Study of Activin A and Inhibin A Hormones levels in Polycystic Ovarian Syndrome and their Correlation with Other Biochemical Parameters

Abstract

Polycystic ovary syndrome (PCOS) is very common endocrinological disorder in premenapusal women.  Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle. Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis (8)metabolism, homeostasis, immune response, wound repair and  endocrinefunction.  Activin and Inhibin  are produced in the gonads, pituitary gland, placenta, and other organs.

The results of the present study showed that serum Inhibin A    level is low in PCOS, while no difference in the level of serum Activin A in PCOS patients in comparing with control group. The results of the present study showed that serum Inhibin A was negatively correlated with age,and Directly correlated with serum Testosterone and E2. Activin A level in PCOS women showed a significant Positive correlation with LH and LH/FSH ratio