Measurement of TPO Ab and TG Ab levels and its association with thyroid dysfunction in Graves’ disease patients in Najaf city
Keywords:GD, TPO Ab, TG Ab, TSH
Graves’ disease (GD) is a common autoimmune disease that accounts for the majority of cases of hyperthyroidism in the developed world (Rich & Fleisher, 2018) Autoimmune thyroid Graves' disease is one of the most common autoimmune disease (AID), affecting 13 million people and targeting women seven times as often as men. It most often affects young to middle-aged adults but can occur at all ages.(Vos et al., 2009). Aim of The study is determination of TPO Ab levels and TG Ab and its correlation with thyroid dysfunction in Graves’ disease patients. A Case - control study was done on 100 patients with GD diagnosed at three hospitals in Najaf city in Iraq, in Al-Sadr Teaching Hospital, Al-Hakim General Hospital, and Al-Najaf Teaching Hospitals, respectively, with group of 32 healthy individual as control. Blood sample was collected from all patients and control. TPO Ab and TG Ab levels were measured by enzyme-linked immunosorbent assay (ELISA). While TSH, T3 and T4 hormones measured by Cobas e 411 analyzer. The result shown that female (89%) more than male (11%), and the mean age (36.86) were highest than other age. This result explain that there was a high significant in TSH, T3 and T4. Also there was a high significant in TPO Ab and TG Ab in patient compared with control group.
Al-Gazally, M. E., Al-shalah, M. A., & Muttaleb, S. A. (2013). The Role of Thyrotropin Hormone Receptor Antibody (TRAb) in Distinguishing between Autoimmune and non-Autoimmune Disease. Med J Babylon, 10(1).
Ali, H., Altaf Baig, J., & Alam, J. M. (2017). Frequency distribution of anti-thyroid peroxidase and anti-thyroglobulin antibodies in relation to TSH, T3 and T4 levels. In Pakistan Physiological Society (Vol. 13, Issue 3).
Anvari, M., Khalilzadeh, O., Esteghamati, A., Momen-Heravi, F., Mahmoudi, M., Esfahani, S. A., Rashidi, A., & Amirzargar, A. (2010). Graves’ disease and gene polymorphism of TNF-α, IL-2, IL-6, IL-12, and IFN-γ. Endocrine, 37(2), 344–348. https://doi.org/10.1007/s12020-010-9311-y
Baldé, N. M., Kaké, A., Sylla, D., Diallo, M. M., Diango, A., Kourouma, L., ... & Barry, M. A. . (2022). Graves’ Disease in 100 Cases in Conakry: Epidemiological, Clinical, Therapeutic, and Evolutionary Aspects (pp. 12(2), 75-81.). Open Journal of Endocrine and Metabolic Diseases. https://doi.org/10.4236/ojemd.2022.122005 Feb.
Czarnocka, B., Eschler, D. C., Godlewska, M., & Tomer, Y. (2013). Thyroid Autoantibodies: Thyroid Peroxidase and Thyroglobulin Antibodies. In Autoantibodies: Third Edition (pp. 365–373). https://doi.org/10.1016/B978-0-444-56378-1.00044-7
Davies, T. F., Andersen, S., Latif, R., Nagayama, Y., Barbesino, G., Brito, M., Eckstein, A. K., Stagnaro-Green, A., & Kahaly, G. J. (2020). Graves’ disease. Nature Reviews Disease Primers, 6(1). https://doi.org/10.1038/s41572-020-0184-y
Elmugadam, A. A., Elobied, E. A., Mustafa, H. A., Elfadil, G. A., & Makeen, A. M. (2014). Anti-TPO and Anti-Tg antibodies in Sudanese patients with thyroid diseases and association of HLA class-II with Graves’ disease. Journal of American Science, 10(2), 39–42.
Holmberg, M. (2020). Outcome of Graves disease. https://gupea.ub.gu.se/handle/2077/62211
J. Larry Jameson, A. C. P. (2013). Harrison’s Endocrinology. In J. Larry Jameson (Ed.), Harrison’s Endocrinology (3rd ed., Vol. 53, Issue 9). McGraw-Hill Education, LLC. All rights reserved. https://doi.org/10.1017/CBO9781107415324.004
Liu, Z. W., Masterson, L., Fish, B., Jani, P., & Chatterjee, K. (2015). Thyroid surgery for Graves’ disease and Graves’ ophthalmopathy. Cochrane Database of Systematic Reviews, 2015(11). https://doi.org/10.1002/14651858.CD010576.pub2
Mohammed Ali, A. J., & Hamoud, M. J. M. (2022). Assessment of the Correlation Between Vitamin D and T3, T4, FT3, FT4 and TSH Among Patients with Graves’ Disease. Pakistan Journal of Medical and Health Sciences, 16(5), 1500–1502. https://doi.org/10.53350/pjmhs221651500
Morshed, S. A., Ma, R., Latif, R., & Davies, T. F. (2013). How one TSH receptor antibody induces thyrocyte proliferation while another induces apoptosis. In Journal of Autoimmunity (Vol. 47, pp. 17–24). https://doi.org/10.1016/j.jaut.2013.07.009
Nabi, M., Noor, R., Zahid, A., Zulfiqar, T., Khalid, A., & Ri, S. (2022). Grave’s Disease: Pathophysiology of a Model Autoimmune Disease. Archives of Microbiology & Immunology, 06(02), 149–164. https://doi.org/10.26502/ami.93650083
Prabhakar, B. S., Bahn, R. S., & Smith, T. J. (2003). Current Perspective on the Pathogenesis of Graves’ Disease and Ophthalmopathy. Endocrine Reviews, 24(6), 802–835. https://doi.org/10.1210/er.2002-0020
Rich, R. R., & Fleisher, T. A. (2018). Clinical Immunology (Fifth Edition) Principles and Practice. In Clinical Immunology.
Saeed, M. H., Kurosh, K., Zahra, A., Hossein, D. M., Davood, R., & Ataollahi, M. R. (2020). Decreased serum levels of il-27and il-35 in patients with graves disease. In Archives of Endocrinology and Metabolism (Vol. 64, Issue 5, pp. 521–527). https://doi.org/10.20945/2359-3997000000227
Shoenfeld, Y., Cervera, R., & Gershwin, M. E. (2008). Diagnostic Criteria in Autoimmune Diseases (S. M. C. Shoenfeld Yehuda (ed.)). Library of Congress Control Number: 2008933364. https://doi.org/10.1007/978-1-60327-285-8
Smith, T. J., & Hegedüs, L. (2016). Graves’ disease. American Practitioner and Digest of Treatment, 2(7), 488–493. https://doi.org/10.1056/nejmra1510030
Tomer, Y., & Huber, A. (2009). The etiology of autoimmune thyroid disease: A story of genes and environment. Journal of Autoimmunity, 32(3–4), 231–239. https://doi.org/10.1016/j.jaut.2009.02.007
Vos, X. G., Smit, N., Endert, E., Brosschot, J. F., Tijssen, J. G. P., & Wiersinga, W. M. (2009). Age and stress as determinants of the severity of hyperthyroidism caused by Grave’s disease in newly diagnosed patients. European Journal of Endocrinology, 160(2), 193–199. https://doi.org/10.1530/EJE-08-0573
Xu, J., Huang, G., Weng, L., Gong, L., Mao, Y., Li, Y., & Li, M. (2022). Low serum interleukin-38 levels in patients with Graves’ disease and Hashimoto’s thyroiditis. Journal of Clinical Laboratory Analysis, 36(1), 1–7. https://doi.org/10.1002/jcla.24101
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