Sperms cytotoxicity and testicular damage induced by Azithromycin drug and the protective role of garlic in male albino rats
Keywords:
Azithromycin, Garlic, testicular damage , testis , spermsAbstract
The objective of current study was to identify the adverse effect of Azithromycin drug and the protective role of garlic in cytotoxicity test included sperms deformation and histological changes in testes tissue of male albino rats.
The animal groups were administrated by Azithromycin and garlic orally for two weeks.
The study recorded significant p≥0.05 increase in sperms head and tail deformation rate in group was administrated Azithromycin compared with control group which was administrated distilled water, the results recorded high significant p≥0.05 increase in sperms head and tail deformation rate in group was administrated Azithromycin + garlic compared with control groups were administrated distilled water and garlic.
Furthermore, the results reported significant p≥0.05 decrease in sperms head and tail deformation rate in group was administrated Azithromycin + garlic compared with only Azithromycin administrated group.
Moreover, the study indicated histological changes in testes tissue included degenerative changes represented by depletion of the spermatogonial cells (some seminiferous tubules appeared with one or two layers of spermatogonia) in group was administrated Azithromycin compared with control groups which was administrated distilled water and garlic.
In addition, the study indicated slight histological changes in testes tissue compared with normal testes architecture, somniferous tubules with maturation of spermatogony and sperms inside the lumen in group were administrated Azithromycin +garlic compared with control groups which were administrated distilled water and garlic.
Finally, the findings showed reduction in histological changes of testes tissue in group which was administrated Azithromycin +garlic compared with group which was administrated Azithromycin only.
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