Influence of LGALS3 Gene Polymorphism as A Potential Predictor for Cardiopathy Complication of Type 2 Diabetes Mellitus

Abstract

Galectin-3(Gal-3) belongs to lectins family binding β-galactoside that have at least one of the carbohydrate recognition domains (CRDs) in their own structure, which located on chromosome 14 (14q22.3).Gal-3Plays an important role in modulating cardiac inflammation and fibrosis. Therefore, LGALS3 gene, encoding galectin-3 protein, which considered promising candidate for the genetic study of cardiovascular diseases (CVDs),and evaluating the association between LGALS3 gene polymorphisms and the susceptibility and prognosis of myocardial infarction(MI) .Gal-is a pleiotropic molecule expressed on the cell membrane, within the cytoplasm or the nucleus. It has been proposed to function as a mediator of inflammation, fibrosis, cell adhesion, apoptosis, and chemotaxis. It is highly expressed in macrophages within and atherosclerotic plaques.galectin-3 can mediate production of profibrotic factors and collagen accumulation in a variety of diseases. The role of galectIn-3 in regulating macrophage invasion and consequent modulation of atherosclerotic plaque phenotype. Finally, the current study concluded that the amount of LGALS-3 gene expression is related to rs4652 SNP variant in patients with MI due toT2D complications.