Insulin Resistance, Lipid Profile, C-Peptide, and Their Interplay in Type 2 Diabetes: A Basrah Population Study

Authors

  • Shurok Namah College of Health and Medical Techniques - Baghdad, Middle Technical University, Baghdad, Iraq
  • prof Dr. College of Health and Medical Techniques - Baghdad, Middle Technical University, Baghdad, Iraq
  • Assist prof College of Health and Medical Techniques - Baghdad, Middle Technical University, Baghdad, Iraq

DOI:

https://doi.org/10.36320/ajb/v16.i3.15673

Keywords:

Type 2 diabetes mellitus, C-peptide, insulin, HBA1C, Lipide profile

Abstract

Diabetes Mellitus (DM) is One of recognized metabolic disorder that can be distinguish by its chronic character, abnormalities in metabolism of proteins, lipids, carbohydrates, and hyperglycemia. Due to its extensive prevalence roughly one in ten people worldwide it's crucial to recognize and treat this illness. The revised goal is Investigating the complex interactions between insulin and insulin resistance is goal of this study.; (IR), lipid profiles, and C-peptide and their levels in the Basrah, Iraq, population with Diabetes Type 2 (T2DM). Furthermore, we aim to discuss the clinical significance of these findings and their implications for T2DM management in this region. In our investigation, significant differences (p < 0.001) were observed in parameters like Insulin and C-Peptide between T2DM patients and the control group. Other parameters like HbA1C%, FBG, Cholesterol, Triglyceride, HDL, and LDL showed varying significance levels, with p-values ranging from 0.001 to 0.002. Our study highlighted substantial distinctions between individuals with T2DM and healthy control group across multiple critical parameters. These differences, I mean elevated C-peptide, insulin, HbA1C, FBG, cholesterol, triglyceride, and LDL levels in T2DM patients suggest the potential influence of these markers on severity of condition

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References

I. González-Mariscal, S. M. Krzysik-Walker, M. E. Doyle, Q. R. Liu, R. Cimbro, S. Santa-Cruz Calvo, and J. M. Egan, “Human CB1 receptor isoforms, present in hepatocytes and β-cells, are involved in regulating metabolism,” Scientific Reports, vol. 6, no. 1, 33302, 2016, https://doi.org/10.1038/srep33302

A. Katsarou, S. Gudbjörnsdottir, A. Rawshani, D. Dabelea, E. Bonifacio, B. J. Anderson, and Å. Lernmark, “Type 1 diabetes mellitus,” Nature Reviews Disease Primers, vol. 3, no. 1, pp. 1-17, 2017, https://doi.org/10.1038/nrdp.2017.16

F. K. Malerbi, R. E. Andrade, P. H. Morales, J. A. Stuchi, D. Lencione, J. V. de Paulo, and R. Belfort Jr, “Diabetic retinopathy screening using artificial intelligence and handheld smartphone-based retinal camera,” Journal of Diabetes Science and Technology, vol. 16, no. 3, pp. 716-723, 2022, https://doi.org/10.1177/1932296820985567

L. Blonde, G. E. Umpierrez, S. S. Reddy, J. B. McGill, S. L. Berga, M. Bush, and S. L. Weber, “American Association of Clinical Endocrinology clinical practice guideline: developing a diabetes mellitus comprehensive care plan—2022 update,” Endocrine Practice, vol. 28, no. 10, pp. 923-1049, 2022, https://doi.org/10.1016/j.eprac.2022.08.002

M. J. Haller, S. A. Long, J. L. Blanchfield, D. A. Schatz, J. S. Skyler, J. P. Krischer, and C. J. Greenbaum, “Low-dose anti-thymocyte globulin preserves C-peptide, reduces HbA1c, and increases regulatory to conventional T-cell ratios in new-onset type 1 diabetes: two-year clinical trial data,” Diabetes, vol. 68, no. 6, pp. 1267-1276, 2019, https://doi.org/10.2337/db19-0057

E. Brindise, I. Elkhatib, A. Kuruvilla, and R. Silva, “Temporal trends in incidence and outcomes of acute pancreatitis in hospitalized patients in the United States from 2002 to 2013,” Pancreas, vol. 48, no. 2, pp. 169-175, 2019, https://doi.org/10.1097/MPA.0000000000001228

A. Shamsi-Goushki, Z. Mortazavi, M. A. Mirshekar, M. Mohammadi, N. Moradi-Kor, S. Jafari-Maskouni, and M. Shahraki, “Comparative effects of curcumin versus nano-curcumin on insulin resistance, serum levels of apelin and lipid profile in type 2 diabetic rats,” Diabetes, Metabolic Syndrome and Obesity, pp. 2337-2346, 2020, https://doi.org/10.2147/DMSO.S247351

I. I. Dedov, M. V. Shestakova, and G. R. Galstyan, “The prevalence of type 2 diabetes mellitus in the adult population of Russia (NATION study),” Diabetes mellitus, vol. 19, no. 2, pp. 104-112, 2016, https://doi.org/10.14341/DM2004116-17

H. Nakamura, H. Jinzu, K. Nagao, Y. Noguchi, N. Shimba, H. Miyano, and K. Iseki, “Plasma amino acid profiles are associated with insulin, C-peptide, and adiponectin levels in type 2 diabetic patients,” Nutrition & diabetes, vol. 4, no. 9, e133-e133, 2014, https://doi.org/10.1038/nutd.2014.32

A. H. Zargar, A. K. Khan, S. R. Masoodi, B. A. Laway, A. I. Wani, M. I. Bashir, and F. A. Dar, “Prevalence of type 2 diabetes mellitus and impaired glucose tolerance in the Kashmir Valley of the Indian subcontinent,” Diabetes research and clinical practice, vol. 47, no. 2, pp. 135-146, 2000, https://doi.org/10.1016/S0168-8227(99)00110-2

J. C. Ozougwu, K. C. Obimba, C. D. Belonwu, and C. B. Unakalamba, “The pathogenesis and pathophysiology of type 1 and type 2 diabetes mellitus,” J Physiol Pathophysiol, vol. 4, no. 4, pp. 46-57, 2013, https://doi.org/10.5897/JPAP2013.0001

S. Bajaj, “RSSDI clinical practice recommendations for the management of type 2 diabetes mellitus 2017,” International journal of diabetes in developing countries, vol. 38, pp. 1-115, 2018, https://doi.org/10.1007/s13410-018-0604-7

H. Li, W. Lu, A. Wang, H. Jiang, and J. Lyu, “Changing epidemiology of chronic kidney disease as a result of type 2 diabetes mellitus from 1990 to 2017: estimates from Global Burden of Disease 2017,” Journal of diabetes investigation, vol. 12, no. 3, pp. 346-356, 2021, https://doi.org/10.1111/jdi.13355

H. Akimoto, A. Negishi, S. Oshima, H. Wakiyama, M. Okita, N. Horii, and D. Kobayashi, “Antidiabetic drugs for the risk of Alzheimer disease in patients with type 2 DM using FAERS,” American Journal of Alzheimer’s Disease & Other Dementias®, vol. 35, 1533317519899546, 2020, https://doi.org/10.1177/1533317519899546

A. M. Tourkmani, T. J. ALHarbi, A. M. B. Rsheed, A. A. Alrasheedy, W. ALMadani, F. ALJuraisi, and A. A. I. Alshaikh, “The impact of telemedicine on patients with uncontrolled type 2 diabetes mellitus during the COVID-19 pandemic in Saudi Arabia: findings and implications,” Journal of Telemedicine and Telecare, vol. 29, no. 5, pp. 390-398, 2023, https://doi.org/10.1177/1357633X20985763

H. Ş. Aktaş, Y. E. Uzun, O. Kutlu, H. H. Pençe, F. Özçelik, E. Ö. Çil, and T. Tükek, “The effects of high intensity-interval training on vaspin, adiponectin and leptin levels in women with polycystic ovary syndrome,” Archives of physiology and biochemistry, vol. 128, no. 1, pp. 37-42, 2022, https://doi.org/10.1080/13813455.2019.1662450

N. Mittman, B. Desiraju, I. Fazil, H. Kapupara, J. Chattopadhyay, C. M. Jani, and M. M. Avram, “Serum fructosamine versus glycosylated hemoglobin as an index of glycemic control, hospitalization, and infection in diabetic hemodialysis patients,” Kidney international, vol. 78, pp. S41-S45, 2010, https://doi.org/10.1038/ki.2010.193

A. A. Mahmoud, W. I. Jassim, A. A. H. Mohsin, and A. M. Senan, “Concentration of Asprosin Associated with Poor Control of Type 2 Diabetes Mellitus in Diyala Province,” Journal of Techniques, vol. 5, no. 2, pp. 123-128, 2023, https://doi.org/10.51173/jt.v5i2.932

Safa Nadhum Mohammed, Walaa Esmael Jassim, and Najah Ali Mohammed, “To Investigate the Associations of Dyslipidemia and BMI, as Risk Factors Leading to Insulin Resistance and Development of Type2 Diabetes Mellitus in Baqubah City”, JT, vol. 4, no. 3, pp. 27–33, Sep. 2022, https://doi.org/10.51173/jt.v4i3.538

S. A. Palma-Duran, A. Vlassopoulos, M. Lean, L. Govan, and E. Combet, “Nutritional intervention and impact of polyphenol on glycohemoglobin (HbA1c) in non-diabetic and type 2 diabetic subjects: Systematic review and meta-analysis,” Critical reviews in food science and nutrition, vol. 57, no. 5, pp. 975-986, 2017, https://doi.org/10.1080/10408398.2014.973932

S. Bellary, I. Kyrou, J. E. Brown, and C. J. Bailey, “Type 2 diabetes mellitus in older adults: clinical considerations and management,” Nature Reviews Endocrinology, vol. 17, no. 9, pp. 534-548, 2021, https://doi.org/10.1038/s41574-021-00512-2

E. C. Westman, “Type 2 diabetes mellitus: a pathophysiologic perspective,” Frontiers in nutrition, vol. 8, 707371, 2021, https://doi.org/10.3389/fnut.2021.707371

American Diabetes Association Professional Practice Committee, “8. Obesity and weight management for the prevention and treatment of type 2 diabetes: standards of medical care in diabetes—2022,” Diabetes Care, vol. 45, Supplement_1, pp. S113-S124, 2022, https://doi.org/10.2337/dc22-S008

N. A. ElSayed, G. Aleppo, V. R. Aroda, R. R. Bannuru, F. M. Brown, D. Bruemmer, and American Diabetes Association, “8. Obesity and weight management for the prevention and treatment of type 2 diabetes: standards of care in diabetes—2023,” Diabetes care, vol. 46, Supplement_1, pp. S128-S139, 2023, https://doi.org/10.2337/dc23-S008

N. Shah, M. A. Abdalla, H. Deshmukh, and T. Sathyapalan, “Therapeutics for type-2 diabetes mellitus: a glance at the recent inclusions and novel agents under development for use in clinical practice,” Therapeutic Advances in Endocrinology and Metabolism, vol. 12, 20420188211042145, 2021, https://doi.org/10.1177/20420188211042145

N. H. Hasrat and A. Q. Al-Yassen, “The Relationship Between Acne Vulgaris and Insulin Resistance,” Cureus, vol. 15, no. 1, 2023, https://doi.org/10.7759/cureus.34241

N. Sattar, A. Rawshani, S. Franzén, A. Rawshani, A. M. Svensson, A. Rosengren, and S. Gudbjörnsdottir, “Age at diagnosis of type 2 diabetes mellitus and associations with cardiovascular and mortality risks: findings from the Swedish National Diabetes Registry,” Circulation, vol. 139, no. 19, pp. 2228-2237, 2019, https://doi.org/10.1161/CIRCULATIONAHA.118.037885

A. Caturano, M. D’Angelo, A. Mormone, V. Russo, M. P. Mollica, T. Salvatore, and F. C. Sasso, “Oxidative stress in type 2 diabetes: impacts from pathogenesis to lifestyle modifications,” Current Issues in Molecular Biology, vol. 45, no. 8, pp. 6651-6666, 2023, https://doi.org/10.3390/cimb45080420

M. Michille, S. Situmorang, and W. Hanida, “RELATIONSHIP CHARACTERISTICS OF TYPE 2 DIABETES MELLITUS PATIENTS WITH LIPID PROFILE AT ROYAL PRIMA HOSPITAL IN 2021,” Jambura Journal of Health Sciences and Research, vol. 5, no. 1, pp. 42-50, 2023, https://doi.org/10.35971/jjhsr.v5i1.16828

M. F. Raheem, S. H. Ali, and L. G. Shareef, “Impact of serum levels of vitamin D on lipid profiles, glycemic indices, and insulin resistance in obese type 2 diabetes patients: An observational study,” F1000Research, vol. 11, 1002, 2022, https://doi.org/10.12688/f1000research.125191.1

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Published

2024-12-07

How to Cite

Namah, S., Esmael, W., & Abdul-Hussein , A. (2024). Insulin Resistance, Lipid Profile, C-Peptide, and Their Interplay in Type 2 Diabetes: A Basrah Population Study. Al-Kufa University Journal for Biology, 16(3), 27-34. https://doi.org/10.36320/ajb/v16.i3.15673

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