Preparation,Characterization And Biological Activity Of Some New Amides From Thiazolidine-4-carboxylic Acid.

Abstract

A new series of amides from different aromatic amines and2-phenyl thiazolidine-4-carboxylic acid which were prepared from the reaction of benzaldehyde with D-penicillamine under slightly conditions, thiazolidine have been synthesized in one step by cyclization of penicillamine with benzaldehydes in ethanol and water at room temperature . The amine group in the thiazolidine ring is protected by reaction with the acetic anhydride ,which was converted to the corresponding 3-aceylthiazolidine derivative . Reaction of N-aceyl-protected carboxylic acids with different amines using DDC/HOBt gave corresponding amides ,The general synthesis of 2-phenyl-thiazolidine-4-carboxylic acid amides is shown in Scheme 1. All products were characterized and identified by FT.I.R and ¹H-NMR spectroscopy , and Finally a biological activity (antimicrobial) for the new prepared products were checked.