Evaluation of Vascular Endothelial Growth Factor-A (VEGF A) in Iraqi patients with urinary bladder cancer

Abstract

Objective: The aim of this work is to study the alterations in the vascular endothelial growth factor (VEGF-A), and its role in pathogenicity of bladder cancer in serum of men who are initially diagnosed with this disease.

Methodology: The current study was applied in pathology department of British United Kingdom kings college hospital during April 2012 to August 2013 by using Enzyme Linked Immuno Assay (ELISA) on serum taken from 42 men infected with bladder cancer, and other 38 benign considered as a control group to detect vascular endothelial growth factor type A (VEGF-A). Data analysis: SPSS computerizing system has been used for statistically analysis of data.

Results: The results revealed a highly significant (P <1.15) level of VEGF-A in serum of patients in comparison with the control group.

Conclusion: It was concluded of the results of the present study that VEGF-A was good prognostic biomarker for urinary bladder cancer in men ,and these results significantly correlate with the early stages of disease.

Recommendation: It may be recommended that using VEGF-A to predict and diagnosis the bladder cancer.