Hepatoprotective Effect of Matricaria chamomilla Hot Aqueous Extract Against Methomyl 90%- Induced Hepatotoxicity In Mice
DOI:
https://doi.org/10.36320/ajb/v8.i2.9271Keywords:
methomyl insecticide, chamomile,liver,toxicity,remediation , mice.Abstract
The effect of orally feeding of hot liquid extract of (Matricaria chamomilla flowers) on hepatotoxicity induced to male mice by methomyl ,S-methyl-1-N-[(methylcarbamoyl)oxy]thioacetimidate (IUPAC) was investigated for( 30 days). These effects could be explored by measuring any changings in the weight of both body and liver.Histopathological examination of liver has been performed also along with aspartate aminotransferase(ALAT) and alanine aminotransferase (ASAT) levels in serum.
The results showed that the poisoned group treated with pesticide by using two doses of hot aqueous extract of chamomile (5 and 7) mg / kg of body weight have shown a marked improvement of the symptoms of pesticide poisoning, compared with the positive control group of the pesticide and that the dose of the methomyl 90% led to the toxic effects appeared by decreasing in body weights in mice and noticeable changes in liver tissue accompanied by increasing in its weight.There was significant increasing in the level of liver enzymes (ASAT, ALAT), Histopathological examination of liver sections of mice administered Matricaria chamomilla hot aqueous extract demonstrated reduction of damaged liver tissue induced by methomyl 90%.Current study reveals that hot aqueous extract of Matricaria chamomilla promises protection for hepatocytes against methomyl 90%- hepatotoxic mice induction. Finally,this study recommends that intake of hot aqueous extract of Matricaria chamomilla could be useful for liver disorders.
Downloads
References
- Raseir, G., Toppari, J., Parent, A. and Bourguignor, J. (2006) Female sexual maturation and reproduction after prepubertal exposure to estrogens and endocrine disrupting chemicals: A review of rodent and human data, Mol. Cell Endocrinol., vol. 254: 187–201. DOI: https://doi.org/10.1016/j.mce.2006.04.002
- Haddad LM& Winchester JF (1983) Clinical management of poisoning and drug overdose. WB Saunders &Co., Philadelphia, London, Toronto: 364-373.
- Abd Rabou A & Al-Agha M (1998) Environmental awareness in handling and application of pesticides among farmers in Rafah governorate-Gaza Strip. The Vth International HCH and Pesticide Forum, Bilbao, Spain. June, 25-27, 1998.
- Baron R. L. (1991) Carbamate insecticides, In Handbook of Pesticide Toxicology – Vol 3, Hayes WJ., Laws E.R. (Eds).San Diego, Calif, Academic Press, New York.pp 1125-90.
- EPA. (1996) Drinking Water Regulations and Health Advisories,USEPA, 822-B-96-002, Washington, DC
- Agha A., Dib S., Al-Hakami M., Abdulhadi Ali M. (2009) The IntrnetJrnl of Toxicol, 7:1.
-Singh, O., Khanam, Z., Misra, N. and Srivastava, M. (2011) Chamomile (matricaria chamomilla l.): An overview, Phcog. Rev., vol. 5: 82-95. DOI: https://doi.org/10.4103/0973-7847.79103
- Wang, Y., Tang, H., Nicholson, J., Hylands, P., Sampson, J. and Holmes, E. (2005) Metabonic strategy for the detection of the metabolic effects of Chamomile( matricaria recutita l.) ingestion, J. Agricultural and Food Chem., vol. 53: 191-196. DOI: https://doi.org/10.1021/jf0403282
- Gruenwald, J.; Brendler, T. and Jaenick, C. (1998). PDRfor herbal medicine .1stEd. economics company, Inc pp: 981-982.
- Newall, C.A.; Anderso, A. and Phillipson, J.D.(1996.Herbal medicine: A guide for Health care professionals. The pharmaceutical press. London pp: 49-70.
- Schiller, N.K. and McNamara, D.B. (1999). Balloon catheter vascular injury of the alloxan- induced diabetic rabbit: The role of insulin-like growth factor-1. Molecular and Cellular Biochemistry, 202:159-167. DOI: https://doi.org/10.1023/A:1007005919319
-Tietz, N. W. (2006) Textbook of clinical chemistry and molecular diagnostics, Edited by: C.A. Burtis, E.R. Ashwood and D.E. Bruns, CA: Elsevier Saunders.
-Gupta, A. and Misra, N. (2006) Hepatoprotective activity of aqueous ethanolic extract of Matricaria chamomilla in paracetamol intoxicated albino rats, American Journal of Pharmacology and Toxicology, vol. 1: 17-20 DOI: https://doi.org/10.3844/ajptsp.2006.17.20
-Bradberry, S. M., Proudfoot, A. T. and Vale, J. A. (2004) Poisoning due to chlorophenoxy herbicides, Toxicol. Rev., vol. 23: 65-73. DOI: https://doi.org/10.2165/00139709-200423020-00001
-Occupational Health Services, Inc. 1986. Material safety data sheet .Secaucus,NJ: OHS.Inc.
-Undeger, U., Institoris, L., Siroki, O., Nehez, M. and Desi, I. (2000) Simultaneous geno- and immunotoxicological investigations for early detection of organophosphate toxicity in rats, Ecotoxicol. Environ. Safe., vol. 45: 43–48. DOI: https://doi.org/10.1006/eesa.1999.1844
-Amacher, D., Schomaker, S. and Burkhardart, J. (1998) The relationship among microsomal enzyme induction, liver weight and histological change in rat toxicology studies, Food Chem. Toxicol., vol. 36: 831–839 DOI: https://doi.org/10.1016/S0278-6915(98)00066-0
- Troudi, A., Amara, I., Samet, A. and Zeghal, N. (2012) Oxidative stress induced by 2, 4-phenoxyacetic acid in liver of female rats and their progeny:Biochemical and histopathological studies, Environmental Toxicology, vol. 27: 137-145. DOI: https://doi.org/10.1002/tox.20624
- Purcell,G.V.; Behenna, D.B.; Walsh, P.R.; Alanine aminotransferase and aspartate aminotransferase measurements with two automated analyzers, SMAC and the ABA-100, Compared. Clin.Chem. 1979, 25, 780-782. DOI: https://doi.org/10.1093/clinchem/25.5.780
- Guilhermino L, Soares AMVM, Caenalho AP& Lopes MC (1998) Effects of cadmium and parathion exposure on hematology and blood biochemistry of adult male rats. Bulletin of Environmental Contamination &Toxicology 60: 52-59 DOI: https://doi.org/10.1007/s001289900590
-Ashour A (1999) Comparative study on the effect of some insecticides administration on protein content and some enzymes of rabbit's serum. Annual Review for Arts, Science & Education, Faculty of Women, Ain Shams University: Science section 20: 72-87
-Rigon AR, Reis M &Takahashi RN (1994) Effects of carbaryl on some dopaminergic behaviours in rats.General Pharmacology 25(6): 1263-1267 DOI: https://doi.org/10.1016/0306-3623(94)90148-1
-Kutlu S, Colakoglu N, Halifeoglu I, Sanadal S, Seyran AD, Aydin M & Yilmaz B (2005) Comparative evaluation of hepatotoxic and nephrotoxic effect of aroclors 1221 and 1254 in female rats. Cell Biochemistry & Function 25(2): 167-172 DOI: https://doi.org/10.1002/cbf.1289
- Dewan A, Bhatnager VK, Mathur M, Chakama T, Kashyap R, Sadhu HG, Sinha SK& Saiyed HN (2004) Repeated episodes of endosulphan poisoning. ClinicalToxicology 42(4): 363-369 DOI: https://doi.org/10.1081/CLT-120039542
- Funakoshi T, Ohta O, Shimada H& Kojima S (1995) Effects of dithiocarbamates and cadmium on enzymatic activities in liver, kidney and blood of mice. Toxicology Letters 78: 183-188 DOI: https://doi.org/10.1016/0378-4274(95)03253-H
- Friedman LS, Brautbar N, Barach P, Wolfe A& Richter ED (2003)Creatine phosphate kinase elevations signaling muscle damage following exposures to anticholin esterases: 2 sentinel patients. Archives of Environmental Health 58(3): 167-71 DOI: https://doi.org/10.3200/AEOH.58.3.167-171
-Yoon J.Y., Oh S.H., Yoo S.M., Lee S.J., Lee H.S., Choi S.J., Moon C.K., Lee B.H. (2001) Toxicolog, 169: 153-161 DOI: https://doi.org/10.1016/S0300-483X(01)00502-9
- Raffray M., Cohen G.M. (1997) PharmacolTher, 75: 153-177. DOI: https://doi.org/10.1016/S0163-7258(97)00037-5
-Wyllie A.H. (1980) Nature, 284: 555-556. DOI: https://doi.org/10.1038/284555a0
-Quest J.A., Chan P.C., Crawford D., Kanagalingam K.K., Hall W.C. (1987) Fundam Appl Toxicol, 8(3): 389-99. DOI: https://doi.org/10.1093/toxsci/8.3.389
-Landon E.J., Naukam R.J., Rama Sastry B.V. (1986) Biochem Pharmacol, 35: 697-705. DOI: https://doi.org/10.1016/0006-2952(86)90369-2
-Diez-fernandez C., Bosca L., Fernandezsimon L., Alvarez A., Cascales M. (1993) Hepatology, 18: 912-918. DOI: https://doi.org/10.1002/hep.1840180424
-McCarrol N.E., Protzel A., Ioannou Y., Frank Stack H.F., Jackson M.A., Waters M.D., Dearfield K.L. (2002) Mutat Res, 512(1): 1-35.
-Ksheerasagar R.L., Kaliwal B.B. (2006) Caspian J Env Sci, 4(1): 61-70.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2017 Jenan Mahdi Chani, Noor Zuhair Jasim
This work is licensed under a Creative Commons Attribution 4.0 International License.
which allows users to copy, create extracts, abstracts, and new works from the Article, alter and revise the Article, and make commercial use of the Article (including reuse and/or resale of the Article by commercial entities), provided the user gives appropriate credit (with a link to the formal publication through the relevant DOI), provides a link to the license, indicates if changes were made and the licensor is not represented as endorsing the use made of the work.
