Evaluation of lipid peroxidation, lipid profile and antioxidant status in patients with non-insulin dependent diabetes mellitus in Najaf / Iraq.

Abstract

Background: Diabetes mellitus arises when insufficient insulin is produced, or when the available insulin does not function correctly. Without insulin, the amount of glucose in the blood stream is abnormally high, causing unquenchable thirst and frequent urination. The body's inability to store or use glucose causes hunger and weight loss. Type 2 diabetes' occurs when there is a severe lack of insulin due to the destruction of most or all of the beta ((ß – cells) in the islets of Langerhans. Diabetes mellitus is considered to be one of a rank of free radical diseases which propagates complications with increased free radical formation. Oxidative stress is increased in diabetes mellitus owing to the increase in the production of oxygen free radicals and a deficiency in antioxidant defense mechanisms. Lipid peroxidation of cellular structures, a consequence of increased oxygen free radicals, is thought to play an important role in atherosclerosis and microvascular complications of diabetes mellitus. Hyperlipidemia has also been reported as one of the causative factors for increased lipid peroxidation in diabetes mellitus. The study was designed to find out the relationship between lipid peroxidation, and complication of diabetes mellitus and to estimate the mutual relationship between serum lipoproteins levels and diabetes severity.