Study the markers of follicle stimulating hormone and transforming growth factor β1 in patients with polycystic ovarian syndrome in AL-Najaf Al-Ashraf province

Authors

  • Farhan Abood Risan Al-Fartosi
  • Abbas Sahib Fakhar Al-Naffakh

DOI:

https://doi.org/10.36320/ajb/v11.i1.8040

Keywords:

PCOS, FSH, TGF-β1 , infertility

Abstract

Polycystic Ovary Syndrome (PCOS) is an endocrine disorder affecting 6-15% of women in age (12-45) years . It is characterized by disturbance in menstrual cycle ,androgenic features, and presence of multiple small cyst in ovaries in ultrasound. It is the important cause of infertility. The etiology of  the disease remains unclear and may be associated with insulin resistance, obesity  , type 2  diabetes mellitus, hyperandrogenism , environmental and familial genetic factors . PCOS has a role is the appearance of  hirsutism , acne  ,  hypertension and dyslipidemia with increase risk factor of cardiovascular disease (CVD).

Downloads

Download data is not yet available.

References

Klimczak, D.; Szlendak-Sauer, K .and Radowicki, S. (2015). Depression in relation to biochemical parameters and age in women with polycystic ovary syndrome. Eur. J. Obst. Gynecol. Reprod. Biol. 184:43-7.

.Stefanaki C, Bacopoulou F, Livadas S, Kandaraki A, Karachalios A, and Chrousos GP. (2015) .Impact of a mindfulness stress management program on stress, anxiety, depression and quality of life in women with polycystic ovary syndrome: a randomized controlled trial. Stress.18:57–66.

Fauser, B.; Tarlatzis, B.; Rebar, R.; Legro, R. ;Balen, A and Lobo , R (2012). Consensus on womens's health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM- Sponsored 3rd PCOS consensus workshop group. Fertil. Steril. 97(1):28-38.

Rotterdam ESHRE /ASRM.(2004).Sponsored PCOS consensus workshop group .Revised 2003 consensus on diagnostic criteria and long- term health risks related to polycystic ovary syndrome . Fertil. Steril. Hum. Reprod. 19:1:41-47.

Nath, C.K.; Barman, B.; Das, A.; Rajkhowa, P.; Baruah, P.; Baruah, M. and Baruah, A. (2019).Prolactin and thyroid stimulating hormone affecting the pattern of LH/FSH secretion in patients with polycystic ovary syndrome: A hospital-based study from North East India. J .Family. Med. Prim. Care. 8:256-60.

David, H.; Daniel, A.; and Jon, E. (2019).Hyperandrogenic origins of polycystic ovary syndrome – implications for pathophysiology and therapy. Expert Rev. of Endocrinol. and Metab.:1-44. DOI: 10.1080/17446651.2019.1576522.

Papalou, O. and Diamanti-Kandarakis, E.(2017). The role of stress in PCOS. Expert Rev. Endocrinol . Metab.12:87–95.

Maria, I.; Mora, M.; Rosa, C.; Angeles, M. and Hector, F. (2018). Gut microbiota and the polycystic ovary syndrome: Influence of sex ,sex hormones and obesity. The J. of Clin. Endocrinol. and Metab. 103( 7): 2552–2562.

Luque-Ramirez, M. and Escobar-Morreale, HF.(2014). Polycystic ovary syndrome as a paradigm for prehypertension, prediabetes, and preobesity. Curr. Hypertens . Rep .16(12):500.

Wild RA, Carmina E, Diamanti-Kandarakis E, Dokras A, Escobar-Morreale HF, Futterweit W, Lobo R, Norman RJ, Talbott E and Dumesic DA.(2010). Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the PCOS: a consensus statement by the Androgen Excess and PCOS (AE-PCOS) Society. J Clin Endocrinol Metab . 95(5):2038–2049.

Marlieke, A.; Jacobien, B.; Marlise, N.; Maria, P.; Annemieke, M. and Annemieke, M.(2018). Cardiovascular and metabolic health of 74 children from women previously diagnosed with polycystic ovary syndrome in comparison with a population-based reference cohort. Reprod. Sci . SAGE . J. 10. :1- 9.

Palomba S, de Wilde MA, Falbo A, Koster MP, La Sala GB and Fauser BC.(2015). Pregnancy complications in women with polycystic ovary syndrome. Hum Reprod Update. 21(5):575-592.

Victor, E. and Bruce, R. (2013). Hypothalamic-pituitary-ovarian axis and control of the menstrual cycle .Chapter 2 .Clin. Reprod. Med.and Surgery: A Practical Guide. 31- 42.

Catteau-Jonard .S, Soazik P., Arnaud Leclerc J., Jacques G., Dider D., and Nathalie D.C. (2008).Anti-Mullerian Hormone, Its Receptor FSH Receptor and Androgen Receptor Gene Are Overexpressed by Granulosa Cells form Stimulated Follicles in Women with Polycystic ovary Syndrome, J Clin Endocrinal Metab. 93:4456-4461.

Mohiyideen, L. and Nardo, L. (2010) Single-nucleotide polymorphism in the FSH receptor gene and ovarian performance: Future role in IVF, human Fertil. J. 13. :72-78.

Hashemi, A. Hossein ; Mozdarani, H. and Naghavi, A.(2016). Comparison of the Levels of LH and FSH, TSH, prolactin, progesterone and estradiol hormones between Iranian infertile women with polycystic ovary syndrome and healthy women. Int. J. of Med. Res. & Health Sci. 5 (12):370-375.

Ozgur O. and Kutluk O. (2009).Current Knowledge in Renewal Capability of Germ Cells in the Adult Ovary, Birth Defects Research (Part C): Embryo Today: Reviews Journal. 87:90-95.

Monga, A. and Dobb, S. (2006).The normal menstural cycle. In: Monga S, editor. Gynaecol. ed 18 : 32-42.

Besecke, L.; Guendner, M.; Schneyer, A.; Bauer-Dantoin, A.; Jameson, J. and Weiss, J.(1996). Gonadotropin-releasing hormone regulates follicle-stimulating hormone-beta gene expression through an activin/follistatin autocrine or paracrine loop. Endocrinol. 137(9):3667–73.

Xin-Yue, Z.; Hsun-Ming, C.; Hua, Z.; Rui-Zhi, L. and Peter, K.(2019). Leung.BMP6 increases TGF-beta1 production by up-regulating furin expression in human granulosa-lutein cells. Elsevier Editorial System(tm) for EBio Med . : 1-31 .

Li, H.; Chang, M.; Shi, Z. and Leung, K.(2018). Snail Mediates TGF-β1-induced downregulation of 456 Pentraxin 3 expression in human granulosa cells. Endocrinol .159(4): 1644-1657 .

Stepien-Wyrobiec, O.; Hrycek, A. and Wyrobiec, G.(2008). Transforming growth factor beta (TGF-beta): Its structure, function, and role in the pathogenesis of systemic lupus erythematosus. Post Hig. Med. Dosw. 62:688–93.

Celliere G, FengosG, Herve´ M and Iber D(2011). Plasticity of TGF-bsignaling. BMC Syst Biol. 5:184.

Alexandra, S.; Patricia, R. and David, F.(2018). Albertini . GDF-9 and BMP-15 direct the follicle symphony. J. of Ass. Reprod. and Genetics.Springer Sci. :1-10.

Welt, CK.; Taylor, AE.; Fox, J.; Messerlian, GM.; Adams, JM.; and Schneyer AL. (2005) Follicular arrest in polycystic ovary syndrome is associated with deficient inhibin A and B biosynthesis. J Clin Endocrinol Metab. 90(10):5582-5587.

Aihara, I.; Yagi, S.; Akaike, M. and Matsumoto, T.(2011). Transforming growth factor-β1 as a common target molecule for development of cardio vascular diseases, renal insufficiency, and metabolic syndrome. Cardiol. Res. and Practice.10 (40) : 1-9.

Gonzalez, F.; Rote, NS.; Minium, J. and Kirwan, J.(2006). Increased activation of nuclear factor kB triggers inflammation and insulin resistance in polycystic ovary syndrome. J. of Clin. Endocrinol. Metab. 91. :1508–1512.

Gonzalez, F.; Rote, S.; Minium, J. and Kirwan, J.(2009). Evidence of proatherogenic inflammation in polycystic ovary syndrome.Metab. 58:954–962.

Raja-Khan, N.; Kunselman, R.; Demers, M.; Ewens, G.; Spielman, S. and Legro, S.(2010). Avariant in the fibrillin-3 gene is associated with TGF-beta and inhibin B levels in women with polycystic ovary syndrome .Fertil. Steril. 94:2916–9.

Roh, E.; Yoon, H.; Song, Y.; Kim, J.; Hwang, R.; Seo, H. and Shin, S.(2016). Single nucleotide polymorphisms in the TGF-beta1 gene are 458 associated with polycystic ovary syndrome susceptibility and characteristics: a study in Korean 459 women. 2017.J. Assist. Reprod. Genet. 34(1): 139-147.

Hsun-Ming, C.; Yi-Min., Z. and Peter, L.(2019).Role of TGF-β superfamily members .The Ovary (Third Edition). Chapter 7 - Cell-Cell Interactions in Ovarian Follicles. : 107-125.

Belli, M. and Shimasaki, S.(2018). Molecular aspects and clinical relevance of GDF9 and BMP15 in ovarian function. Vitam. Horm. 107:317-348.

aja-Khan Nazia, Margrit Urbanek, Raymond J. Rodgers, and Richard S. Legro(2014).The Role of TGF-b in Polycystic Ovary Syndrome. 2014. Reprod Sci. 21(1): 20–31.

Shalal, MM.; Jasim, SK. and Shareef, RM. (2017). The Polycystic Ovary Syndrome as A cause of increase in inflammatory markers and metabolic risks. Iraqi Academic. Sci. J. 16(4) :331- 340.

Haldun, A.(2019 ).Major determinants of circulating myostatin in polycystic ovary syndrome. Experimental and therapeutic medicine .17: 1383-1389.

Gowri, V.; Rizvi, G. and Saquib, S.(2013).Relationship of high sensitivity C-reactive protein and other biochemical parameters of metabolic syndrome in women with polycystic ovarian syndrome and BMI matched controls. Res. In Endocrinol : 1-6.

Shakir,EW.; Wafeq,SA. and Al Hussen, NA.(2014). Studying the Effect of LeutiniZing Hormone and Follicular Stimulating Hormone on Poly Cystic Ovary Syndrome in Married and in Non-married Women. A.J.P.S. 14(1) :79-84.

Aljelawy, ZH. And Al-Sallami, AS. (2019). Role of Kisspeptin Polycystic Ovary disease in patients of AL Najaf AL Ashrif City , Iraq. J. of Pharm. Sci. and Res . l 11(1) :169 – 173.

Ramadhan,RS.; Ali, RJ. and AL-gafari, RJ (2017) .Physiological and molecular Study on polycystic ovary syndrome in a sample of Iraqi women”. Int. J. of Current Res. 8(12):42701-42711.

Dennis L. Kasper and Eugene Braunwald (2004).In Harrison principles of internal medicine .16th ed .New York Mc Graw Hill Professional.Vol. 2.

Abdulameer, LN.; AL-Rekabi, NG.; Almashat, RM.and Al-Obaidy, FK. (2016). Hormonal Study of the different phenotypes of polycystic ovary Syndrome . J. of the Faculty of Basic Education. 22 (93) :101 – 108.

Mahdi, QA.; Adbul Rahman, SA and Mohammed, FM. (2016) Measurement of ferritin and transforming growth factor-β1 levels in Iraqi women with polycystic ovary syndrome . Ibn Al-Haitham J. for Pure & Appl. Sci. 29(2)p: 171 -184.

Rashad, NM.; Amin, AI.; Ayman E.Ali, AE. and Soliman, MH. (2018) .Influence of obesity on soluble endoglin and transforming growth factor β1 in women with polycystic ovary syndrome. Middle East Fertil. Society J. 23(4):418–424.

al, R.; Seifer, DB.; Shohat-Tal, A.; Grazi, RV. and Malter, HE. (2013).Transforming growth factor-b1 and its receptor soluble endoglin are altered in polycystic ovary syndrome during controlled ovarian stimulation. Fertil Steril. 100(2):538-543.

Yu-Ching, C.; Hsun-Ming, C.; Jung-Chien, C.; Horng-Der, T.; Cheng-Hsuan, W. and Peter, C.(2015).Transforming growth factor-b1 up-regulates connexin43 expression in human granulosa cells. Human Reprod .30(9) :2190–2201.

Chegini, N.(2008).TGF-beta system: the principal profibrotic mediator of peritoneal adhesion formation. Semin Reprod. Med .26:298–312.

Govinden, R. and Bhoola, KD.(2003). Genealogy, expression, and cellular function of transforming growth factor-beta. Pharmacol and Therapeutics. 98(2):257-65. 48.Knight, PG. and Glister, C.(2003). Local roles of TGF-beta superfamily members in the control of ovarian follicle development. Anim Reprod Sci. 78(3-4):165–83.

Knight, PG. and Glister, C.(2006).TGF-beta superfamily members and ovarian follicle development. Reprod.132(2):191–206.

Wang, Z-P.; Mu, X-Y.; Guo, M.; Wang, Y-J.; Teng, Z.; Mao, G-P. and Niu, W-B. (2014).Transforming growth factor-β signaling participates in the maintenance of the primordial follicle pool in the mouse ovary. J. Biol .Chem. 289(12):8299–311.

Li, Q.; Agno, JE.; Edson, MA.; Nagaraja, AK.; Nagashima, T. and Matzuk, MM.(2011).Transforming Growth Factor β Receptor Type 1 Is Essential for Female Reproductive Tract Integrity and Function. PLoS Genet. 7(10):e1002320; DOI:10.1371/journal.pgen.1002320.

Romano, M.; Guagnano, MT.; Pacini, G.; Vigneri, S.; Falco, A.; Marinopiccoli, M.; Manigrasso, MR,; Basili, S, and Davi, G.(2003) Association of inflammation markers with impaired insulin sensitivity and coagulative activation in obese healthy women. J. Clin. Endocrinol. Metab. 88: 5321–5326.

Aihara, K.; Ikeda, Y.; Yagi, S.; Akaike, M. and Matsumoto, T.(2011). Transforming growth factor-β1 as a common target molecule for development of cardiovascular diseases, renal insufficiency, and metabolic syndrome. Cardiology Res. and Practice. 10: 1-9.

Coucke, PJ.; Willaert, A.; Wessels, MW.; Callewaert, B.; Zoppi, N.; De Backer, J.; Fox, JE .; Mancini, GM.; Kambouris, M.; Gardella, R.; Facchetti, F.; Willems, PJ.; Forsyth, R.; Dietz, HC.; Barlati, S.; Colombi, M.; Loeys, B. and De Paepe, A.(2006).Mutations in the facilitative glucose transporter GLUT10 alter angiogenesis and cause arterial tortuosity syndrome. Nat Genet. 38(4):452-457.

Gonzalez, F.; Minium, J.; Rote, NS. and Kirwan, JP.(2005) Hyperglycemia alters tumor necrosis factor-a release from mononuclear cells in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 90:5336–5342.

Gonzalez, F.; Nair, KS.; Daniels, JK.; Basal ,E. and Schimke, JM. (2012).Hyperandrogenism sensitizes mononuclear cells to promote glucose-induced inflammation in lean reproductive-age women. American. J. Physiol. Endocrinol. Metab. 302(3): 297-306.

Downloads

Published

2019-07-10

How to Cite

Abood Risan Al-Fartosi, F., & Sahib Fakhar Al-Naffakh, A. (2019). Study the markers of follicle stimulating hormone and transforming growth factor β1 in patients with polycystic ovarian syndrome in AL-Najaf Al-Ashraf province. Al-Kufa University Journal for Biology, 11(1), 94–106. https://doi.org/10.36320/ajb/v11.i1.8040

Similar Articles

1 2 3 4 > >> 

You may also start an advanced similarity search for this article.