Evaluation the concentration of interferon- gamma and, GM-CSF in patients with tonsillitis

Authors

  • Abbas Sabbar Dahkil Al-naely

DOI:

https://doi.org/10.36320/ajb/v8.i2.9261

Keywords:

interferon- gamma, GM-CSF, tonsillitis

Abstract

This study was conducted on 90 subjects whom have visited the AL-Sadder Medical City and Al-Hakeem hospital in AL- Najaf governorate between the period extended from February to August, 2013. Subjects of this study were seventy chronic or recurrent tonsillitis patients, their age ranged from: 4-33 years and comprised of 29 males and 41 females.. In addition, 20 (age-and sex-matched) healthy adults without any evidence of chronic inflammatory disease depended as the control group.

        Five milliliters of blood sample collected from each patient , for the purpose of obtaining a serum sample and measured the concentration of cytokines using ELISA technique .
Results showed a significant increase to the high concentration of cytokines : interferon - gamma , colony stimulating factor granule cells and mononuclear , in all the groups of patients compared with those of healthy control group

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References

- Hutt-Fletcher, L. M. (2007). EBV entry. J Virol; 81(15): 7825-32. DOI: https://doi.org/10.1128/JVI.00445-07

- Tolley, N.; Georgalas, C.; Narula, N. and BMJ. (2007). Clinical Evidence June. Tonsillectomy. Cold steel tonsillectomy compared with diathermy tonsillectomy.

- Thomsen, A.; Nansen, A.; Madsen, A.; Bartholdy, C. and Christensen, J. (2003). Regulation of T cell migration during viral infection: role of adhesion molecules and chemokines. Immunol Letters 85:119-127. DOI: https://doi.org/10.1016/S0165-2478(02)00236-5

- Emoine, R.; Velge-Roussel, F. and Herr, F. (2010). “Interferon gamma licensing of human dendritic cells in T-helperindependent CD8+ alloimmunity,” Blood, vol. 116, no. 16, pp. 3089–3098. DOI: https://doi.org/10.1182/blood-2010-02-268623

- Mubeccel, A.; Deniz, G.; Erten, G.; Kücüksezer, U. C.; Kocacik, D.; Karagiannidis, C.; Aktas, E. and Akdis, C. A. (2011). Regulatory NK cells suppress antigen-specific T cell responses. J. Immunol. 15: 180-850. DOI: https://doi.org/10.4049/jimmunol.180.2.850

- Enzler, T.; Gillessen, S. and Manis, J. P. (2003). Deficiencies of GM-CSF and interferon gamma link inflammation and cancer. J. Exp. Med., 197, 213-9. DOI: https://doi.org/10.1084/jem.20021258

- Lien, J. M.; Li, B. and Rimmer, E. (2001). Enhancement of the antitumor efficacy of a GM-CSF-secreting tumor cell immunotherapy in preclinical models by cytosine arabinoside. Exp. Hematol.; 36: 319-28. DOI: https://doi.org/10.1016/j.exphem.2007.11.005

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Published

2016-04-23

How to Cite

Sabbar Dahkil Al-naely, A. (2016). Evaluation the concentration of interferon- gamma and, GM-CSF in patients with tonsillitis. Al-Kufa University Journal for Biology, 8(2), 131–140. https://doi.org/10.36320/ajb/v8.i2.9261