Synthesis and characterization of new 1,3-thiazinane derivatives and study their effect on breast cancer (MCF-7)
Keywords:
Chalcone, thiazinane derivatives, breast cancer, MCF-7Abstract
The research includes synthesized some thiazinane (hexahydrothiazine) derivatives were synthesized from the reaction of chalcons with thiourea. FT-IR, Mass, and H1-NMR spectra identified the compounds. The new thiazinane derivatives (SH, Sm-NH2, Sp-NH2, Sp-NO2) applied on breast cancer (MCF-7) gave a different results. The inhibition ratio of prepared compounds according to the type of the substituted group where the thiazinane derivative with an amino group on meta position (Sm-NH2) was (75%). The thiazinane derivative without a substituted group (S.H.) was (47% ), then with an amino group on para position (Sp-NH2) was (26%), and with a nitro group on para position (Sp-NO2) was (5%).
Downloads
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Journal of Kufa for Chemical Sciences
This work is licensed under a Creative Commons Attribution 4.0 International License.
Open-access Statement
The journal « Journal Of Kufa For Chemical Sciences» provides immediate open access to its content on the principle that making research freely available to the public supports a greater global exchange of knowledge. Full-text access to scientific articles of the journal is presented on the official website in the Archives section.
This is in accordance with the BOAI definition of open access. The licensing policy is compatible with the overwhelming majority of open access and archiving policies.
The journal «Journal Of Kufa For Chemical Sciences» is an open access journal, which means all its content is freely available without charge to the user or his/her institution. Users are allowed to read, download, copy, distribute, print, search, or link to the full texts of the articles, or use them for any other lawful purpose, without asking prior permission from the publisher or the author as long as they cite the source.The journal is licensed by Creative Commons Attribution International( CC Attribution 4.0) .