A Biochemical Study for Evaluation of Some Cellular Oxidation parameters in Sera Samples of Gastrointestinal Tumors

Abstract

     During the period from the beginning of December 2018 to the end of May 2019, 108 resident of Babylon were included to participate in the current study, were divided into two main groups: 81 patients with GIT diseases, their age ranged from 12-80 years; and the controls group (27 individuals) with the age 17-71 years old. Furthermore, the patient group was divided into two subgroups, the first involved 51patients with GIT tumors and the other with non-tumoral diseases of GIT (30 individuals suffered non tumoral GIT illness were enrolled as a pathological control group).

      Superoxide Dismutase (SOD), Nitric Oxide (NO), Oxidized Glutathione (GSSG), and Total Glutathione (T-GSH)) were evaluated in the sera samples of the study groups. The current study revealed statistical significant increase in the levels of SOD. Results of the present study illustrate that approximately 73% of malignant GIT tumors showed a statistically significant positive relationship (p < 0.05) when SOD and NO correlated together. On the other hand, a significant negative correlation (r = - 0.582 at p < 0.05, r = - 0.681 at p <0.05) when the levels of SOD with GSSG as well as T-GSH in the malignant GIT tumors patients were correlated, respectively. About 86% of patients with cancerous GIT tumors showed a negative correlation when the levels of NO and T-GSH were compared together (at p = 0.002).

     SOD showed the highest (94%) single sensitivity among the assessed criteria. Moreover, the study exposed SOD as the most specific (78%) individual bio detector. The specificity% reached to 94% and 89%when T-GSH combined to SOD and NO; respectively.