Evaluate Interleukin-15 in SLE patients and its association with hemolytic anemia
DOI:
https://doi.org/10.36320/ajb/v16.i2.16840Keywords:
SLE disease, IL-15, hemolytic anemia, cytokines disturbancesAbstract
Systemic Lupus Erythematosus (SLE) is a clearly heterogeneous autoimmunity disorder with an unknown etiology that largely affects several body regions. Interleukin-15 (IL-15) is a cytokine that plays a vital role in the immune regulation and has been related in the pathogenesis of SLE disease. Hemolytic anemia is one of the hematological features of SLE, where the immune system breaks erythrocytes (red blood cells), causing anemia. The aim of this research is to evaluate IL-15 in SLE patients and their correlation with hemolytic anemia to see if this can be used as a biomarker for hemolytic anemia in SLE patients. This study analyzed the demographic and clinical presentation of 200 cases with whole blood and serum from this disease. ELISA and qPCR were also used to measure the amount of IL-15 at the gene and serum of SLE disease association hemolytic anemia. The results showed that IL-15 contributes to the immune response in hemolytic anemia from SLE. The data demonstrated that the gene and serum concentration of IL-15 in SLE disease patients associated with hemolytic anemia were higher than non-hemolytic anemia. In conclusion, the level of serum IL-15 was confirmed to be significantly higher in SLE patients associated with hemolytic anemia, not only in SLE disease patients.
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