SYNTHESIS AND CHARACTERIZATION OF SOME METAL COMPLEXES WITH SOME FURANOSE RINGS AND STUDY THEIR BIOLOGICAL ACTIVITY

Abstract

1,2:5,6-Di-O-isopropylidene (2) as starting material have been synthesized by the reaction of D-glucose with dry acetone in presence of Zncl₂/H₃Po₃.3-ullos derived (3) was prepared by oxidation of (2) with DMSO/Ac₂O. Hydrolysis of (2) and (3) by 60% Ac₂O gave the corresponding derivateivies 1,2-O- isopropytidene –α – D -glucofuranose (L₁) and 1,2-isoproplyene-α-D-ribohexafuranose-3-ulos(LΠ). Coordination chemistry of L₁and LΠ with Co(Π), Cu(Π), Ni(Π), Pd(Π) and Pt(ІV) ions were studied. The two ligands were characterized depending upon CHN analyses, Ή NMR and FTIR. Structure of metal complexes were proposed depending on atomic absorption, CHN, Thermal analyses (TG & DTG), FTIR spectra, uv-vis and chloride contents, magnetic moments (meft) as well as conductivity measurements. From the spectral measurements, monomer structures for the complexes were proposed. The newly metal complexes were subjected to in vitro testing agains pathogenic microorganisms