Study The Effects Of Chronic Kidney Disease On The Level Of Thyroid Hormones In Iraqi Patients

Authors

  • Ezzate H. Ajeena Department of Biology, College of Science, University of Kufa, Iraq
  • Shaymaa H. Jabber Department of Biology, College of Science, University of Kufa,Iraq
  • Kalil Z.Kalil Veterinary College, University of Kufa, Iraq

DOI:

https://doi.org/10.36320/ajb/v12.i1.8152

Keywords:

chronic kidney disease , Thyroid hormones, blood pressure

Abstract

Chronic kidney disease is consider to be a major health issue which affecting high percent of population worldwide. This study attempted to determine the effects of chronic kidney disease on the function of thyroid gland by measuring its hormones levels . There were 70 subjects included in this study their age between 20 to 70 years divided into two groups, patients and control groups each one contain 35 persons. Blood was obtained from the all subjects for measuring the levels of thyroid hormones . There was increasing in the incidence of chronic kidney disease in the fifties of age as the results of this study revealed. The levels of thyroid hormones recorded significantly P≤0.05 decreasing in patients with chronic kidney disease when compared with healthy persons. For conclude, chronic kidney disease leads to significant changes in the levels of thyroid hormones that need to be carefully interpreted in these patients.

Downloads

Download data is not yet available.

References

Couser, W. G., Remuzzi, G., Mendis, S., & Tonelli, M. (2011). The contribution of chronic kidney disease to the global burden of major noncommunicable diseases. Kidney international, 80(12), 1258-1270. DOI: https://doi.org/10.1038/ki.2011.368

‏Lozano, R., Naghavi, M., Foreman, K., Lim, S., Shibuya, K., Aboyans, V., ... & AlMazroa, M. A. (2012). Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. The lancet, 380(9859), 2095-2128.‏

Wang, H., Naghavi, M., Allen, C., Barber, R. M., Bhutta, Z. A., Carter, A., ... & Coggeshall, M. (2016). Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015. The lancet, 388(10053), 1459-1544.‏ DOI: https://doi.org/10.1016/S0140-6736(16)31012-1

Kaptein EM.(1986) Thyroid function in renal failure. Contributions to Nephrology .50 64–72. DOI: https://doi.org/10.1159/000412989

Pham, H., Robinson-Cohen, C., Biggs, M. L., Ix, J. H., Mukamal, K. J., Fried, L. F., ... & de Boer, I. H. (2012). Chronic kidney disease, insulin resistance, and incident diabetes in older adults. Clinical Journal of the American Society of Nephrology, 7(4), 588-594.‏ DOI: https://doi.org/10.2215/CJN.11861111

Yen, P. M. (2001). Physiological and molecular basis of thyroid hormone action. Physiological reviews, 81(3), 1097-1142.‏ DOI: https://doi.org/10.1152/physrev.2001.81.3.1097

Iglesias, P., & Diez, J. J. (2009). Thyroid dysfunction and kidney disease. European journal of endocrinology, 160(4), 503-515.‏ DOI: https://doi.org/10.1530/EJE-08-0837

Singh, P. A., Bobby, Z., Selvaraj, N., & Vinayagamoorthi, R. (2006). An evaluation of thyroid hormone status and oxidative stress in undialyzed chronic renal failure patients. Indian journal of physiology and pharmacology, 50(3), 279.‏

G. Chinnapu Reddy, Ramakrishna Devaki, Pragna Rao.(2013). iron indices in patients with functional anemia in chronic kidney disease. The Journal of the International Federation of Clinical Chemistry and Laboratory Medicine .vol.24, no.3-4

Elisabeth Ejerblad, C. Michael Fored, Per Lindblad, Jon Fryzek, Paul W. Dickman, Carl-Gustaf Elinder, Joseph K. Mclaughlin, and Olof Nyre´N. (2004). association between smoking and chronic renal failure in a nationwide population-based case-control study. J Am Soc Nephrol 15: 2178–2185 DOI: https://doi.org/10.1097/01.ASN.0000135048.35659.10

Rule AD, Amer H, Cornell LD et al.( 2010). The association between age and nephrosclerosis on renal biopsy among healthy adults. Ann Intern Med; 152: 561–567. DOI: https://doi.org/10.7326/0003-4819-152-9-201005040-00006

Epstein M.(1996). Aging and the Kidney. J Am Soc Nephrol;7:1106-1122. DOI: https://doi.org/10.1681/ASN.V781106

Nyengaard JR, Bendtsen TF.(1992). Glomerular number and size in relation to age, kidney weight, and body surface in normal man. Anat Rec;232:194-201. DOI: https://doi.org/10.1002/ar.1092320205

Ibrahim Abdelmajeed Ginawi, Hussain Gadelkarim Ahmed, Awdah M. Al-hazimi.(2014). Assessment of Risk Factors for Chronic Kidney Disease in Saudi Arabia. International Journal of Science and Research, Volume 3 Issue 7.

United States Renal Data System. 2015 USRDS annual data report: Epidemiology of kidney disease in the United States. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases.

Nuyts GD, Van Vlem E, Thys J, De Leersnijder D, D’Haese PC, Elseviers MM, De Broe ME. (1995). New occupational risk factors for chronic renal failure. Lancet 346: 7–11, DOI: https://doi.org/10.1016/S0140-6736(95)92648-8

Stengel B, Couchoud C, Cenee S, Hemon D. (2000). Age, blood pressure and smoking effects on chronic renal failure in primary glomerular nephropathies. Kidney Int 57: 2519–2526, DOI: https://doi.org/10.1016/S0085-2538(15)47011-5

Iseki K, Ikemiya Y, Fukiyama K. (1996). Blood pressure and risk of end-stage renal disease in a screened cohort. Kidney Int Suppl 55: S69–S71,

Guyton AC, Coleman TG, Wilcox CS.(1999). Quantitative analysis of the pathophysiology of hypertension. J Am Soc Nephrol; 10: 2248–2249.

Hanratty R, Chonchol M, Miriam Dickinson L, Beaty BL, Estacio RO, Mackenzie TD, Hurley LP, Linas SL, Steiner JF, Havranek EP.(2010). Incident chronic kidney disease and the rate of kidney function decline in individuals with hypertension. Nephrol Dial Transplant, 25(3):801-807. DOI: https://doi.org/10.1093/ndt/gfp534

J. Horáček1, S. Dusilová Sulková, M. Kubišová, R. Šafránek, E. Malířová, M. Kalousová, I. Svilias1, J. Malý, L. Sobotka, P. Žák. (2012). Thyroid Hormone Abnormalities in Hemodialyzed Patients: Low Triiodothyronine As Well As High Reverse Triiodothyronine Are Associated With Increased Mortality. Physiol. Res. 61: 495-501, DOI: https://doi.org/10.33549/physiolres.932321

Carrero Jj, Qureshi Ar, Axelsson J, Yilmaz Mi, Rehnmark S, Witt Mr, Bárány P,

Heimbürger O, Suliman Me, Alvestrand A, Lindholm B, Stenvinkel P.( 2007). Clinical and biochemical implications of low thyroid hormone levels (total and free forms) in euthyroid patients with chronic kidney disease. J Intern Med 262: 690-701, DOI: https://doi.org/10.1111/j.1365-2796.2007.01865.x

Balaji Rajagopalan, Pragna B. Dolia, Veerendra Kumar Arumalla and

Seshadri Reddy V.(2013). Renal function markers and thyroid hormone status in undialyzed chronic kidney disease. Al Ameen J Med Sci; 6(1) :70-74

Lo JC, Chertow GM, Go AS, Hsu CY.(2005). Increased prevalence of subclinical and clinical hypothyroidism in persons with chronic kidney disease. Kidney International; 67: 1047–1052. DOI: https://doi.org/10.1111/j.1523-1755.2005.00169.x

Lim VS.(2001). Thyroid function in patients with chronic renal failure. American Journal of Kidney Diseases ; 38: S80–S84. DOI: https://doi.org/10.1053/ajkd.2001.27410

Dudani RA, Desai KB, Mehta MN, Mani LS, ACharya VN.(1981). Thyroid dysfunction in uremia. J Assoc Phys India; 29: 1038–1040.

Singh PA, Bobby Z, Selvaraj N, Vinayagamoorthi R.(2006). An evaluation of thyroid hormone status and oxidative stress in undialyzed chronic renal failure patients. Indian Journal of Physiology and Pharmacology; 50: 279–284.

G. Basu and A. Mohapatra. (2012). “Interactions between thyroid disorders and kidney disease,” Indian Journal of Endocrinology and Metabolism, vol. 16, no. 2, pp. 204–213, DOI: https://doi.org/10.4103/2230-8210.93737

Downloads

Published

2020-03-22

How to Cite

H. Ajeena, E., H. Jabber, S., & Z.Kalil, K. (2020). Study The Effects Of Chronic Kidney Disease On The Level Of Thyroid Hormones In Iraqi Patients. Al-Kufa University Journal for Biology, 12(1), 1–8. https://doi.org/10.36320/ajb/v12.i1.8152

Similar Articles

1 2 3 4 5 6 7 8 9 10 > >> 

You may also start an advanced similarity search for this article.