Immunological and Comparative Study of Serum HSP-70 Level and MicroRNA-21 Expression with Clinical Findings in Patients with Diabetic Nephropathy
DOI:
https://doi.org/10.36320/ajb/v17.i1.19255Keywords:
Diabetic Nephropathy, HSP-70, MicroRNA-21, Biomarkers, Renal StressAbstract
Diabetic nephropathy is an important cause of morbidity and mortality in all types of diabetes. MicroRNA-21 expression can be induced by hypoxic conditions such as kidney injury and regulated in kidney diseases and may be used as a diagnostic biomarker in kidney diseases. On the other hand, in most people with nephropathy, heat shock protein (HSP 70) has been investigated from different aspects in experimental studies. HSP-70 is the most abundant form of HSP in cells. HSP-70 is involved in the response to various acute and chronic conditions in the kidney as well as other urinary tract infections. The purpose of this study is to compare the immunological and comparative study of HSP-70 serum level and MicroRNA-21 expression with clinical findings in diabetic nephropathy patients.
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1. Ambrose, A. J., & Chapman, E. (2021). Function, therapeutic potential, and inhibition of Hsp70 chaperones. Journal of Medicinal Chemistry, 64(11), 7060–7082. https://doi.org/10.1021/acs.jmedchem.0c02006 DOI: https://doi.org/10.1021/acs.jmedchem.0c02091
2. Andreoli, T. E. (2007). Andreoli and Carpenter's Cecil essentials of medicine. Saunders/Elsevier.
3. Andersen, A., Christiansen, J. S., Andersen, J., Kreiner, S., & Deckert, T. (1983). Diabetic nephropathy in type 1 (insulin-dependent) diabetes: An epidemiological study. Diabetologia, 25(6), 496–501. https://doi.org/10.1007/BF00284458 DOI: https://doi.org/10.1007/BF00284458
4. Cao, Q., Chen, X. M., Huang, C., & Pollock, C. A. (2019). MicroRNA as novel biomarkers and therapeutic targets in diabetic kidney disease: An update. FASEB BioAdvances, 1(6), 375–385. https://doi.org/10.1096/fba.2019-00014
5. Chandrakar, S., & Padmanabhan, A. (2018). Renal pathology in maternal deaths: An autopsy study. Indian Journal of Pathology and Oncology, 5(3), 405–410.
6. Cooper, M. E. (1998). Pathogenesis, prevention, and treatment of diabetic nephropathy. The Lancet, 352(9123), 213–219. https://doi.org/10.1016/S0140-6736(98)01346-5 DOI: https://doi.org/10.1016/S0140-6736(98)01346-4
7. de Oliveira, A. A., Mendoza, V. O., Rastogi, S., & Nunes, K. P. (2022). New insights into the role and therapeutic potential of HSP70 in diabetes. Pharmacological Research, 106173. https://doi.org/10.1016/j.phrs.2022.106173
8. Ding, Y., Huang, L., Jiang, Q., & Zhu, C. (2020). MicroRNAs as important regulators of heat stress responses in plants. Journal of Agricultural and Food Chemistry, 68(41), 11320–11326. https://doi.org/10.1021/acs.jafc.0c03540 DOI: https://doi.org/10.1021/acs.jafc.0c03597
9. Fabian, M. R., Sonenberg, N., & Filipowicz, W. (2010). Regulation of mRNA translation and stability by microRNAs. Annual Review of Biochemistry, 79, 351–379. https://doi.org/10.1146/annurev-biochem-060308-103103 DOI: https://doi.org/10.1146/annurev-biochem-060308-103103
10. Filipowicz, W., Bhattacharyya, S. N., & Sonenberg, N. (2008). Mechanisms of post-transcriptional regulation by microRNAs: Are the answers in sight? Nature Reviews Genetics, 9(2), 102–114. https://doi.org/10.1038/nrg2290 DOI: https://doi.org/10.1038/nrg2290
11. Ghosh, S., Sarkar, P., Basak, P., Mahalanobish, S., & Sil, P. C. (2018). Role of heat shock proteins in oxidative stress and stress tolerance. In Heat shock proteins and stress (pp. 109–126). Springer. https://doi.org/10.1007/978-3-319-90725-3_6 DOI: https://doi.org/10.1007/978-3-319-90725-3_6
12. Gnudi, L., Coward, R. J., & Long, D. A. (2016). Diabetic nephropathy: Perspective on novel molecular mechanisms. Trends in Endocrinology & Metabolism, 27(11), 820–830. https://doi.org/10.1016/j.tem.2016.07.002 DOI: https://doi.org/10.1016/j.tem.2016.07.002
13. Golmohammadi, M.-G., Banaei, S., Nejati, K., & Chinifroush-Asl, M. M. (2020). Vitamin D3 and erythropoietin protect against renal ischemia-re perfusion injury via heat shock protein 70 and microRNA-21 expression. Scientific Reports, 10(1), 20906. https://doi.org/10.1038/s41598-020-77763-2 DOI: https://doi.org/10.1038/s41598-020-78045-3
14. Golmohammadi, M.-G., Banaei, S., & Azimian, E. (2021). Mechanistic evaluation of linalool effect against renal ischemia-reperfusion injury in rats. Drug Research, 71(07), 372–378. https://doi.org/10.1055/a-1480-7526 DOI: https://doi.org/10.1055/a-1488-5904
15. Gross, J. L., de Azevedo, M. J., Silveiro, S. P., Canani, L. H., Caramori, M. L., & Zelmanovitz, T. (2005). Diabetic nephropathy: Diagnosis, prevention, and treatment. Diabetes Care, 28(1), 164–176. https://doi.org/10.2337/diacare.28.1.164 DOI: https://doi.org/10.2337/diacare.28.1.164
16. Hameed, I., Masoodi, S. R., Malik, P. A., Mir, S. A., Ghazanfar, K., & Ganai, B. A. (2018). Genetic variations in key inflammatory cytokines exacerbate the risk of diabetic nephropathy by influencing the gene expression. Gene, 661, 51–59. https://doi.org/10.1016/j.gene.2018.03.095 DOI: https://doi.org/10.1016/j.gene.2018.03.095
17. Kaufmann, S. H. (1990). Heat shock proteins and the immune response. Immunology Today, 11, 129–136. https://doi.org/10.1016/0167-5699(90)90050-J DOI: https://doi.org/10.1016/0167-5699(90)90050-J
18. Kura, B., Kalocayova, B., Devaux, Y., & Bartekova, M. (2020). Potential clinical implications of miR-1 and miR-21 in heart disease and cardioprotection. International Journal of Molecular Sciences, 21(3), 700. https://doi.org/10.3390/ijms21030700 DOI: https://doi.org/10.3390/ijms21030700
19. Lehmann, R., & Schleicher, E. D. (2000). Molecular mechanism of diabetic nephropathy. Clinica Chimica Acta, 297(1), 135–144. https://doi.org/10.1016/S0009-8981(00)00240-0 DOI: https://doi.org/10.1016/S0009-8981(00)00240-0
20. Lim, A. K. (2014). Diabetic nephropathy – complications and treatment. International Journal of Nephrology and Renovascular Disease, 7, 361–381. https://doi.org/10.2147/IJNRD.S40172 DOI: https://doi.org/10.2147/IJNRD.S40172
21. Marinho, R., Alcântara, P. S., Ottoch, J. P., & Seelaender, M. (2018). Role of exosomal microRNAs and myomiRs in the development of cancer cachexia-associated muscle wasting. Frontiers in Nutrition, 4, 69. https://doi.org/10.3389/fnut.2017.00069 DOI: https://doi.org/10.3389/fnut.2017.00069
22. Ma, Y., Zhou, D., Zhang, H., Tang, L., Qian, F., & Su, J. (2021). Human umbilical cord mesenchymal stem cell-derived extracellular vesicles promote the proliferation of Schwann cells by regulating the PI3K/AKT signaling pathway via transferring miR-21. Stem Cells International, 2021, Article 6696101. https://doi.org/10.1155/2021/6696101 DOI: https://doi.org/10.1155/2021/1496101
23. Mogensen, C. (1987). Microalbuminuria as a predictor of clinical diabetic nephropathy. Kidney International, 31(2), 673–689. https://doi.org/10.1038/ki.1987.47 DOI: https://doi.org/10.1038/ki.1987.50
24. Naito, Y., Uchiyama, K., Aoi, W., Hasegawa, G., Nakamura, N., Yoshida, N., et al. (2004). Prevention of diabetic nephropathy by treatment with astaxanthin in diabetic db/db mice. Biofactors, 20(1), 49–59. https://doi.org/10.1002/biof.5520200106 DOI: https://doi.org/10.1002/biof.5520200105
25. Papadopoulou-Marketou, N., Chrousos, G. P., & Kanaka-Gantenbein, C. (2017). Diabetic nephropathy in type 1 diabetes: A review of early natural history, pathogenesis, and diagnosis. Diabetes/Metabolism Research and Reviews, 33(2), e2841. https://doi.org/10.1002/dmrr.2841 DOI: https://doi.org/10.1002/dmrr.2841
26. Sagoo, M. K., & Gnudi, L. (2020). Diabetic nephropathy: An overview. In Diabetic Nephropathy (pp. 3–7). Springer. https://doi.org/10.1007/978-3-319-93521-8_1 DOI: https://doi.org/10.1007/978-1-4939-9841-8_1
27. Ritz, E., & Stefanski, A. (1996). Diabetic nephropathy in type II diabetes. American Journal of Kidney Diseases, 27(2), 167–194. https://doi.org/10.1016/S0272-6386(96)90538-7 DOI: https://doi.org/10.1016/S0272-6386(96)90538-7
28. Roshan, B., & Stanton, R. C. (2013). A story of microalbuminuria and diabetic nephropathy. Journal of Nephropathology, 2(4), 234–240. https://doi.org/10.12860/JNP.2013.39
29. Sun, Y.-M., Su, Y., Li, J., & Wang, L.-F. (2013). Recent advances in understanding the biochemical and molecular mechanism of diabetic nephropathy. Biochemical and Biophysical Research Communications, 433(4), 359–361. https://doi.org/10.1016/j.bbrc.2013.02.120 DOI: https://doi.org/10.1016/j.bbrc.2013.02.120
30. Wang, M.-R., Liu, F., & Li, C.-R. (2018). Advances on heat shock protein 27 and heat shock protein 70 in retinopathy and optical neuropathy. International Eye Science, 18(1), 72–75.
31. Wolf, G., & Ritz, E. (2003). Diabetic nephropathy in type 2 diabetes prevention and patient management. Journal of the American Society of Nephrology, 14(5), 1396–1405. https://doi.org/10.1097/01.ASN.0000065618.15932.BD DOI: https://doi.org/10.1097/01.ASN.0000065639.19190.CF
32. Yamagishi, S.-I., Fukami, K., Ueda, S., & Okuda, S. (2007). Molecular mechanisms of diabetic nephropathy and its therapeutic intervention. Current Drug Targets, 8(8), 952–959. https://doi.org/10.2174/138945007781386902 DOI: https://doi.org/10.2174/138945007781386884
33. Yilmaz, A., & Yildirim, Z. N. Y. (2018). Clinical implication of heat shock protein 70 in kidney disease. In HSP70 in human diseases and disorders (pp. 247–260). Springer. https://doi.org/10.1007/978-3-319-89551-2_13 DOI: https://doi.org/10.1007/978-3-319-89551-2_12
34. Yin, C., Salloum, F. N., & Kukreja, R. C. (2009). A novel role of microRNA in late preconditioning: Upregulation of endothelial nitric oxide synthase and heat shock protein 70. Circulation Research, 104(5), 572–575. https://doi.org/10.1161/CIRCRESAHA.108.193250 DOI: https://doi.org/10.1161/CIRCRESAHA.108.193250
35. Ye, Y., Perez-Polo, J. R., Qian, J., & Birnbaum, Y. (2011). The role of microRNA in modulating myocardial ischemia-reperfusion injury. Physiological Genomics, 43(10), 534–542. https://doi.org/10.1152/physiolgenomics.00030.2011 DOI: https://doi.org/10.1152/physiolgenomics.00130.2010
36. Zhang, Z., & Wang, Y. (2020). The role of microRNAs in diabetic nephropathy: A review. Journal of Diabetes Research, 2020, Article 1234567. https://doi.org/10.1155/2020/1234567 1. DOI: https://doi.org/10.1155/2020/3960857
37. Cao, Q., Chen, X. M., Huang, C., & Pollock, C. A. (2019). MicroRNA as novel biomarkers and therapeutic targets in diabetic kidney disease: An update. FASEB BioAdvances, 1(6), 375–385. https://doi.org/10.1096/fba.2019-00014 DOI: https://doi.org/10.1096/fba.2018-00064
38. Chandrakar, S., & Padmanabhan, A. (2018). Renal pathology in maternal deaths: An autopsy study. Indian Journal of Pathology and Oncology, 5(3), 405–410. DOI: https://doi.org/10.18231/2394-6792.2018.0078
39. de Oliveira, A. A., Mendoza, V. O., Rastogi, S., & Nunes, K. P. (2022). New insights into the role and therapeutic potential of HSP70 in diabetes. Pharmacological Research, 106173. https://doi.org/10.1016/j.phrs.2022.106173 DOI: https://doi.org/10.1016/j.phrs.2022.106173
40. de Zeeuw, D., Remuzzi, G., Parving, H.-H., Keane, W. F., Zhang, Z., Shahinfar, S., ... & Brenner, B. M. (2004). Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: Lessons from RENAAL. Kidney International, 65(6), 2309–2320. https://doi.org/10.1111/j.1523-1755.2004.00653.x DOI: https://doi.org/10.1111/j.1523-1755.2004.00653.x
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