Evaluation of Vit. D3 and Zn levels in patients with urinary tract infections

Abstract

Background: Vitamin D, known for its immunoregulatory effects and antimicrobial properties, plays a crucial role in regulating inflammation and chemokine production. Zinc is influential for a healthy immune system and human health, influencing cell differentiation, proliferation, and apoptosis, which impact organism growth.

Objective: Determine the serum zinc and vitamin D₃ levels in UTI patients and controls to detect the role of vit. D₃ and Zn in UTIs, and their levels in recurrent and non-recurrent infections.

Materials and Methods: Samples of 60 urinary tract infection patients, distributed between 30 females and 30 males, were collected from Imam Hassan Al-Mujtaba Hospital for the period from December 2022 to April 2023. After collecting venous blood samples from patients and the controls, the serum was separated to measure the concentrations of vitamin D₃ and zinc. The concentration of vitamin D₃ was measured using the Cobas system, while the concentration of zinc was measured using a Mindray device.

Results: UTI patients have lower serum zinc levels than the controls group, with the patient group having 83.0 mg/dL compared to the control group. Vitamin D₃ was also low in the patients group compared to controls (10.50, 12.58 respectively).

Conclusion: Vitamin D₃ and zinc levels can influence UTI development, with patients having lower serum vit. D₃ and zinc than the controls group, indicating a potential risk of UTI.