STUDY THE CLINICAL RELATIONSHIP BETWEEN CHRONIC HEPATITIS B AND SERUM TRACE ELEMENT LEVELS

Abstract

In the present study serum trace element including Cupper (Cu), Iron (Fe) ,and Zinc (Zn) ,where determine by using atomic absorption in sera of patient with viral hepatitis (B)cases (n=40) and statistically compared with controls (n=20). The results showed that , in viral hepatitis Cu level where found as 1.5+/-0.29 ppm and this value was significantly higher than in control group1.0+/- 0.15 ppm (p<0.05), Zn level found to be significantly low in viral hepatitis patients0.56+/-0.09 ppm where in healthy individual was 0.87+/-0.07 ppm (p<0.05) . There is no significantly difference between hepatitis patients and controls in serum Fe level (1.21+/-0.2, 1.27+/-0.34) ppm (p<0.05) respectively.. It was indicated that absorption disorders in gastrointestinal system, especially in chronic cases, were not main causes of decrease of trace elements by iron and several other parameters in sera of the cases. Therefore, it is suggested that the decrease in Zn level and elevation in Cu levels are probably resulted from defense strategies of organism and induced by the hormone-like substances.