alsharqat -salah-Eldin -Iraq

DOI:

https://doi.org/10.36320/ajb/v10.i3.8114

Keywords:

Celecoxib ( COX-2 inhibitors), Renal Function, Diclofenac Sodium

Abstract

The aim of this study was identify the effect of (coxibs) on renal function in comparison to the traditional (NSAIDs) to provide more insight on this issue. Particular emphasis has been paid to the possible acute renal toxicities such as acute decline in renal function, hyperkalaemia, hypertension and sodium and water retension, the study was conducted during the period from (February –August) 2018 , Rheumatological out-patient clinic in Ibn-Sina Teaching Hospital in Mosul. patients and methods : Eighty patients with different rheumatological disorders who have no history of pre-existing renal disease.

Downloads

Download data is not yet available.

References

Braum C, Kennedy DL, Forbes MB, Utilization of non-steroidal anti-inflammatory drugs Arthritis Rheum 1985; 28:686-692.

Phillips AC, Polisson R P. Simon LS, NSAIDs and the elderly: toxicity and the economic implications. Drugs Aging 1997; 10:119-130.

Brooks PM, Day RO, Non-steroidal anti inflammatory drugs: difference and similarities, N Engl J med 1991; 324:1716-1725.

Furst DE, Are there differences among non-steroidal anti inflammatory drugs. Arthritis Rheum 1997; 40:1940-1943.

Wolfe MM , Lichtenstin DR , Singh G. Castro intestinal toxicity of the non-steroidal anti inflammatory drugs N Engl MED 1999;340:1888-1899.

Whelton A, Schulman G, Wallemark C, Drower EJ, Isakson PC , Veburg KM , Geis SG , Effects of Celecoxib and naproxene on renal function in the eledery. Arch intern Med .2000; 60: 1465-1470.

Swan SK , Rndy DW , Lasseter KC , et al. Effects of cyclo oxgenasc-2 inhibition on Renal function in eldery persons receiving a low –salt diet . Ann int Med .2000; 133:1-9 [Medline].

Rosset J et al. Renal effects of selective cyclooxygenase-2 inhibition in normotensive salt-depleted subjects. Clin Pharmacol Ther. 1999. 66: 76.

Harris RC. Cyclo oxygenasc -2 in the kidney. J AM SOC Nephrol .2000;11:2387-2394 [ free full text ]

James L. Bruning, B.L. Kintz, Scott Fore Smand and company illinois. Computational Hand book of statistics second edition, 1997;10-16.

Whelton A. Nephotoxicity of non- steroidal anti-inflammatory drugs: physiologic foundations and clinical implications Am J med 1999; 106.

Barker DC , Anderson S, Baird B , Compbell WB, Effects of ibnprofen , naproxene , and sulindac on prostaglandins in men . kidny Int 1985;27:66-73.

Toto RD, Anderson SA , Brown–Cant wright D, Kokko JP, Brater DC , effects of acute and chronic dosing of NSAIDs in patients with renal insfficincy . Kidney Int 1986; 30:760-768.

Fulgraff, G., and Meiforth, A.. Effects of prostaglandin E2 on excreation and reabsorption of sodium and fluid in rat kidney ( micropuncture studies ) plfugers Arch. 1977, 330;243.

Ganguli, M., Tobian, L., Azar, S., et al. Evidence that protasglandin synthesis inhibitors increase the concentration of sodium and chloride in rat renal medulla. Circ. Res. 1977, 40:135.

Shimizu, K. Kurosowa, T., Maeda, T., et al. Free water excretion and washout of renal medullary urea by prostaglandin E JPM. Heart J.1969, 10: 473.

Finding J.W, Beck Strom, D., And Rawsthrone, L. Indomethacin-induced hyperkalaemia in three patients with gouty arthritis. J.A.M.A. , 1980. 244:1127.

Goldzer R.C., Coodley, E.L., Rosner, M.J. et al. hyperkalaemia associated with Indomethacin Arch. intern Med.1980.141:802 .

Tan, S.Y., Franco, R., Stockard, H., Indomethacin Induced prostaglandin inhibition with hyperkalaemia .A reversible cause of hyproeninemic hypoasldosteronism. Ann. Intern. Med. 1979.90:783.

Pratt. J.H. Role of Angiotension II in potassium mediated stimulation of aldosterom secrction in the dog. J. Clin. Invest. .1982.70:667.

Smith WL, Garavito MR , Dewitt DL. Prostaglandin endoperoxide H syntheses ( cyclooxygenase-1 and -2) J. Biological chemistry . 1996;271: 33157-33160. 22. Tektook , N.K.(2005).Bacteriological and Serological study in Diabetic patients with urinary tract infections and diabetic retinopathy,Al-Mustansiriyah University - College of Science.

Downloads

Published

2018-10-25

How to Cite

Abdullah Sayer Alkafaj, K. (2018). A Comparison between the Acute Effects of Coxis on renal function with that of diclofenac Sodium in patients with rheumatological disorders. Al-Kufa University Journal for Biology, 10(3), 56–73. https://doi.org/10.36320/ajb/v10.i3.8114

Similar Articles

1 2 3 4 > >> 

You may also start an advanced similarity search for this article.