Synthesis, characterization of a new series of thiohydantoin derivatives and study their biological activity against prostate cancer and microbes.

Abstract

Prostate cancer is one of the most common malignant diseases in men, and the design of new chemical compounds against prostate cancer is one of the challenges faced by modern medicine. In this study, we prepared and characterized a new series of thiohydantoin derivatives by reacting maleimide derivatives (1C-4) with cyclohexyl isothiocyanate.The prepared compounds were diagnosed using (FT-IR ,¹H-NMR ,¹³C-NMR ).MTT assay was used to determine the activity of the prepared compounds against prostate cancer cell lines, as the data indicated, based on IC50 values, that the prepared compounds do not have anti-prostate cancer activity. The prepared compounds were also studied against selected types of bacteria and fungi, as the data indicated that some of the prepared series compounds had anti-bacterial and anti-fungal activity under study, as the compound 4C showed a high anti-staph activity.