Estimation Levels of Osteoponetin, Glutathione Peroxidase and Vitamin D3 in Type Π Diabetic Patients with Renal Failure Undergoing Hemodialysis

Abstract

Backgrounds: Twenty to twenty five percentage of T2DM patients eventually develop nephropathy depending on genetic predisposition. It is the cause of death of 17% of these patients. The exact mechanisms which cause diabetic nephropathy are unknown, although probably multifactorial, the cause of nephropathy may be due to the accumulation of a reduced sugar product (sorbitol) or a tissue toxin that can affect the Na-K-ATP pump. However, in T2DM, mesangiallymphokine production is associated not only with hyperglycemia but also with insulin resistance and generalized vascular disease, thus albuminuria may occur even before hyperglycemia develops. Subjects: The current study included 88 people who were divided into two groups: the first included 50 patients suffering from kidney failure (18 females and 32 males), their ages range between (36-78 years) and they are subject to dialysis, while the second group included 38 individuals (11 females and 27 males) their ages range between (31-64 years), as a control group. Aim of The Study: The current study is designed to find out the levels of Osteoponetin, Glutathione Peroxidase, 1,25 Di hydroxyl vitamin D3 in the sera of study individuals. Conclusions: Kidney complications of type Π diabetes can develop in the patients regardless their gender or age. Osteoponetin is an excellent diagnostic tool for diagnosing kidney failure caused by the complications of diabetes and for predicting the kidney's efficiency to perform its vital functions. The capacity of cellular defense enzymes diminishes with increasing cellular oxidative stress as the renal damage from complications of type Π diabetes reaches the stage of renal failure requiring dialysis. Vitamin D levels are considered low among the people studied, whether they are diabetics undergoing dialysis or in good health.