Iron Status in Patients with Primary Hypertension

Abstract

Hypertension is a major health problem in adults, and contributesto cardiovascular disease. Iron represents a paradox for human health by being essential for many important biological process, but also having an ability to be harmful in many different. In the present study, an attempt is carried out to define the iron status in Iraqi hypertensive patients. The aim is to obtain a recommendation about the risk of increased iron indices as a marker for subsequent ischaemic heart diseases.

Eighty-eight hypertensive uncomplicated, hypertensive patient, but otherwise have no other systemic diseases patients aged 49±13 years old, were entered into the study. Serum levels of iron,, total Iron Binding Capacity (TIBC), and ferritin were measured while Unsaturated iron-binding capacity (UIBC), estimated total iron body stores (ETIBS), transferrrin saturation percentage (TS%) and transferrin concentration were calculated mathematically.

        The results showed a significant difference (p<0.05) in all iron indices of hypertensive patients in comparing with healthy control group except TIBC, UIBC, and transferrin concentrations, which decrease in these patients in comparing with control group. There is a significant increase in serum ferritin and EIBS in male group as compared with female group. While all other iron indices were differ insignificantly between groups.It can be concluded that hypertensive patients have significantly higher level of iron parameters than control group. There is no significant difference between male and female groups in most iron indices except in ferritin and subsequently EIBS levels. Further studies required for other biochemical parameters in larger patients sample size.

Keywords: Iron, TIBC, Ferritin,  and Hypertension