Genetic susceptibility associated with toxoplasmosis; genetic polymorphism, molecular and immunological study
DOI:
https://doi.org/10.36320/ajb/v8.i2.9275Keywords:
Toxoplasmosis, Toxoplasma gondii, IFN γ, TLR, TUB1Abstract
In the present study 258 blood samples were gathered from the gynecology wards in Babylon hospital for children and maternity and out private clinic from Babylon and Baghdad province during the period from September 2014 to January 2015 for investigation on toxoplasmosis infections and the study effect of genes modifications on infection susceptibility by parasite. this research was carried out in laboratory of genetic researches in College of Science for girls- Babylon university .
Expression of many cytokines like TNF-α and IL- 1β and genes like ALOX12 through infection with Toxoplasma gondii were revealed modifies as a result in this study. Genotypic and allelic frequency of IFN-γ +874 T/A were statistically differences in relation to the occurrence of the A allele in many cases of parasitic infection. Genetic frequency of sag4 gene among patients was higher than control 10.7% and 1.3%, respectively. The genetic profiling of TLRs revealed that TLR11 and TLR12 was 21.1% and 21.7%, respectively, also the genetic profiling of TUB1 and FOL1 revealed that TUB1 and FOL1 was 19.2% and 16.4% respectively, while IL-6 and IL-1β genes was 14.8%, 12.9% in that order.
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