study the relationship between CRP and Ferritin in people infection with COVID-19 in AL-Najaf Governorate, Iraq.
DOI:
https://doi.org/10.36320/ajb/v12.i1.8147Abstract
Coronavirus (COVID-19) is a viral disease transmitted from person to others by coughing and sneezing droplets.COVID-19 is a new virus spread over the world symptoms of COVID-19 that can range from mild to severe disease and can develop into multi-organ failures, caused death .
Method:- The study included 68 people coming to the AL-Najaf Hospitals, who are suffering from infection by COVID-19 for a period of 2 months, from April to May month 2020. Draw 5 ml of blood for the measurement of CRP and Ferritin in patients' blood.
Result:- The current study showed that infection with Covid-19 is affected by the age factor of the patient, the age group (40-46) years was the most affected group, where the rate of infection being (38. 24).)% also, the study showed the sex factor was an effect on spread infection where the men infection was more than from women. The study also showed that the injury caused a significant increase (p <0.001) in the Ferritin level in both sexes compared to the healthy group (515, 222.382) ng/ml respectively in the Men and(470, 71 ) ng/ml respectively in the women. also, a significant increase in CRP level compared with the healthy group ( 44.82,3.41) IU/ ml respectively.
Downloads
References
Chan JF, Yuan S, Kok KH, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet 2020;395:514-23. DOI: https://doi.org/10.1016/S0140-6736(20)30154-9
Xu X, Chen P, Wang J, et al. Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission. Sci China Life Sci 2020;63:457-60 DOI: https://doi.org/10.1007/s11427-020-1637-5
Chen CC, Lee IK, Liu JW, Huang SY, Wang L. Utility of C-reactive protein levels for early prediction of dengue severity in adults. Biomed Res Int. 2015;2015:936062. DOI: https://doi.org/10.1155/2015/936062
Eppy E, Suhendro S, Nainggolan L, Rumende CM. The differences between interleukin-6 and c-reactive protein levels among adult patients of dengue infection with and without plasma leakage. Acta Med Indones. 2016;48(1):3–9.
“Coronavirus Disease (COVID-19) Pandemic,” Mar. 2020.[Online]. Available: http://www.euro.who.int/en/health-topics/healthemergencies/coronavirus-covid-19/novel-coronavirus-2019-ncov
H. Heesterbeek, R. M. Anderson, V. Andreasen, S. Bansal, D. De Angelis,C. Dye, K. T. D. Eames, W. J. Edmunds, S. D. W. Frost, S. Funk, T. Hollingsworth, T. House, V. Isham, P. Klepac, J. Lessler, J. O. Lloyd-Smith, C. J. E. Metcalf, D. Mollison, L. Pellis, J. R. C. Pulliam, M. G. Roberts, and C. Viboud, “Modeling infectious disease dynamics in the complex landscape of global health,” Science, vol. 347, no. 6227, Mar.2015 DOI: https://doi.org/10.1126/science.aaa4339
Huang et.al.2020. A retrospective analysis of the epidemiology, clinical manifestations, and imaging characteristics of familial cluster-onset COVID-19. Ann Transl Med 2020;8(12):747 DOI: https://doi.org/10.21037/atm-20-3759
A. Casadevall, L. A. Pirofski, The convalescent sera option for containing COVID-19. J Clin Invest,(2020). DOI: https://doi.org/10.1172/JCI138003
K. Duan, B. Liu, C. Li, H. Zhang, T. Yu, J. Qu, M. Zhou, L. Chen, S. Meng, Y. Hu, C. Peng, M. Yuan, J. Huang, Z. Wang, J. Yu, X. Gao, D. Wang, X. Yu, L. Li, J. Zhang, X. Wu, B. Li, Y. Xu, W. Chen, Y. Peng, Y. Hu, L. Lin, X. Liu, S. Huang, Z. Zhou, L. Zhang, Y. Wang, Z. Zhang, K. Deng, Z. Xia, Q. Gong, W. Zhang, X. Zheng, Y. Liu, H. Yang, D. Zhou, D. Yu, J. Hou, Z. Shi, S. Chen, Z. Chen, X. Zhang, X. Yang, Effectiveness of convalescent plasma therapy in severe COVID-19 patients. Proc Natl Acad Sci U S A 117,9490-9496 (2020). DOI: https://doi.org/10.1073/pnas.2004168117
M. J. Joyner, R. S. Wright, D. Fairweather, J. W. Senefeld, K. A. Bruno, S. A. Klassen, R. E. Carter, A. M. Klompas, C. C. Wiggins, J. R. Shepherd, R. F. Rea, E. R. Whelan, A. J. Clayburn , M. R. Spiegel, P. W. Johnson, E. R. Lesser, S. E. Baker, K. F. Larson, J. G. Ripoll, K. J. Andersen, D. O. Hodge, K. L. Kunze, M. R. Buras, M. N. Vogt, V. Herasevich, J. J. Dennis, R. J. Regimbal, P. R. Bauer, J. E. Blair, C. M. vanBuskirk, J. L. Winters, J. R. Stubbs, N. S. Paneth, N. C. Verdun, P. Marks, A. Casadevall, Early safety indicators of COVID-19 convalescent plasma in 5,000 patients. J Clin Invest, (2020 DOI: https://doi.org/10.1172/JCI140200
S. J. Zost, P. Gilchuk, J. B. Case, E. Binshtein, R. E. Chen, J. X. Reidy, A. Trivette, R. S. Nargi, R. E. Sutton, N. Suryadevara, L. E. Williamson, E. C. Chen, T. Jones, S. Day, L. Myers, A. O. Hassan, N. M. Kafai, E. S. Winkler, J. M. Fox, J. J. Steinhardt, K. Ren, Y. M. Loo, N. L. Kallewaard, D. R. Martinez, A. Schafer, L. E. Gralinski, R. S. Baric, L. B. Thackray, M. S. Diamond, R. H. Carnahan, J. E. Crowe, Potently neutralizing human antibodies that block SARS-CoV-2 receptor binding and protect animals. bioRxiv, (2020). DOI: https://doi.org/10.1101/2020.05.22.111005
Ashimiyu B. Durojaiye, John-Ross D. Clarke, George A. Stamatiades & Can Wang (2020): Repurposing cefuroxime for treatment of COVID-19: a scoping review of in silico studies, Journal of Biomolecular Structure and Dynamics, DOI: 10.1080/07391102.2020.1777904 DOI: https://doi.org/10.1080/07391102.2020.1777904
E. P. Scully, J. Haverfield, R. L. Ursin, C. Tannenbaum, S. L. Klein, Considering how biological sex impacts immune responses and COVID-19 outcomes. Nat Rev Immunol, (2020). DOI: https://doi.org/10.1038/s41577-020-0348-8
K. L. Flanagan, A. L. Fink, M. Plebanski, S. L. Klein, Sex and Gender Differences in the Outcomes of Vaccination over the Life Course. Annu Rev Cell Dev Biol 33, 577-599 (2017. DOI: https://doi.org/10.1146/annurev-cellbio-100616-060718
Kernan KF and Carcillo JA. Hyperferritinemia and inflammation. Int Immunol.2017;29:401-409. DOI: https://doi.org/10.1093/intimm/dxx031
Sanaei Dashti A, Alizadeh S, Karimi A, Khalifeh M and Shoja SA. Diagnostic value oflactate, procalcitonin, ferritin, serum-C-reactive protein, and other biomarkers inbacterial and viral meningitis: A cross-sectional study. Medicine (Baltimore).2017;96:e7637. DOI: https://doi.org/10.1097/MD.0000000000007637
Kawamata R, Yokoyama K, Sato M, Goto M, Nozaki Y, Takagi T, Kumagai H and Yamagata T. Utility of serum ferritin and lactate dehydrogenase as surrogate markersfor steroid therapy for Mycoplasma pneumoniae pneumonia. J Infect Chemother. 2015;21:783-9. DOI: https://doi.org/10.1016/j.jiac.2015.07.009
Lalueza A, Ayuso B, Arrieta E, Trujillo H, Folgueira D, Cueto C, Serrano A, Laureiro J, Arevalo-Canas C, Castillo C, Diaz-Pedroche C, Lumbreras C and group I. Elevation of serum ferritin levels for predicting a poor outcome in hospitalized patients with influenza infection. Clin Microbiol Infect. 2020. DOI: https://doi.org/10.1016/j.cmi.2020.02.018
Yang W, Cao Q, Qin L, Wang X, Cheng Z, Pan A, et al. Clinical characteristics and imaging manifestations of the 2019 novel coronavirus disease (COVID-19): a multi-center study in Wenzhou city, Zhejiang, China. J Infect 2020;80:388–93. DOI: https://doi.org/10.1016/j.jinf.2020.02.016
Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. J Am Med Assoc 2020;323:1061–69. https://doi.org/10.1001/jama.2020. DOI: https://doi.org/10.1001/jama.2020.1585
Matsumoto H, Kasai T, Sato A, Ishiwata S, Yatsu S, Shitara J, et al. Association between C-reactive protein levels at hospital admission and long-term mortality in patients with acute decompensated heart failure. Heart Ves 2019;34:1961–8. DOI: https://doi.org/10.1007/s00380-019-01435-9
Wang L. C-reactive protein levels in the early stage of COVID-19. Med Mal Infect 2020; 50:332–4. https://doi.org/10.1016/j. DOI: https://doi.org/10.1016/j.medmal.2020.03.007
Tan C, Huang Y, Shi F, Tan K, MaQ, Chen Y, et al. C-reactive protein correlates with CT findings and predicts severe COVID-19 early. J Med Virol 2020. https://doi.org/10.1002/jmv.25871 DOI: https://doi.org/10.1002/jmv.25871
Feng G, Zheng KI, Yan QQ, Rios RS, Targher G, Byrne CD, et al. COVID-19 and liver dysfunction: current insights and emergent therapeutic strategies. J Clin Transl Hepatol. 2020;8(1):1–7. DOI: https://doi.org/10.14218/JCTH.2020.00018
Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020;382(18):1708–20. DOI: https://doi.org/10.1056/NEJMoa2002032
Abbaspour N, Hurrell R, Kelishadi R. Review on iron and its importance for human health. Research J Med Sci. 2014;19(2):164–74.
Fleming DJ, Tucker KL, Jacques PF, Dallal GE, Wilson PWF, Wood RJ. Dietary factors associated with the risk of high iron stores in the elderly Framingham Heart Study cohort. Am J Clin Nutr. 2002;76:1375–84. DOI: https://doi.org/10.1093/ajcn/76.6.1375
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 Kais Khudair, Maysoon khudair AL-Hadraawy
This work is licensed under a Creative Commons Attribution 4.0 International License.
which allows users to copy, create extracts, abstracts, and new works from the Article, alter and revise the Article, and make commercial use of the Article (including reuse and/or resale of the Article by commercial entities), provided the user gives appropriate credit (with a link to the formal publication through the relevant DOI), provides a link to the license, indicates if changes were made and the licensor is not represented as endorsing the use made of the work.