Effect of grading of varicocele on sperm parameters, oxidative stress and Chromatin maturityand inhibin B levels of infertile patients with varicocele
DOI:
https://doi.org/10.36320/ajb/v8.i3.9296Keywords:
Varicocele, grading of Varicocele, seminal fluid,MDA, ROS, GSH,SOD1,CAT, Inhibin B,chromatin maturitypercent.Abstract
The current study included 78 infertile patients complaining from varicocele with three different grading (garde1:n=42, grade2:n=23, grade3:n=13)who attended to fertility Center in Al-Sadr Medical City in Al-Najaf Health Directorate/Ministry of Health/Iraq.This study aimed to determine the effect of grading of varicocele on sperm parameters and the levels of MDA (Malondialdehyde), ROS (Reactive oxygen species), GSH (Glutathione), SOD1 (superoxide dismutase1), CAT (Catalase) in semen, Inhibin B concentration in semen and serum alsosperm chromatin maturity percent in seminal fluidof infertile patients with varicocele.
The result showed the sperm parameters quality, GSH,SOD1,CAT, Inhibin B levels and sperm chromatin maturity percent in infertile with varicocele grade 3 were significant decreased(P <0.05) compared to infertile with varicocele grade 2, also the MDA and ROS concentration revealed significant increase in the same comparison.It was concluded:the severity of varicocele can lead to a significant harmful effect on sperm parameters,oxidative stress, chromatin maturity percent and level of inhibin B in serum and seminal plasma of infertile male who complaining of varicocele.
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Copyright (c) 2017 Ali Jehad N. Al-Huwaizi, FarisNaji A. Al-Hady, Sahib Y. Al- Murshedi
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